Results 61 to 70 of about 4,627,366 (384)
Single-Chain Soluble Receptor Fusion Proteins as Versatile Cytokine Inhibitors
Frontiers in Immunology, 2020 Cytokines are small secreted proteins that among many functions also play key roles in the orchestration of inflammation in host defense and disease.
Aurora Holgado +15 more
doaj +1 more source
Nuclear IL‐33/SMAD signaling axis promotes cancer development in chronic inflammation
EMBO Journal, 2021 Interleukin (IL)‐33 cytokine plays a critical role in allergic diseases and cancer. IL‐33 also has a nuclear localization signal. However, the nuclear function of IL‐33 and its impact on cancer is unknown. Here, we demonstrate that nuclear IL‐33‐mediated
J. H. Park +6 more
semanticscholar +1 more source
IL-33 and IL-18 in Inflammatory Bowel Disease Etiology and Microbial Interactions
Frontiers in Immunology, 2019 The IL-1 cytokines are a newly expanded family, with each of its 11 members playing an important role in health and disease. Typically acting as pro- or anti-inflammatory mediators of first-line innate immunity, their production is particularly important
Michelle A. Williams +2 more
doaj +1 more source
Interleukin-33 regulates tissue remodelling and inhibits angiogenesis in the eye [PDF]
, 2016 Age-related macular degeneration (AMD) is the leading cause of central vision loss worldwide. Loss of retinal pigment epithelium (RPE) is a major pathological hallmark in AMD with or without pathological neovascularization.
Allakhverdi +47 more
core +3 more sources
JCI Insight, 2021 Interleukin-33 (IL-33), a nuclear alarmin released during cell death, exerts context-specific effects on adaptive and innate immune cells eliciting potent inflammatory responses.
Spiros Georgakis +14 more
semanticscholar +1 more source
Interleukin-31: A Pro-inflammatory Oriented Cytokine
Frontiers in Bioscience-LandmarkType 2 immunity is represented by T helper 2 (Th2) lymphocytes and the cytokines produced downstream (Interleukin (IL)-4, IL-13, IL-31). They are increasingly recognized as pivotal mediators in the pathogenesis of immune-mediated dermatological ...
Giuseppe Murdaca +3 more
doaj +1 more source
Diagnostics, 2023 Interleukins are considered to be potential therapeutic targets that can alter the prognosis and disease progression of IBD. IL-21 has proven to be involved in effector Th1, Th2 and Th17 responses.
Alexandros Toskas +5 more
doaj +1 more source
The TAK1→IKKβ→TPL2→MKK1/MKK2 Signaling Cascade Regulates IL-33 Expression in Cystic Fibrosis Airway Epithelial Cells Following Infection by Pseudomonas aeruginosa [PDF]
, 2016 In cystic fibrosis (CF), chronic respiratory infections result in an exaggerated and uncontrolled inflammatory response that ultimately lead to a decrease in pulmonary function.
Raquel Farias, Simon Rousseau
core +2 more sources
IL-33-activated ILC2s induce tertiary lymphoid structures in pancreatic cancer
NatureTertiary lymphoid structures (TLSs) are de novo ectopic lymphoid aggregates that regulate immunity in chronically inflamed tissues, including tumours. Although TLSs form due to inflammation-triggered activation of the lymphotoxin (LT)–LTβ receptor (LTβR)
M. Amisaki +35 more
semanticscholar +1 more source
Role of IL‐25, IL‐33, and TSLP in triggering united airway diseases toward type 2 inflammation
Allergy. European Journal of Allergy and Clinical Immunology, 2020 Under the concept of "united airway diseases," the airway is a single organ wherein upper and lower airway diseases are commonly comorbid. The upper and lower airways are lined with respiratory epithelium that plays a vital role in immune surveillance ...
H. Hong +4 more
semanticscholar +1 more source