Results 111 to 120 of about 1,087,614 (283)

Revealing the structure of land plant photosystem II: the journey from negative‐stain EM to cryo‐EM

FEBS Letters, EarlyView.
Advances in cryo‐EM have revealed the detailed structure of Photosystem II, a key protein complex driving photosynthesis. This review traces the journey from early low‐resolution images to high‐resolution models, highlighting how these discoveries deepen our understanding of light harvesting and energy conversion in plants.
Roman Kouřil
wiley   +1 more source

IL-33 regulates cytokine production and neutrophil recruitment via the p38 MAPK-activated kinases MK2/3 [PDF]

, 2019
IL‐33 is an IL‐1‐related cytokine that can act as an alarmin when released from necrotic cells. Once released, it can target various immune cells including mast cells, innate lymphoid cells and T cells to elicit a Th2‐like immune response.
Adachi, Ali, Ananieva, Andrade, Arthur, Benjamin, Cayrol, Chang, Clement, Darragh, Drube, Drube, Elcombe, Enoksson, Enoksson, Filippo, Funakoshi-Tago, Galloway, Gopfert, Helft, Hitti, Ho, Hochdorfer, Hodson, Huang, Hyatt, Iikura, Junttila, Kotlyarov, Kroeger, Liew, Lohning, Luthi, MacKenzie, Maitra, Marchese, Martin, McCoy, McDonald, McGuire, McGuire, Mjosberg, Molofsky, Monticelli, Moritz, Moulin, Naqvi, Neininger, Ottonello, Patial, Petri, Pozuelo, Qiu, Ronkina, Ronkina, Ross, Sanduja, Schiering, Schmidlin, Schmitz, Soukup, Stokoe, Sutavani, Suzuki, Swamydas, Taylor, Tung, Wiggin, Xiao, Xu, Zaru   +70 more
core   +2 more sources

Mapping the evolution of mitochondrial complex I through structural variation

FEBS Letters, EarlyView.
Respiratory complex I (CI) is crucial for bioenergetic metabolism in many prokaryotes and eukaryotes. It is composed of a conserved set of core subunits and additional accessory subunits that vary depending on the organism. Here, we categorize CI subunits from available structures to map the evolution of CI across eukaryotes. Respiratory complex I (CI)
Dong‐Woo Shin, Tingting Chen, James A. Letts   +2 more
wiley   +1 more source

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Association of IL‐33 in modeling type‐2 airway inflammation and pulmonary emphysema in mice

Immunity, Inflammation and Disease
We developed pulmonary emphysema and a type 2 airway inflammation overlap mouse model. The bronchoalveolar lavage (BAL) interleukin 13 (IL‐13), IL‐4, and IL‐5 levels in the overlap model were higher than in the pulmonary emphysema model and lower than in
Chika Miyaoka, Masato Watanabe, Keitaro Nakamoto, Yuki Yoshida, Aya Hirata, Jumpei Aso, Hiroki Nunokawa, Manabu Ishida, Koujiro Honda, Saori Takata, Takeshi Saraya, Haruyuki Ishii   +11 more
doaj   +1 more source

Sexual maturation protects against development of lung inflammation through estrogen. [PDF]

, 2016
Increasing levels of estrogen and progesterone are suggested to play a role in the gender switch in asthma prevalence during puberty. We investigated whether the process of sexual maturation in mice affects the development of lung inflammation in ...
Boorsma, Carian E, Draijer, Christina, Greene, Catherine M, Hylkema, Machteld N, Klok, Pieter A, Melgert, Barbro N, Postma, Dirkje S, Robbe, Patricia, Timens, Wim   +8 more
core   +1 more source

By dawn or dusk—how circadian timing rewrites bacterial infection outcomes

FEBS Letters, EarlyView.
The circadian clock shapes immune function, yet its influence on infection outcomes is only beginning to be understood. This review highlights how circadian timing alters host responses to the bacterial pathogens Salmonella enterica, Listeria monocytogenes, and Streptococcus pneumoniae revealing that the effectiveness of immune defense depends not only
Devons Mo, Catherine S. Palmer, Jacqueline M. Kimmey   +2 more
wiley   +1 more source

MicroRNA regulation of type 2 innate lymphoid cell homeostasis and function in allergic inflammation. [PDF]

, 2017
MicroRNAs (miRNAs) exert powerful effects on immunity through coordinate regulation of multiple target genes in a wide variety of cells. Type 2 innate lymphoid cells (ILC2s) are tissue sentinel mediators of allergic inflammation.
Ansel, K Mark, Baumjohann, Dirk, Happ, Hannah C, Locksley, Richard M, Pua, Heather H, Schneider, Christoph, Singh, Priti B, von Moltke, Jakob   +7 more
core   +2 more sources

Liquid Hydroxyurea (Xromi) for Children With Sickle Cell Anemia: A New Solution Compounding Existing Problems

Pediatric Blood &Cancer, EarlyView.
Alexandra Power‐Hays, Charles T. Quinn
wiley   +1 more source

Hematopoietic (stem) cells—The elixir of life?

FEBS Letters, EarlyView.
The aging of HSCs (hematopoietic stem cells) and the blood system leads to the decline of other organs. Rejuvenating aged HSCs improves the function of the blood system, slowing the aging of the heart, kidney, brain, and liver, and the occurrence of age‐related diseases.
Emilie L. Cerezo, Jonah Anderson, Emilie Dinh Vedrenne, Noël Yeh Martín, Jette Lengefeld   +4 more
wiley   +1 more source