Results 41 to 50 of about 1,155,232 (268)

Emerging Topical and Systemic JAK Inhibitors in Dermatology [PDF]

, 2019
Accumulating data on cellular and molecular pathways help to develop novel therapeutic strategies in skin inflammation and autoimmunity. Examples are psoriasis and atopic dermatitis, two clinically and immunologically well-defined disorders.
Ghoreschi, Kamran, Meier, Katharina, Solimani, Farzan   +2 more
core   +1 more source

Increased levels of interleukin 31 (IL-31) in osteoporosis [PDF]

BMC Immunology, 2015
Several inflammatory cytokines play a key part in the induction of osteoporosis. Until now, involvement of the Th2 cytokine interleukin-31 (IL-31) in osteoporosis hadn't yet been studied. IL-31 is a proinflammatory cytokine mediating multiple immune functions, whose involvement in a wide range of diseases, such as atopic dermatitis, inflammatory bowel ...
GINALDI, Lia, DE MARTINIS, MASSIMO MARIA MARCELLO, Ciccarelli F, Saitta S, Imbesi S, Mannucci C, Gangemi S.   +6 more
openaire   +4 more sources

Use of Cytopoint in the Allergic Dog

Frontiers in Veterinary Science, 2022
Allergic dermatitis is the most common type of skin disease in dogs. Of all dogs, 20 to 30% present with some type of allergic dermatitis. Pruritus is one of the most important signs of allergic dermatitis and is often the most challenging to control ...
Margaret Gober, Andrew Hillier, Manuel A. Vasquez-Hidalgo, Manuel A. Vasquez-Hidalgo, Deborah Amodie, Martha A. Mellencamp   +5 more
doaj   +1 more source

Atopische Dermatitis: IL-31 reguliert Keratinozytendifferenzierung [PDF]

Allergo Journal, 2012
Von einer atopischen Dermatitis sind in Industrielandern 10–20 % der Kinder und 1–3% der Erwachsenen betroffen. Hautbiopsien der Patienten weisen eine erhohte Expression des Interleukins IL-31 auf, die physiologische Relevanz von IL-31 ist jedoch bislang ungeklart.
openaire   +1 more source

Role of genetic aspect in pathogenesis of atopic dermatitis [PDF]

, 2013
The pathogenesis of atopic dermatitis (AD) is a very complicated process that involves an intricate array of molecules. Nowadays it is generally accepted that cytokines play an important role in the progression of the clinical presentation of atopic ...
Wesserling Martyna
core   +1 more source

Interleukin-31: A Pro-inflammatory Oriented Cytokine

Frontiers in Bioscience-Landmark
Type 2 immunity is represented by T helper 2 (Th2) lymphocytes and the cytokines produced downstream (Interleukin (IL)-4, IL-13, IL-31). They are increasingly recognized as pivotal mediators in the pathogenesis of immune-mediated dermatological ...
Giuseppe Murdaca, Francesca Paladin, Andrea Orsi, Sebastiano Gangemi   +3 more
doaj   +1 more source

TMEM184b is necessary for IL-31 induced itch [PDF]

, 2020
AbstractNociceptive and pruriceptive neurons in the dorsal root ganglia (DRG) convey sensations of pain and itch to the spinal cord, respectively. One subtype of mature DRG neurons, comprising about 5% of neurons in the ganglia, is responsible for sensing mediators of acute itch and atopic dermatitis, including the cytokine IL-31.
Erik G. Larsen, Tiffany S. Cho, Matthew L. McBride, Jing Feng, Bhagyashree Manivannan, Cynthia Madura, Nathaniel E. Klein, Elizabeth B. Wright, Hector D. Garcia-Verdugo, Chelsea Jarvis, Rajesh Khanna, Hongzhen Hu, Tally M. Largent-Milnes, Martha R.C. Bhattacharya   +13 more
openaire   +1 more source

Eosinophils are a Major Source of Interleukin-31 in Bullous Pemphigoid

Acta Dermato-Venereologica, 2018
Bullous pemphigoid (BP) is characterized by substantial skin and blood eosinophilia as well as intensive pruritus. Since the pruritogenic cytokine interleukin (IL)-31 is increased in inflammatory skin diseases the aim of this study was to determine ...
Urda Rüdrich, Manuela Gehring, Eleni Papakonstantinou, Anja Illerhaus, Judith Engmann, Alexander Kapp, Karin Hartmann, N. Helge Meyer, Bernhard F. Gibbs, Ulrike Raap   +9 more
doaj   +1 more source

Deletion of Tsc2 in nociceptors reduces target innervation, ion channel expression, and sensitivity to heat [PDF]

, 2018
The mechanistic target of rapamycin complex 1 (mTORC1) is known to regulate cellular growth pathways, and its genetic activation is sufficient to enhance regenerative axon growth following injury to the central or peripheral nervous systems.
Carlin, Dan, Cavalli, Valeria, Gereau, Robert W, Golden, Judith P, Mogha, Amit, Monk, Kelly R, Samineni, Vijay K   +6 more
core   +2 more sources

IL-31: A new key player in dermatology and beyond [PDF]

Journal of Allergy and Clinical Immunology, 2018
IL-31 is a novel cytokine expressed in many human tissues and involved mainly in TH2-weighted inflammation. IL-31 signals through a receptor complex consisting of IL-31 receptor α and oncostatin M receptor β. The available data show that IL-31 is strongly linked with chronic pruritic skin disorders, such as atopic eczema, and represents a novel target ...
Işın Sinem, Bağci, Thomas, Ruzicka
openaire   +2 more sources