Results 81 to 90 of about 6,663,297 (230)
Organoids in pediatric cancer research
FEBS Letters, EarlyView.Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley +1 more source
Charakterisierung von Innterleukin-33 und dem IL-33 Rezeptor Komplex [PDF]
, 2009 Two pivotal aspects of the IL-33 system are characterized in this study: First the composition and function of the IL-33 receptor complex on IL-33 responder cells and second the generation of biologically active IL-33 by the IL-33 producer cell.
Ali, Shafaqat
core +1 more source
Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?
FEBS Letters, EarlyView.This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes +3 more
wiley +1 more source
, 2009 In mice, interleukin-18 (IL-18) regulates Th1- or Th2-type immune responses depending on the cytokine environment and effector cells involved, and the ST2-ligand, IL-33, primarily promotes an allergic phenotype. Human basophils, major players in allergic
Pecaric-Petkovic, Tatjana +9 more
core +1 more source
Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation
FEBS Letters, EarlyView.Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe +3 more
wiley +1 more source
IL-33 induces significant changes in cell surface expression.
, 2019 Box plots of normalized fold change for A) CD11b, B) CD18, C) CD66b, D) ICAM-1 after 4 hour stimulation with either IL-3, IL-5, IL-33, eotaxin-1 compared with unstimulated, represented by dotted line (n = 7–8).
Evelyn L. Angulo (7354019) +3 more
core +1 more source
FEBS Letters, EarlyView.Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes +4 more
wiley +1 more source
Frontiers in ImmunologyCD25 (IL-2 receptor alpha chain) is a key component of the high-affinity receptor for the IL-2 cytokine and regulates the proliferation, survival, and differentiation of immune cells.
Sruthi Vijaya Retnakumar +4 more
doaj +1 more source
IL-10 and IL-33 levels in plasma.
, 2016 The plasma from individuals with normal BMI (n = 17) and low BMI (n = 23, of which 9 were moderately malnourished and 14 were severely malnourished) was tested by Luminex for the levels of IL-10 and IL-33.
J. Raynes (3070401) +16 more
core +1 more source
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source