Results 81 to 90 of about 2,293,083 (280)

IL-36α Exerts Pro-Inflammatory Effects in the Lungs of Mice [PDF]

, 2012
Interleukin (IL-) 36 cytokines (previously designated as novel IL-1 family member cytokines; IL-1F5– IL-1F10) constitute a novel cluster of cytokines structurally and functionally similar to members of the IL-1 cytokine cluster.
Ewart, Susan L., Iwakura, Yoichiro, LeVine, Ann Marie, Medoff, Benjamin D., Ramadas, Ravisankar A.   +4 more
core   +3 more sources

Parent‐to‐Child Information Disclosure in Pediatric Oncology

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Despite professional consensus regarding the importance of open communication with pediatric cancer patients about their disease, actual practice patterns of disclosure are understudied. Extant literature suggests a significant proportion of children are not told about their diagnosis/prognosis, which is purported to negatively ...
Rachel A. Kentor, Flora Hoodin, Michelle Byrd, Kristin A. Kullgren, Leah LaLonde, Lauren Benkoske, Patrick Smith, Dawn Carson, Karen MacDonald, Susumu Inoue, Brenda Kitchen, Kate Gowans, Gregory A. Yanik   +12 more
wiley   +1 more source

Chevalier Jackson, M.D. (1865-1958): Il ne se repose jamais. [PDF]

, 2013
In the final year of the American Civil War, 1865, Chevalier Jackson was born on the 4th of November just outside Pittsburgh, Pennsylvania. The eldest of three sons of a poor, livestock-raising family, Jackson was raised in a period of social and ...
Cowan, MD, Scott W., Evans III, M.D., Nathaniel R., Nguyen, B.A., Phi D, Yeo, MD, Charles J.   +3 more
core   +1 more source

Predicting Chronicity in Children and Adolescents With Newly Diagnosed Immune Thrombocytopenia at the Timepoint of Diagnosis Using Machine Learning‐Based Approaches

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Objectives To identify predictors of chronic ITP (cITP) and to develop a model based on several machine learning (ML) methods to estimate the individual risk of chronicity at the timepoint of diagnosis. Methods We analyzed a longitudinal cohort of 944 children enrolled in the Intercontinental Cooperative immune thrombocytopenia (ITP) Study ...
Severin Kasser, Alice Bizeul, Meera Chitlur, Hugo Donato, Jelena Roganovic, Julia E. Vogt, Thomas Kühne   +6 more
wiley   +1 more source

Decoys and regulatory "receptors" of the IL-1/Toll Like Receptor superfamily

Frontiers in Immunology, 2013
Members of the IL-1 family play a key role in innate and adaptive immunity and in the pathogenesis of diverse diseases. Members of IL-1R like receptor (ILR) family include signalling molecules and negative regulators.
Cecilia eGarlanda, Federica eRiva, Eduardo eBonavita, Stefania eGentile, Alberto eMantovani, Alberto eMantovani   +5 more
doaj   +1 more source

Modulation of TGF-beta signaling by proinflammatory cytokines in articular chondrocytes. [PDF]

, 2007
OBJECTIVE: The normal structure and function of articular cartilage are the result of a precisely balanced interaction between anabolic and catabolic processes.
Jimenez, Sergio A., Roman-Blas, Jorge A., Stokes, David G.   +2 more
core   +1 more source

Blockade of T-cell activation by dithiocarbamates involves novel mechanisms of inhibition of nuclear factor of activated T cells. [PDF]

, 1997
Dithiocarbamates (DTCs) have recently been reported as powerful inhibitors of NF-kappaB activation in a number of cell types. Given the role of this transcription factor in the regulation of gene expression in the inflammatory response, NF-kappaB ...
Algarté M., Aramburu J., Baeuerle P. A., Baichwal V. R., Beals C. R., Beg A. A., Bessho R., Boise L. H., Burns G. F., Chuvpilo S. D., Cockerill P. N., Cockerill P. N., Cotter T. G., Crabtree G. R., Crabtree G. R., Durand D. B., Goldfeld A. E., Gómez del Arco P., Hibi M., Ho S. N., Ho S. N., Hodge M. R., Hoey T., Izquierdo M., Jain J., Jain J., Lee H. J., Liu J., Loh C., Los M., Luo C., Luo C., Luo C., Masuda E. S., Masuda E. S., Mauri N., McCaffrey P. G., Meyer M., Minden A., Muoz C., Muoz C., Nobel C. S. I., Northrop J. P., Prieschl E. E., Radler-Pohl A., Rao A., Reisinger E. C., Rooney J. W., Ruff V. A., Schenk H., Schreck R., Schreck R., Schreiber E., Schreiber S. L., Schulze-Osthoff K., Schulze-Osthoff K., Sen C. K., Shaw J. P., Shaw K. T., Shibasaki F., Spits H., Staal F. J. T., Szabo S. J., Sánchez-Mateos P., Timmerman L. A., Traenckner E.B., Truneh A., Van Antwerp D. J., Wang C., Weiss A., Wu M., Xanthoudakis S., Yano O.   +72 more
core   +3 more sources

Prognostic Impact of Treatment Modalities, Including Targeted Compartmental Radio‐Immunotherapy, in a Cohort of Neuroblastoma Patients With CNS Metastases at Relapse

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Introduction Neuroblastoma (NB) with central nervous system (CNS) metastases is rare at diagnosis, but occurs more often during relapse/progression. Patients with CNS metastases face a dismal prognosis, with no standardized curative treatment available.
Vicente Santa‐Maria Lopez, Anna Felip‐Badia, Marina Caballero‐Bellon, Nazaret Sanchez‐Sierra, Alicia Castañeda, Moira Garraus, Maite Gorostegui, Margarida Simão‐Rafael, Juan Pablo Muñoz, Marta Perez‐Somarriba, Salvador Mañe, Mariana Cecilia Planells, Sara Perez‐Jaume, Jaume Mora   +13 more
wiley   +1 more source

IL-27, but not IL-35, inhibits neuroinflammation through modulating GM-CSF expression [PDF]

, 2017
IL-27 and IL-35 are heterodimeric cytokines, members of the IL-12 family and considered to have immunomodulatory properties. Their role during neuroinflammation had been investigated using mutant mice devoid of either one of their subunits or lacking ...
Becher, Burkhard, Casella, Giacomo, Colombo, Federico, Degano, Massimo, Descamps, Hélène, Finardi, Annamaria, Furlan, Roberto, Maiorino, Chiara, Martino, Gianvito, Muzio, Luca, Patrone, Marco, Ruffini, Francesca   +11 more
core   +1 more source

Pathogenic Germline PALB2 and RAD50 Variants in Patients With Relapsed Ewing Sarcoma

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Approximately 10% of patients with Ewing sarcoma (EwS) have pathogenic germline variants. Here, we report two cases: first, a novel germline pathogenic variant in partner and localizer of BRCA2 (PALB2) in a patient with a late EwS relapse. Its impact on homologous recombination is demonstrated, and breast cancer risk is discussed.
Molly Mack, A. Carolina Tufino, Mohd Azrin Jamalruddin, Sreya Dey, Yinghong Pan, Elina Mukherjee, Jessica D. Daley, Julia Meade, Mahmoud Aarabi, Lisa Maurer, James Cooper, Kara A. Bernstein, Kelly M. Bailey   +12 more
wiley   +1 more source