Results 41 to 50 of about 1,375,213 (331)

Elevated testosterone on immunoassay in a patient with metastatic prostate cancer following androgen deprivation therapy and bilateral orchiectomy

Urology Case Reports, 2021
We present the case of an 83-year-old man with metastatic prostate cancer who had testosterone levels reading above castration range despite appropriate medical and surgical castration. Mass spectrometry was performed to confirm presence of testosterone,
Arjun Sarkar, BS, Mohammad Rashid Siddiqui, MD, Richard J. Fantus, MD, Maha Hussain, MD, Joshua A. Halpern, MD, MS, Ashley E. Ross, MD, PhD   +5 more
doaj   +1 more source

IL-23 in Colitis: Targeting the Progenitors [PDF]

Immunity, 2012
Inflammatory bowel disease (IBD) is a chronic inflammatory disease of the gastrointestinal tract. In this issue of Immunity, Griseri et al. (2012) show that IL-23-induced dysregulation of hematopoietic stem and progenitor cells contributes to the pathogenesis of two IBD models.
Tang, Ce, Iwakura, Yoichiro
openaire   +2 more sources

RNA aptamer delivery through intact human skin [PDF]

, 2018
It is generally recognised that only relatively small molecular weight (typically 100,000-fold) and aptamer integrity was confirmed using an oligonucleotide precipitation assay.
Brown, M. B., Cote-Sierra, J., Demock, K., Donahue, C., Killough, J., Lenn, J. D., Neil, J., Pendergrast, P. S., Rubenstein, D., Smith, S. H., Therrien, J.-P., Tibbetts, C. V., Williams, Adrian   +12 more
core   +3 more sources

Association of the virulence factors of Helicobacter pylori and gastric mucosal interleukin-17/23 mRNA expression in dyspeptic patients [PDF]

, 2013
The molecular pathways that control Helicobacter pylori (Hp)-associated inflammatory reaction are complex, but locally induced cytokines and virulence factors seem to have a major role in maintaining the ongoing inflammation.
Azadegan, Fatemeh, Bagheri, Nader, Rafieian-Kopaei, Mahmoud, Rahimian, Ghorbanali, Salimzadeh, Loghman, Shirzad, Hedayatollah, Taghikhani, Afshin   +6 more
core   +3 more sources

Efficacy and safety of IL-23p19 and IL-12/23p40 inhibitors in moderate-to-severe Crohn’s disease: a systematic review and network meta-analysis

Annals of Medicine
Background Interleukin (IL)-23 inhibitors—including IL-23p19 inhibitors (guselkumab, mirikizumab, risankizumab) and the IL-12/23p40 inhibitor ustekinumab—are emerging treatments for Crohn’s disease (CD), but comparative data among them remain limited ...
Motoki Kaneko, Atsushi Sakuraba
doaj   +1 more source

Il Fibroblast Growth Factor-23 (FGF-23)

Giornale di Clinica Nefrologia e Dialisi, 2018
Negli ultimi due decenni, l'identificazione delle proprietà biologiche del Fibroblast Growth Factor 23 (FGF23) ha notevolmente ampliato le conoscenze sulla regolazione endocrina e paracrina dell'omeostasi dei fosfati e sulle relazioni intercorrenti tra ...
D. Rendina, G. De Filippo, R. Muscariello, F. De Pascale, P. Strazzullo   +4 more
doaj   +1 more source

IL-1 regulates the IL-23 response to wheat gliadin, the etiologic agent of Celiac Disease [PDF]

, 2008
Celiac disease (CD) is an autoimmune disease prevalent in ~1% of the general population. CD is unique because both the major genetic (Human Leukocyte Antigen-DQ2/DQ8 alleles) and etiologic factors (dietary glutens) for susceptibility are known.
Alessio Fasano, Dean L. Mann, Kristina M. Harris   +2 more
core   +1 more source

A Quality Improvement Initiative to Standardize Pneumocystis jirovecii Pneumonia Prophylaxis in Pediatric Patients With Solid Tumors

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Pediatric patients with extracranial solid tumors (ST) receiving chemotherapy are at an increased risk for Pneumocystis jirovecii pneumonia (PJP). However, evidence guiding prophylaxis practices in this population is limited. A PJP‐related fatality at our institution highlighted inconsistent prescribing approaches and concerns about
Kriti Kumar, Denise M. Connolly, Ellen Kellington, Elyse Zelunka, Karla Kerrigan, Furqan Shaikh, Paul C. Nathan, Meredith S. Irwin, Sarah Cohen‐Gogo   +8 more
wiley   +1 more source

Expanding Diversity in Molecular Structures and Functions of the IL-6/IL-12 Heterodimeric Cytokine Family

Frontiers in Immunology, 2016
The interleukin (IL)-6/IL-12 family cytokines have pleiotropic functions and play critical roles in multiple immune responses. This cytokine family has very unique characteristics in that they are composed of two distinct subunits forming a heterodimer ...
Hideaki Hasegawa, Izuru Mizoguchi, Yukino Chiba, Mio Ohashi, Mingli Xu, Takayuki Yoshimoto   +5 more
doaj   +1 more source

Sickle Cell Disease Is an Inherent Risk for Asthma in a Sibling Comparison Study

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Introduction Sickle cell disease (SCD) and asthma share a complex relationship. Although estimates vary, asthma prevalence in children with SCD is believed to be comparable to or higher than the general population. Determining whether SCD confers an increased risk for asthma remains challenging due to overlapping symptoms and the ...
Suhei C. Zuleta De Bernardis, Okeleji Olayinka, Mariam Z. Quraishi, Lakshmi V. Srivaths, Deborah L. Brown, Neethu M. Menon, Ricardo A. Mosquera, Ashwin P. Patel, James M. Stark, Aravind Yadav   +9 more
wiley   +1 more source