Results 121 to 130 of about 1,333,101 (244)

Linkage between IL-23 and coronary arterial lesions in pediatric patients with Kawasaki disease. [PDF]

Front Pediatr
Wei Y, Feng S, Wu J, Yang P, Su Y, Yi Q.
europepmc   +1 more source

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

Molecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed, Kerstin Huebner, Katharina Erlenbach‐Wuensch, Chuanpit Hampel, Daniela Thalheim, Adriana Vial‐Roehe, Bodee Nutho, Susanne Merkel, Arndt Hartmann, Pithi Chanvorachote, Regine Schneider‐Stock   +10 more
wiley   +1 more source

T cell and cytokine signatures as early predictors of response to IL-12/IL-23 inhibition in Crohn's disease. [PDF]

Front Immunol
Martín Arranz E, García-Ramirez L, Van Den Rym A, Suarez C, García-Solís B, Díaz-Iglesias N, López-Lera A, Corvillo F, Rueda García JL, Blanco-San Miguel P, Sánchez Azofra M, Poza Cordón J, Itan Y, López-Collazo E, Pérez de Diego R, Martín-Arranz MD.   +15 more
europepmc   +1 more source

IL-23 specifics in spondyloarthritis [PDF]

Nature Reviews Rheumatology, 2012
openaire   +1 more source

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

Mirikizumab: a landmark in IL-23-targeted therapy for ulcerative colitis. [PDF]

Ann Med Surg (Lond)
Iqbal MU, Shafquat E, Khan MO, Abu Nahla U.   +3 more
europepmc   +1 more source

Cis‐regulatory and long noncoding RNA alterations in breast cancer – current insights, biomarker utility, and the critical need for functional validation

Molecular Oncology, EarlyView.
The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués, Aracele Martinez‐Mendez, John Crown, Alex Eustace   +3 more
wiley   +1 more source

Investigation of the Relationships Between IL-12B and IL-23 Receptor Polymorphisms with Behçet's Disease in a Turkish Population. [PDF]

Int J Mol Sci
Arıkan S, Öztürk O, Atalay A, Atalay EÖ.   +3 more
europepmc   +1 more source

Methylation biomarkers can distinguish pleural mesothelioma from healthy pleura and other pleural pathologies

Molecular Oncology, EarlyView.
We developed and validated a DNA methylation–based biomarker panel to distinguish pleural mesothelioma from other pleural conditions. Using the IMPRESS technology, we translated this panel into a clinically applicable assay. The resulting two classifier models demonstrated excellent performance, achieving high AUC values and strong diagnostic accuracy.
Janah Vandenhoeck, Nele De Meulenaere, Thomas Vanpoucke, Joe Ibrahim, Dieter Peeters, Suresh Krishan Yogeswaran, Wen Wen, Paul Van Schil, Jeroen M. H. Hendriks, Jo Raskin, Jan van Meerbeeck, Guy Van Camp, Ken Op de Beeck   +12 more
wiley   +1 more source

Intraclonal Enrichment of IL-23 Receptor Complex Expression in the Proliferative Fraction of Chronic Lymphocytic Leukemia. [PDF]

Int J Mol Sci
Cardillo M, Ferrero F, Bertola N, Nano E, Massara R, Capra MC, Reverberi D, Colombo M, Cossu V, Ghiotto F, Ibatici A, Angelucci E, Neri A, Gentile M, Morabito F, Mazzarello AN, Ferrarini M, Fais F, Cutrona G.   +18 more
europepmc   +1 more source