Results 241 to 250 of about 65,138,242 (275)

Extracellular matrix remodeling and immune reprogramming drive residual tumor progression of liver cancer after incomplete microwave ablation

Molecular Oncology, EarlyView.
Incomplete microwave ablation (iMWA) of liver cancer triggers a biphasic progression in residual tumors. At Day 3, the microenvironment is characterized by acute inflammatory responses and extracellular matrix (ECM) remodeling. By Day 14, a profound shift occurs toward oncogenic signal transduction and immunosuppression, marked by macrophage ...
Yu Liu, Yubei He, Nikolaus Berndt, Michael Mülleder, Kathrin Textoris‐Taube, Jing Guo, Matthias Stechele, Justus Ramtke, Shraga Nahum Goldberg, Lynn Jeanette Savic   +9 more
wiley   +1 more source

Modulating IL-21-driven B cell responses in idiopathic inflammatory myopathies via inhibition of the JAK/STAT pathway. [PDF]

Arthritis Res Ther
Merino-Vico A, Kocyigit M, Frazzei G, Landman L, Boon L, van Leeuwen EM, Lundberg IE, van der Kooi AJ, Raaphorst J, van Hamburg JP, Tas SW.   +10 more
europepmc   +1 more source

Corrigendum: Translatability of findings from cynomolgus monkey to human suggests a mechanistic role for IL-21 in promoting immunogenicity to an anti-PD-1/IL-21 mutein fusion protein. [PDF]

Front Immunol
Kroenke MA, Manning MS, Zuch de Zafra CL, Zhang X, Cook KD, Archer M, Lolkema MP, Wang J, Hoofring S, Saini G, Aeffner F, Ahern E, Cabanas EG, Govindan R, Hui M, Gupta S, Mytych DT.   +16 more
europepmc   +1 more source

A novel feeder cell based on 4-1BBL and membrane-bound IL-21/IL-15 induce highly expansion and anti-tumor effect of natural killer cells. [PDF]

BMC Biotechnol
Gong S, Mei N, Wang J, Zhu J, Wang L, Lu X, He P, Chen W, Xi L, Bao Y, Wald DN, Fan X, Wang H.   +12 more
europepmc   +1 more source

IL-17 and IL-21: Their Immunobiology and Therapeutic Potentials. [PDF]

Immune Netw
Koh CH, Kim BS, Kang CY, Chung Y, Seo H.
europepmc   +1 more source

Corrigendum to 'B-cell activating factor and IL-21 levels predict treatment response in autoimmune hepatitis' [J Hepatol (2022) doi: 10.1016/j.jhepr.2022.100460]. [PDF]

JHEP Rep
Biewenga M, Heidt S, Vergunst M, Marijnissen CJM, de Man RA, van der Eijk AA, van der Meer AJ, Trouw LA, van Hoek B.   +8 more
europepmc   +1 more source

Combinatorial immunotherapy with anti-ROR1 CAR NK cells and an IL-21 secreting oncolytic virus against neuroblastoma. [PDF]

Mol Ther Oncol
Chu Y, Tian M, Saini U, Ayala-Cuesta J, Klose K, Mendelowitz AS, Foley K, Ozkaynak MF, Luo W, Cripe TP, Lee DA, Cassady KA, Cairo MS.   +12 more
europepmc   +1 more source

Metabolic reinvigoration of NK cells by IL-21 enhances immunotherapy against MHC-I deficient solid tumors

Wang Y, Huang C, Cai G, Andreatta M, Kurum A, Zhao Y, Feng B, Gao M, Carmona SJ, Zhou Z, Sun C, Guo Y, Tang L.   +12 more
europepmc   +1 more source

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Biology of IL‐21 and the IL‐21 receptor

Immunological Reviews, 2004
Summary:  Interleukin‐21 (IL‐21) is the newest member of the common γ‐chain family of cytokines, which includes IL‐2, IL‐4, IL‐7, IL‐9, IL‐13, and IL‐15. Its private receptor, IL‐21R, has been shown to activate the Janus kinase/signal transducers and activators of transcription signaling pathway upon ligand binding.
Devangi S, Mehta, Andrea L, Wurster, Michael J, Grusby   +2 more
openaire   +2 more sources

High IL-21 receptor expression and apoptosis induction by IL-21 in follicular lymphoma

Cancer Letters, 2007
We surveyed IL-21 receptor (IL-21R) in leukemia and lymphoma and found that follicular lymphoma cells showed exceptionally high IL-21R expression. Notably, IL-21 showed divergent effects depending on the cell origin: growth stimulation in Burkitt lymphoma cell lines and adult T cell leukemia/lymphoma cell lines but induction of apoptosis in B lymphoma ...
Norihiko, Akamatsu, Yasuaki, Yamada, Hiroo, Hasegawa, Koki, Makabe, Ryutaro, Asano, Izumi, Kumagai, Ken, Murata, Yoshitaka, Imaizumi, Kunihiro, Tsukasaki, Kazuto, Tsuruda, Kazuyuki, Sugahara, Sunao, Atogami, Katsunori, Yanagihara, Shimeru, Kamihira   +13 more
openaire   +2 more sources