An innate IL-25-ILC2-MDSC axis creates a cancer-permissive microenvironment for <i>Apc</i> mutation-driven intestinal tumorigenesis. [PDF]
Sci Immunol, 2022 Interleukin-25 (IL-25) and group 2 innate lymphoid cells (ILC2s) defend the host against intestinal helminth infection and are associated with inappropriate allergic reactions.
Jou E +12 more
europepmc +2 more sources
IL-25 Induced ROS-Mediated M2 Macrophage Polarization via AMPK-Associated Mitophagy. [PDF]
Int J Mol Sci, 2021 Interleukin (IL)-25 is a cytokine released by airway epithelial cells responding to pathogens. Excessive production of reactive oxygen species (ROS) leads to airway inflammation and remodeling in asthma. Mitochondria are the major source of ROS.
Tsai ML +8 more
europepmc +2 more sources
Tuft cell IL-17RB restrains IL-25 bioavailability and reveals context-dependent ILC2 hypoproliferation. [PDF]
Nat ImmunolThe tuft cell–group 2 innate lymphoid cell (ILC2) circuit orchestrates rapid type 2 responses upon detecting microbially derived succinate and luminal helminths.
Feng X +19 more
europepmc +2 more sources
Tuft cell-produced cysteinyl leukotrienes and IL-25 synergistically initiate lung type 2 inflammation. [PDF]
Sci Immunol, 2021 Aeroallergen sensing by airway epithelial cells can trigger pathogenic immune responses leading to chronic type 2 inflammation, the hallmark of airway diseases such as asthma.
Ualiyeva S +11 more
europepmc +2 more sources
The Alarmin Triad-IL-25, IL-33, and TSLP-Serum Levels and Their Clinical Implications in Chronic Spontaneous Urticaria. [PDF]
Int J Mol SciThis study delves into the critical role of alarmins in chronic spontaneous urticaria (CSU), focusing on their impact on disease severity and the quality of life (QoL) of patients.
Dobrican-Băruța CT +6 more
europepmc +2 more sources
The IL-25-dependent tuft cell circuit driven by intestinal helminths requires macrophage migration inhibitory factor (MIF). [PDF]
Mucosal Immunol, 2022 Macrophage migration inhibitory factor (MIF) is a key innate immune mediator with chemokine- and cytokine-like properties in the inflammatory pathway. While its actions on macrophages are well-studied, its effects on other cell types are less understood.
Varyani F +11 more
europepmc +2 more sources
Elevated Levels of IL-33, IL-17 and IL-25 Indicate the Progression from Chronicity to Hepatocellular Carcinoma in Hepatitis C Virus Patients. [PDF]
Pathogens, 2022 Hepatitis C virus (HCV) is one of the most epidemic viral infections in the world. Three-quarters of individuals infected with HCV become chronic. As a consequence of persistent inflammation, a considerable percentage of chronic patients progress to ...
Askoura M +9 more
europepmc +2 more sources
IL-25-induced shifts in macrophage polarization promote development of beige fat and improve metabolic homeostasis in mice. [PDF]
PLoS Biol, 2021 Beige fat dissipates energy and functions as a defense against cold and obesity, but the mechanism for its development is unclear. We found that interleukin (IL)-25 signaling through its cognate receptor, IL-17 receptor B (IL-17RB), increased in adipose ...
Li L +12 more
europepmc +2 more sources
Investigating the relationship between the severity of coronary artery disease and inflammatory factors of MHR, PHR, NHR, and IL-25. [PDF]
Med J Islam Repub Iran, 2021 Background: Coronary artery disease (CAD), as a most common cause of death, is mainly caused by atherosclerosis. Due to the role of inflammation in the process of atherosclerosis, in the present study, the relationship between the severity of coronary ...
Manoochehri H +4 more
europepmc +2 more sources
Fecal Microbiota Transplantation Increases Colonic IL-25 and Dampens Tissue Inflammation in Patients with Recurrent Clostridioides difficile. [PDF]
mSphere, 2021 Fecal microbiota transplantation (FMT) is an effective treatment for C. difficile infection for most patients; however, introducing a complex mixture of microbes also has had unintended consequences for some patients.
Jan N +7 more
europepmc +2 more sources