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The role of IL-21 in hematological malignancies
Cytokine, 2011IL-21, the newest member of the common γ-chain family of cytokines, has pleiotropic biological effects through regulating a variety of immune cells. Recently, the role of IL-21 in the treatment of cancers has been widely investigated. Conducted phase I trials in metastatic malignant melanoma and renal cell carcinoma have shown that rIL-21 has a ...
Jingjing, Ma, Daoxin, Ma, Chunyan, Ji
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The role of IL-21 in immunity and cancer
Cancer Letters, 2015Interleukin-21 (IL-21), produced predominantly by CD4+ T cells and natural killer T (NKT) cells, is a newly discovered member of the common γ-chain family of cytokines. It has been implicated in many immunological processes and has been linked to autoimmune diseases, allergies and other inflammatory diseases.
Matthew R, Davis +4 more
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IL-21 Signaling in the Tumor Microenvironment
2020IL-21 is an immunomodulatory cytokine produced by natural killer (NK) cells and T cells that has pleiotropic roles in immune and nonimmune cells. IL-21 can modulate innate and specific immunity activities. It is a potent stimulator of T and natural killer cell-mediated antitumor immunity but also has pro-inflammatory functions in many tissues and is ...
Ghita, Chabab +2 more
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IL-21 and IL-21 Receptor: A New Cytokine Pathway Modulates Innate and Adaptive Immunity
Immunologic Research, 2003Interleukin (IL)-21 is a new member of the type I cytokine superfamily. Although it is most homologous to IL-15, it has a unique receptor chain, IL-21R, that pairs with the gamma-common cytokine receptor chain. The first experiments examining the biology of the IL-21 pathway reveal that it is a cytokine with effects on natural killer (NK) cells, T ...
Mary, Collins +2 more
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IL-21 and IL-21-producing T cells are involved in multiple sclerosis severity and progression
Immunology Letters, 2019Multiple sclerosis is a common neuroinflammatory disease of the central nervous system causing nervous system defects and severe physical disability. IL-21 is a proinflammatory cytokine produced mainly by Th-17 and Tfh cells which its exact role in MS was not yet clearly understood.
Tohid, Gharibi +9 more
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Immunology & Cell Biology, 2009
Despite intensive research, the pivotal factors that link abnormalities in permeability of the dermal barrier with inflammation and the generation of skin lesions in allergic dermatitis (AD) remain unknown. In a landmark paper published by Jin et al.1 in the Journal of Clinical Investigation, IL-21 is identified as a critical regulator of the processes
Foster, Paul S., Mattes, Joerg
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Despite intensive research, the pivotal factors that link abnormalities in permeability of the dermal barrier with inflammation and the generation of skin lesions in allergic dermatitis (AD) remain unknown. In a landmark paper published by Jin et al.1 in the Journal of Clinical Investigation, IL-21 is identified as a critical regulator of the processes
Foster, Paul S., Mattes, Joerg
openaire +1 more source