Results 21 to 30 of about 2,293,083 (280)
The IL-1 Family and Its Role in Atherosclerosis. [PDF]
Int J Mol Sci, 2022 The IL-1 superfamily of cytokines is a central regulator of immunity and inflammation. The family is composed of 11 cytokines (with agonist, antagonist, and anti-inflammatory properties) and 10 receptors, all tightly regulated through decoy receptor, receptor antagonists, and signaling inhibitors.
González L +3 more
europepmc +3 more sources
IL-1 family nomenclature. [PDF]
Nat Immunol, 2010 To the Editor: Newly cloned interleukin 1 (IL-1) family members1–3 were originally given an IL-1 family (IL-1F) designation4, but as functions have now been elucidated for several of these5,6, we propose that each now be assigned an individual interleukin designation.
Dinarello C +32 more
europepmc +11 more sources
Frontiers in Immunology, 2022 Inflammation driven by environmental allergens is an important source of morbidity in diseases such as asthma and eczema. How common allergens promote inflammation is still poorly understood, but previous studies have implicated the protease activity ...
Valentina Frezza +4 more
doaj +1 more source
mAbs, 2023 Immune checkpoint inhibitors that overcome T cell suppressive mechanisms in tumors have revolutionized the treatment of cancer but are only efficacious in a small subset of patients.
John P. Dowling +14 more
doaj +1 more source
The Role of IL-36 in Infectious Diseases: Potential Target for COVID-19?
Frontiers in Immunology, 2021 IL-36 is a member of the interleukin 1 cytokine family, which is currently experiencing a renaissance due to the growing understanding of its context-dependent roles and advances in our understanding of the inflammatory response.
Xiaofang Wang +4 more
doaj +1 more source
IL-1 family cytokines in inflammation and immunity. [PDF]
Cell Mol ImmunolAbstract Interleukin-1 (IL-1) was the first interleukin identified as a potent proinflammatory and multifunctional molecule involved in innate immune responses against microbes, as well as in conditions of tissue injury associated with infections and sterile conditions.
Garlanda C, Di Ceglie I, Jaillon S.
europepmc +2 more sources
eLife, 2021 IL-33 is an alarmin required for resistance to the parasite Toxoplasma gondii, but its role in innate resistance to this organism is unclear. Infection with T. gondii promotes increased stromal cell expression of IL-33, and levels of parasite replication
Joseph T Clark +9 more
doaj +1 more source
MicroRNA-29 family expression and its relation to antiviral immune response and viro-immunological markers in HIV-1-infected patients [PDF]
, 2015 BACKGROUND: Several in vitro studies suggested the microRNA-29 (miRNA-29) family is involved in regulating HIV-1 and modulating the expression of interleukin (IL)-32, an anti-HIV-1 cytokine.
ANTONELLI, Guido +9 more
core +2 more sources
Nlrp6 promotes recovery after peripheral nerve injury independently of inflammasomes [PDF]
, 2015 Background: NOD-like receptors (Nlrs) are key regulators of immune responses during infection and autoimmunity. A subset of Nlrs assembles inflammasomes, molecular platforms that are activated in response to endogenous danger and microbial ligands and ...
De Winter, Vicky +6 more
core +2 more sources
Interleukin-37: associations of plasma levels and genetic variants in gout
Arthritis Research & Therapy, 2023 Objectives IL-37 is an anti-inflammatory cytokine involved in inflammatory and autoimmune diseases. We aimed to investigate the association between IL-37 genetic variants, IL-37 plasma levels, and various clinical phases of gout.
Lucie Andres Cerezo +7 more
doaj +1 more source