Results 51 to 60 of about 2,293,083 (280)

The expression analysis of Fra-1 gene and IL-11 protein in Iranian patients with ulcerative colitis [PDF]

, 2018
Background: Fra-1 (fosl1) belongs to the activator protein1 (AP-1) family inducing IL-11 expression in oxidative stress condition. IL-11 plays a pivotal role in protecting epithelial barriers integrity.
Bagheri, Nader., Deris, Fatemeh., Ghatreh samani, Mahdi., Rahimian, Ghorbanali., Razmara, Ehsan., Sabzevary-Ghahfarokhi, Milad., shirzad, Hedayatollah., Shohan, Mojtaba., Soltani, Amin.   +8 more
core   +1 more source

IL-1 family cytokines in chronic inflammatory disorders [PDF]

Vnitřní lékařství, 2019
IL-1 family represent a group of structurally related cytokines with prevailing pro-inflammatory (IL-1α, IL-1β, IL-18, IL-33, IL-36α, IL-36β a IL-37γ) or anti-inflammatory (IL-1Ra, IL-36Ra, IL-38, IL-37) effects. They are involved not only in defense mechanisms and physiological modulation of homeostatic processes, but also in ...
openaire   +2 more sources

Critical Contribution of Nuclear Factor Erythroid 2-related Factor 2 (NRF2) to Electrophile-induced Interleukin-11 Production [PDF]

, 2017
Nuclear factor erythroid 2-related factor 2 (NRF2) is a transcription factor that plays a crucial role in protection of cells from electrophile-induced toxicity through up-regulating phase II detoxifying enzymes and phase III transporters.
Deguchi Yutaka, Kojima Yuko, Kumagai Yoshito, Miura Ryosuke, Nakano Hiroyasu, Nishina Takashi, Okumura Ko, Shinkai Yasuhiro, Yamazaki Soh, 新開 泰弘, 熊谷 嘉人   +10 more
core   +2 more sources

Il-1 family and its related diseases

Abant Medical Journal, 2019
İnterlökin-1 aile IL-1F üyeleri akut ve kronik inflamasyon ile ilişkilidir ve immün cevapta esaslı bir rol oynar. IL-1 aile üyelerinin biyolojik özellikleri tipik olarak pro-inflamatuardır. IL-1 ailesi 11 üyeye sahiptir ve onların prekürsörlerinin uzunluğuna göre alt ailelere sınıflandırılabilinir.
YİŞ, Özgür Mehmet, BUĞDAYCI, Güler
openaire   +2 more sources

A Quality Improvement Initiative to Standardize Pneumocystis jirovecii Pneumonia Prophylaxis in Pediatric Patients With Solid Tumors

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Pediatric patients with extracranial solid tumors (ST) receiving chemotherapy are at an increased risk for Pneumocystis jirovecii pneumonia (PJP). However, evidence guiding prophylaxis practices in this population is limited. A PJP‐related fatality at our institution highlighted inconsistent prescribing approaches and concerns about
Kriti Kumar, Denise M. Connolly, Ellen Kellington, Elyse Zelunka, Karla Kerrigan, Furqan Shaikh, Paul C. Nathan, Meredith S. Irwin, Sarah Cohen‐Gogo   +8 more
wiley   +1 more source

Autism with intellectual disability is associated with increased levels of maternal cytokines and chemokines during gestation. [PDF]

, 2016
Immune abnormalities have been described in some individuals with autism spectrum disorders (ASDs) as well as their family members. However, few studies have directly investigated the role of prenatal cytokine and chemokine profiles on neurodevelopmental
Ashwood, P, Croen, LA, DeLorenze, GN, Hansen, R, Heuer, L, Jones, KL, Kharrazi, M, Van de Water, J, Yolken, R, Yoshida, CK, Zerbo, O   +10 more
core   +2 more sources

Limited Contribution of IL-36 versus IL-1 and TNF Pathways in Host Response to Mycobacterial Infection [PDF]

, 2015
IL-36 cytokines are members of the IL-1 family of cytokines that stimulate dendritic cells and T cells leading to enhanced T helper 1 responses in vitro and in vivo ; however, their role in host defense has not been fully addressed thus far.
Segueni, Noria, Vigne, Solenne, Palmer, Gaby, Bourigault, Marie-Laure, Olleros, Maria L., Vesin, Dominique, Garcia, Irene, Ryffel, Bernhard, Quesniaux, Valérie F. J., Gabay, Cem   +9 more
core   +1 more source

Sickle Cell Disease Is an Inherent Risk for Asthma in a Sibling Comparison Study

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Introduction Sickle cell disease (SCD) and asthma share a complex relationship. Although estimates vary, asthma prevalence in children with SCD is believed to be comparable to or higher than the general population. Determining whether SCD confers an increased risk for asthma remains challenging due to overlapping symptoms and the ...
Suhei C. Zuleta De Bernardis, Okeleji Olayinka, Mariam Z. Quraishi, Lakshmi V. Srivaths, Deborah L. Brown, Neethu M. Menon, Ricardo A. Mosquera, Ashwin P. Patel, James M. Stark, Aravind Yadav   +9 more
wiley   +1 more source

Personalizing the Pediatric Hematology/Oncology Fellowship: Adapting Training for the Next Generation

Pediatric Blood &Cancer, EarlyView.
ABSTRACT The pediatric hematology‐oncology fellowship training curriculum has not substantially changed since its inception. The first year of training is clinically focused, and the second and third years are devoted to scholarship. However, this current structure leaves many fellows less competitive in the current job market, resulting in ...
Scott C. Borinstein, Melissa J. Rose, Scott Moerdler, Richard Ho   +3 more
wiley   +1 more source

Mechanisms of unconventional secretion of IL-1 family cytokines

Cytokine, 2015
One of the most poorly understood processes in cell biology is the peculiar ability of specific leaderless proteins to be secreted via ER/Golgi-independent mechanisms ('unconventional protein secretion'). One such leaderless protein is the major immune-activating cytokine, interleukin-1β (IL-1β).
Monteleone, Mercedes, Stow, Jennifer L., Schroder, Kate   +2 more
openaire   +4 more sources