Results 101 to 110 of about 3,545,338 (242)
Blockade of IL‐33 signalling attenuates osteoarthritis
Clinical & Translational Immunology, 2020 Objectives Osteoarthritis (OA) is the most common form of arthritis characterised by cartilage degradation, synovitis and pain. Disease modifying treatments for OA are not available.
Zengliang He +7 more
doaj +1 more source
Therapeutic Apheresis and Dialysis, EarlyView.ABSTRACT Background Japan has one of the highest dialysis prevalence rates worldwide and a shrinking, aging population. Whether dialysis burden has entered a sustained post‐peak phase or whether recent declines partly reflect pandemic‐related disruptions remains uncertain.
Hatice Şahin +2 more
wiley +1 more source
IL-1 Family Cytokine Regulation of Vascular Permeability and Angiogenesis
Frontiers in Immunology, 2019 The IL-1 family of cytokines are well-known for their primary role in initiating inflammatory responses both in response to and acting as danger signals.
Erin Fahey +4 more
doaj +1 more source
Therapeutic Apheresis and Dialysis, EarlyView.ABSTRACT Introduction Peritoneal dialysis (PD) is an established home‐based kidney replacement therapy (KRT), but its uptake remains low in Japan. We evaluated whether individualized education in a dedicated outpatient clinic was associated with the initiation of PD.
Yasuko Ito +7 more
wiley +1 more source
Organoids in pediatric cancer research
FEBS Letters, EarlyView.Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley +1 more source
Frontiers in ImmunologyInterleukin-5 (IL-5) is central to eosinophil differentiation, survival, and activation. Subsequent studies confirmed IL-5 receptor expression and mapped downstream signaling, showing that IL-5 promotes not only survival but also trafficking and effector
Hisashi Sasaki +4 more
doaj +1 more source
IL-33, Imprimatur of Adipocyte Thermogenesis [PDF]
Cell, 2016 Chawla and colleagues find that interleukin-33 is a critical controller of brown and beige adipocyte thermogenesis. Its primary impact is on the splicing of transcripts encoding uncoupling protein-1, resulting in uncoupled respiration and effective heat generation. Interleukin-33 acts perinatally to ensure adaptive thermogenesis lifelong.
openaire +2 more sources
Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?
FEBS Letters, EarlyView.This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes +3 more
wiley +1 more source
3.3. Il mondo dell’arte come istituzione sociale
Rivista di Estetica, 2012 The essay has two main aims: (a) to provide an explanation of the ontology on which is based the concept of the “art world”; and, on the basis of that account, (b) to inquire whether the so-called Institutional Theories of Art are well founded.
Tiziana Andina
doaj +1 more source
Longitudinal changes in the expression of IL-33 and IL-33 regulated genes in relapsing remitting MS
PLOS ONE, 2018 We tested the hypothesis that the expression of IL-33 in MS is dynamic and is likely to reflect the clinical and radiological changes during the course of RRMS.MS with either clinical or radiological relapses were recruited for the study and followed for one year.
Subramaniam Sriram +5 more
openaire +4 more sources