IL-17A, IL-17F and IL-23 in patients with rheumatoid arthritis
Научно-практическая ревматологияThe aim of the study was to determine the clinical and diagnostic value of interleukin (IL) 17A, IL-17F and IL-23 in rheumatoid arthritis (RA) patients in the advanced stage of the disease.Materials and methods.
Natalia A. Lapkina +6 more
doaj +1 more source
The role of IL-12/23 in T cell–related chronic inflammation: implications of immunodeficiency and therapeutic blockade [PDF]
, 2017 Anna Schurich +3 more
openalex +1 more source
A Th1 but not a Th17 response is present in the gastrointestinal involvement of Behçet's disease [PDF]
, 2010 OBJECTIVES: Behçet's disease has been historically classified as a Th1 disease. The recently described IL-17/IL-23 pathway seems to play an important role in many inflammatory diseases and in the intestinal abnormalities of AS and CD.
CICCIA, Francesco +6 more
core
IL-12p40 Homodimer Ameliorates Experimental Autoimmune Arthritis [PDF]
IL-23 is the key cytokine that induces the expansion of Th17 cells. It is composed of p19 and p40 subunits of IL-12. The p40 subunit binds competitively to the receptor of IL-23 and blocks its activity.
Cho, ML +14 more
core +1 more source
Function‐driven design of a surrogate interleukin‐2 receptor ligand
FEBS Letters, EarlyView.Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang +9 more
wiley +1 more source
Response to: 'IL-23 expression and activation of autophagy in synovium and PBMCs of HLA-B27 positive patients with ankylosing spondylitis' by Neerinckx et al. [PDF]
, 2014 ALESSANDRO, Riccardo +2 more
core +1 more source
Association between Interleukin-23 Receptor R381Q Gene Polymorphism and Asthma [PDF]
, 2015 The SNP (rs11209026, Arg381Gln, R381Q) in the IL-23 receptor (IL23R) confers protection against multiple inflammatory diseases, representing one of the most significant human genetic polymorphisms in inflammatory diseases. We, therefore, investigated the
Ganjalikhani Hakemi, Mazdak. +5 more
core +1 more source
Time after time – circadian clocks through the lens of oscillator theory
FEBS Letters, EarlyView.Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo +2 more
wiley +1 more source
European Medical Journal Dermatology, 2019 Psoriasis is a chronic, immune-mediated skin condition with systemic involvement, frequently requiring long-term treatment. At present, there are 11 biologic agents available for the treatment of moderate-to-severe psoriasis, which target specific ...
Sima D. Amin +4 more
doaj