Results 71 to 80 of about 6,541,017 (281)
Pediatric Blood &Cancer, EarlyView.ABSTRACT Background Acute lymphoblastic leukemia (ALL) is the most common pediatric cancer, with an overall survival now surpassing 90% in developed countries. However, treatments are not without adverse effects. In this study, we apply the severe toxicity‐free survival (STFS) framework to determine the prevalence of 21 physician‐defined severe ...
Lane Collier +10 more
wiley +1 more source
IL-22 in vitro inhibits the apoptosis and promotes the proliferation of HSCs. [PDF]
, 2016 (A) Representative dot plots show the expression of 7-am-inoactinomycin D (7-AAD) and Annexin V in HSCs in vitro. Values of Annexin V+ and 7-AAD- represent the percentages of HSCs apoptotic cells.
Hui Ren (122548) +9 more
core +1 more source
Pediatric Blood &Cancer, EarlyView.ABSTRACT Background Type 1 plasminogen deficiency (PLGD‐1) is an ultra‐rare autosomal recessive disorder caused by variants in the PLG gene and affects approximately 1.6 individuals per million. The condition is characterized by decreased plasminogen levels and impaired function, resulting in fibrin‐rich lesions on mucous membranes throughout the body.
Charles Nakar +7 more
wiley +1 more source
IL-23p19, IL-22, and IL-18 mRNA expression in colonic ex vivo biopsies derived from C. jejuni strain 81–176 infected gnotobiotic mice lacking IL-23p19, IL-22 or IL-18. [PDF]
, 2016 (A) IL-23p19, (B) IL-22, and (C) IL-18 mRNA levels were determined in colonic ex vivo biopsies at day (d) 8 postinfection (black circles) by Real Time PCR and expressed in Arbitrary Units (fold expression).
Ulf B. Göbel (32408) +5 more
core +1 more source
IL-22Ra1 is induced during influenza infection by direct and indirect TLR3 induction of STAT1
Respiratory Research, 2019 Background Influenza attacks the epithelium of the lung, causing cell death and disruption of the epithelial barrier leading to fluid buildup in the lung and impairment of gas exchange.
K. D. Hebert +5 more
doaj +1 more source
Pediatric Blood &Cancer, EarlyView.ABSTRACT Introduction The use of herbal medical preparation (HMP) is rising among pediatric oncology patients, often to manage treatment‐related symptoms. Their effectiveness remains uncertain, and the risk of herb–drug interactions is underestimated.
Orianne Mahot +6 more
wiley +1 more source
IL-10 and IL-22 in Mucosal Immunity: Driving Protection and Pathology
Frontiers in Immunology, 2020 The barrier surfaces of the gastrointestinal tract are in constant contact with various microorganisms. Cytokines orchestrate the mucosal adaptive and innate immune cells in the defense against pathogens.
Hua-Xing Wei, Baolong Wang, Bofeng Li
doaj +1 more source
IL-22 Binding Protein Controls IL-22-Driven Bleomycin-Induced Lung Injury. [PDF]
Am J PatholThe high mortality rates of acute lung injury and acute respiratory distress syndrome challenge the field to identify biomarkers and factors that can be exploited for therapeutic approaches. IL-22 is a cytokine that has antibacterial and reparative properties in the lung.
Zhang Z +6 more
europepmc +3 more sources
Pediatric Blood &Cancer, EarlyView.ABSTRACT Pediatric radiation therapy presents unique challenges compared to adult treatments, including those of immobilization, potential need for sedation, and the critical importance of accurate, reproducible positioning. Additionally, heightened attention to imaging doses is necessary to minimize long‐term toxicity in survivors.
Parham Alaei +17 more
wiley +1 more source
Personalized Zebrafish Models for Fusion‐Positive Pediatric Sarcomas
Pediatric Blood &Cancer, EarlyView.ABSTRACT Clinical sequencing efforts have revolutionized our approaches to categorizing pediatric cancers in real time. This has dramatically improved our ability to profile pediatric tumors, identify actionable vulnerabilities, and influence clinical care.
Lisa H. Hall +2 more
wiley +1 more source