Results 121 to 130 of about 1,375,213 (331)

RORγt inhibition selectively targets IL-17 producing iNKT and γδ-T cells enriched in Spondyloarthritis patients [PDF]

, 2019
Dysregulated IL-23/IL-17 responses have been linked to psoriatic arthritis and other forms of spondyloarthritides (SpA). ROR gamma t, the key Thelperl7 (Th17) cell transcriptional regulator, is also expressed by subsets of innate-like T cells, including ...
Coudenys, Julie, Cypers, Heleen, Decruy, Tine, Elewaut, Dirk, Gyselbrecht, Lieve, Harcken, Christian, Hoyt, Kathleen, Hughes, Robert, Jacques, Peggy, Labadia, Mark E., Martens, Liesbet, Mortier, Céline, Nabozny, Gerald, Piette, Yves, Saeys, Yvan, Schryvers, Nadia, Smith, Dustin, Turner, Michael, Van Calenbergh, Serge, Van den Bosch, Filip, Van Gassen, Sofie, Varkas, Gaëlle, Venken, Koen, Verheugen, Eveline, Wahle, Joseph, Wang, Chao-Ting, Wayne, Anita L., Wittoek, Ruth   +27 more
core   +3 more sources

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

Interleukin-17 regulates matrix metalloproteinase activity in human pulmonary tuberculosis. [PDF]

, 2017
Tuberculosis (TB) is characterized by extensive pulmonary matrix breakdown. Interleukin-17 (IL-17) is key in host defence in TB but its role in TB-driven tissue damage is unknown.
Aggarwal, Aguilo, Al Shammari, Aujla, Belton, Berg, Bermudez, Brinckerhoff, Chang, Cortez, Dheda, Dhiman, Domingo-Gonzalez, Elkington, Elkington, Elkington, Elkington, Elkington, Elkington, Fossiez, Freches, Fu, Gideon, Gopal, Hamburg, Hamburg, Happel, Hrabec, Huang, Jovanovic, Kubler, Leber, Matthews, Mayer-Barber, McAleer, McAllister, Miossec, Molet, Nuttall, O'Kane, O'Kane, Okamoto Yoshida, Ong, Oriss, Price, Qiao, Qiu, Rivas-Santiago, Ruddy, Sauty, Scriba, Singh, Singh, Sonnenberg, Torrado, Trajkovic, Treadwell, Volkman, Wang, Wickremasinghe, Wickremasinghe, Wong, Wozniak, Wu, Xu, Zijlstra   +65 more
core   +1 more source

TNF-anti-TNF Immune Complexes Inhibit IL-12/IL-23 Secretion by Inflammatory Macrophages via an Fc-dependent Mechanism [PDF]

, 2018
Felicia M. Bloemendaal, Pim J. Koelink, Karin A. van Schie, Theo Rispens, Charlotte P. Peters, Christianne J. Buskens, Jarmila D. van der Bilt, Willem A. Bemelman, Hannelie Korf, João Sabino, Cyriel Y. Ponsioen, Anje A. te Velde, Geert D’Haens, Séverine Vermeire, Gijs R. van den Brink, Manon E. Wildenberg   +15 more
openalex   +1 more source

The anti‐CRISPR protein AcrIE8.1 inhibits the type I‐E CRISPR‐Cas system by directly binding to the Cascade subunit Cas11

FEBS Letters, EarlyView.
In this study, we present the structure of AcrIE8.1, a previously uncharacterized anti‐CRISPR protein that inhibits the type I‐E CRISPR‐Cas system. Through a combination of structural and biochemical analyses, we demonstrate that AcrIE8.1 directly binds to the Cas11 subunit of the Cascade complex to inhibit the CRISPR‐Cas system.
Young Woo Kang, Hyun Ho Park
wiley   +1 more source

IL-23 Receptor Regulation by Let-7f in Human CD4+ Memory T Cells [PDF]

, 2011
Zhaoxia Li, Feng Wu, Steven R. Brant, John H. Kwon   +3 more
openalex   +1 more source

An intracellular transporter mitigates the CO2‐induced decline in iron content in Arabidopsis shoots

FEBS Letters, EarlyView.
This study identifies a gene encoding a transmembrane protein, MIC, which contributes to the reduction of shoot Fe content observed in plants under elevated CO2. MIC is a putative Fe transporter localized to the Golgi and endosomal compartments. Its post‐translational regulation in roots may represent a potential target for improving plant nutrition ...
Timothy Mozzanino, Meijie Li, Cécile Fizames, Mattia Adamo, Laurence Lejay, Christian Dubos, Matthieu Platre, Antoine Martin   +7 more
wiley   +1 more source

Assessment of the chemerin, IL-6, and IL-23 correlations and their impact on CRC progression: An observational study

, 2022
Julia Robotycka, Sylwia Mielcarska, Miriam Dawidowicz, Agnieszka Kula, Błażej Ochman, Bogusława Strzałkowska, Tomasz Niebudek, Dariusz Waniczek, Elżbieta Świętochowska   +8 more
openalex   +2 more sources

A Cre‐dependent lentiviral vector for neuron subtype‐specific expression of large proteins

FEBS Letters, EarlyView.
We designed a versatile and modular lentivector comprising a Cre‐dependent switch and self‐cleaving 2A peptide and tested it for co‐expression of GFP and a 2.8 kb gene of interest (GOI) in mouse cortical parvalbumin (PV+) interneurons and midbrain dopamine (TH+) neurons.
Weixuan Xue, Sandrine Picaud, Régine Hepp, Stéphanie Pons, Uwe Maskos, Bertrand Lambolez, Ludovic Tricoire   +6 more
wiley   +1 more source

The Effects of Adoptively Transferred IL-23/IL-18-Polarized Neutrophils on Tumor and Collagen-Induced Arthritis in Mice

Journal of Inflammation Research, 2021
Yifang Chen,1,* Yang Li,1,* Han Guo,1,2,* Zhaoqi Zhang,1,2 Jiayu Zhang,1,2 Xue Dong,1 Yi Liu,3 Yuan Zhuang,3 Yong Zhao1,4 1Department of State Key Laboratory of Membrane Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing ...
Chen Y, Li Y, Guo H, Zhang Z, Zhang J, Dong X, Liu Y, Zhuang Y, Zhao Y   +8 more
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