A key role for leukemia inhibitory factor in C26 cancer cachexia [PDF]
, 2015 Cachexia is an exacerbating event in many types of cancer that is strongly associated with a poor prognosis. We have identified cytokine, signaling, and transcription factors that are required for cachexia in the mouse C26 colon carcinoma model of cancer.
Jackman, Robert W. +2 more
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Insulin-like growth factors and related proteins in plasma and cerebrospinal fluids of HIV-positive individuals. [PDF]
, 2015 BackgroundClinically significant dysregulation of the insulin-like growth factor (IGF) family proteins occurs in HIV-infected individuals, but the details including whether the deficiencies in IGFs contribute to CNS dysfunction are unknown.MethodsWe ...
Choi, Namjong +4 more
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Interleukin-33 contributes to both M1 and M2 chemokine marker expression in human macrophages [PDF]
, 2010 Background Interleukin-33 is a member of the IL-1 cytokine family whose functions are mediated and modulated by the ST2 receptor. IL-33-ST2 expression and interactions have been explored in mouse macrophages but little is known about the effect of IL-33 ...
Das, Anuk +7 more
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Identification of small‐molecule elastase inhibitors as antagonists of IL‐36 cytokine activation
FEBS Open Bio, 2018 IL‐1 family cytokines act as apical initiators of inflammation in many settings and can promote the production of a battery of inflammatory cytokines, chemokines and other inflammatory mediators in diverse cell types.
Graeme P. Sullivan +9 more
doaj +1 more source
Enrichment of innate lymphoid cell populations in gingival tissue [PDF]
, 2018 Innate lymphoid cells (ILCs) are a population of lymphocytes that act as the first line of immunologic defense at mucosal surfaces. The ILC family in the skin, lungs, and gastrointestinal tissues has been investigated, and there are reports of individual
Adrados Planell, A. +5 more
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Guanine nucleotide exchange factor αPIX leads to activation of the Rac 1 GTPase/glycogen phosphorylase pathway in interleukin (IL)-2-stimulated T cells [PDF]
, 2015 Recently, we have reported that the active form of Rac 1 GTPase binds to the glycogen phosphorylase muscle isoform (PYGM) and modulates its enzymatic activity leading to T cell proliferation.
Gálvez, Patricia +6 more
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IL-1 Family Members in Health and Disease
, 2019 PUBLISHED In 1985, two distinct cDNAs encoding proteins sharing human Interleukin-1 (IL-1) activity were described, thus defining the first two members of the IL-1 family – IL-1α and IL-1β. These potent pro-inflammatory cytokines have been the subject of much research in the areas of fever, inflammation as well as their role in a myriad of inflammatory-
Doyle, Sarah L. +2 more
openaire +5 more sources
The Correlation between Inflammatory Biomarkers andLung Function in COPD Stable Phase
Guoji laonian yixue zazhiObjective To investigate the correlation between interleukin(IL) -1 family, classical inflammatory markers and pulmonary function in patients with stable chronic obstructive pulmonary disease(COPD).
Yuan Yuan +5 more
doaj +1 more source
Role of Interleukin-1 family in bone metastasis of prostate cancer
Frontiers in Oncology, 2022 Prostate cancer (PCa) is one of the most fatal diseases in male patients with high bone metastatic potential. Bone metastasis severely shortens overall survival and brings skeletal-related events (SREs) which reduces the life quality of patients, and ...
Yuanhao Tong +5 more
doaj +1 more source
Le rôle du thérapeute familial dans la construction du système thérapeutique [PDF]
, 1983 À l'aide de son expérience clinique, l'auteur essaie, dans cet article, d'illustrer comment le thérapeute familial construit un système thérapeutique.
Cosqueric, Jean-Pierre
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