Results 71 to 80 of about 2,293,083 (280)

Monocytes from patients with rheumatoid arthritis and type 2 diabetes mellitus display an increased production of interleukin (IL)-1\u3b2 via the nucleotide-binding domain and leucine-rich repeat containing family pyrin 3(NLRP3)-inflammasome activation: a possible implication for therapeutic decision in these patients [PDF]

, 2015
A better understanding about the mechanisms involved in the pathogenesis of type 2 diabetes mellitus (T2D) showed that inflammatory cytokines such as tumour necrosis factor (TNF) and interleukin (IL)-1\u3b2 play a pivotal role, mirroring data largely ...
Alvaro, S., Berardicurti, O., Carubbi, F., Ciccia, F., Cipriani, P., Di Benedetto, P., Giacomelli, R., Liakouli, V., Ruscitti, P., Triolo, G.   +9 more
core   +1 more source

Lifestyle Behaviors and Cardiotoxic Treatment Risks in Adult Childhood Cancer Survivors

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Higher doses of anthracyclines and heart‐relevant radiotherapy increase cardiovascular disease (CVD) risk. This study assessed CVD and CVD risk factors among adult childhood cancer survivors (CCSs) across cardiotoxic treatment risk groups and examined associations between lifestyle behaviors and treatment risks.
Ruijie Li, Raquel Revuelta Iniesta, Alan R. Barker, Dimitris Vlachopoulos, Tomáš Sláma, Christina Schindera, Fabiën N. Belle   +6 more
wiley   +1 more source

Neutrophil-Derived Proteases Escalate Inflammation through Activation of IL-36 Family Cytokines

Cell Reports, 2016
Recent evidence has strongly implicated the IL-1 family cytokines IL-36α, IL-36β, and IL-36γ as key initiators of skin inflammation. Similar to the other members of the IL-1 family, IL-36 cytokines are expressed as inactive precursors and require ...
Conor M. Henry, Graeme P. Sullivan, Danielle M. Clancy, Inna S. Afonina, Dagmar Kulms, Seamus J. Martin   +5 more
doaj   +1 more source

Role of Interleukin-33 in Immunity and Periodontal Inflammation-A Literature Review [PDF]

Journal of Clinical and Diagnostic Research, 2018
The Interleukin-33 (IL-33) is a member of IL-1 family discovered in the year of 2005. The Interleukin-1 (IL-1) family of cytokines is commonly encountered in chronic inflammatory diseases such as rheumatoid arthritis and periodontitis.
Sasi Kumar Karuppanan, Santhosh Sekar, Sakthi Saranya Devi   +2 more
doaj   +1 more source

Evaluating the levels of interleukin-1 family cytokines in sporadic amyotrophic lateral sclerosis [PDF]

, 2014
BACKGROUND: Amyotrophic lateral sclerosis (ALS) is a progressive motor neuron disease leading to the death of affected individuals within years. The involvement of inflammation in the pathogenesis of neurodegenerative diseases, including ALS, is ...
Barbara Borroni, Cecilia Carlesi, Diana Boraschi, Gabriele Siciliano, Ilaria Puxeddu, Paola Bossù, Paola Giungato, Paola Italiani, Paola Migliorini   +8 more
core   +1 more source

Cerebrospinal Fluid Liquid Biopsy Enables Targeted Therapy Without Tissue Diagnosis in Pediatric Low‐Grade Gliomas With BRAF V600E Mutation

Pediatric Blood &Cancer, EarlyView.
ABSTRACT We present two pediatric cases of pediatric low‐grade gliomas (PLGG) with BRAF V600E mutations diagnosed and monitored using cerebrospinal fluid (CSF) liquid biopsy analyzed via digital droplet PCR (ddPCR), without tissue biopsy. Both patients were treated with dabrafenib and trametinib and monitored through clinical assessments, magnetic ...
Hannah Sultan, Damien Faury, Alexander G. Weil, Harrison J. Westwick, Nada Jabado, Sébastien Perreault   +5 more
wiley   +1 more source

Diverse Control Mechanisms of the Interleukin-1 Cytokine Family

Frontiers in Cell and Developmental Biology, 2022
The majority of interleukin-1 (IL-1) family cytokines lack amino terminal secretion signals or transmembrane domains for secretion along the conventional biosynthetic pathway.
Charles L. Evavold, Jonathan C. Kagan
doaj   +1 more source

The microRNA-29 family in cartilage homeostasis and osteoarthritis [PDF]

, 2015
MicroRNAs have been shown to function in cartilage development and homeostasis, as well as in progression of osteoarthritis. The objective of the current study was to identify microRNAs involved in the onset or early progression of osteoarthritis and ...
A Kozomara, A Martinez-Sanchez, A Sorrentino, AJ Kriegel, AL Olex, Anne M. Delany, B Ma, BN Davis, C Yan, D Guerit, David A. Young, DJ Blasioli, DJ Hunter, DP Bartel, E Kozhemyakina, E Wienholds, EA Riordan, FE Nicolas, H Akiyama, H Pais, H Wang, Ian M. Clark, JL Mott, K Kapinas, K Kapinas, KA Dudek, KA Staines, KL Culley, KW Chong, L Jin, L Tuddenham, Linh T. T. Le, LT Le, M Cucchiarini, M Ha, M Himly, M Tan, M Yang, Matthew J. Barter, MB Goldring, MB Goldring, MH Bosch van den, MJ Barter, N Crowe, Natalie Crowe, Q Zhang, R Liu-Bryan, RK Davidson, S Liu, S Miyaki, S Shi, S Thysen, Simon T. Donell, SL Chia, SS Glasson, Tamas Dalmay, TE Swingler, Tonia L. Vincent, Tracey E. Swingler, V Korinek, V Lefebvre, W Kim, W Qin, XL Yuan, Y He, Y Nakamura, Y Nakamura, Y Zhuo   +67 more
core   +1 more source

Changes in Body Composition in Children and Young People Undergoing Treatment for Acute Lymphoblastic Leukemia: A Systematic Review and Meta‐Analysis

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Ongoing evidence indicates increased risk of sarcopenic obesity among children and young people (CYP) with acute lymphoblastic leukemia (ALL), often beginning early in treatment, persisting into survivorship. This review evaluates current literature on body composition in CYP with ALL during and after treatment.
Lina A. Zahed, Raquel Revuelta Iniesta, Mary Fewtrell, Julie Lanigan, Breeana Gardiner, Graeme O'Connor   +5 more
wiley   +1 more source

IL‐1, IL‐18, and IL‐33 families of cytokines

Immunological Reviews, 2008
Summary: The interleukin‐1 (IL‐1), IL‐18, and IL‐33 families of cytokines are related by mechanism of origin, receptor structure, and signal transduction pathways utilized. All three cytokines are synthesized as precursor molecules and cleaved by the enzyme caspase‐1 before or during release from the cell.
Arend, William P., Palmer-Lourenco, Gaby, Gabay, Cem   +2 more
openaire   +4 more sources