Results 61 to 70 of about 3,545,338 (242)

Role of IL‐25, IL‐33, and TSLP in triggering united airway diseases toward type 2 inflammation

Allergy. European Journal of Allergy and Clinical Immunology, 2020
Under the concept of "united airway diseases," the airway is a single organ wherein upper and lower airway diseases are commonly comorbid. The upper and lower airways are lined with respiratory epithelium that plays a vital role in immune surveillance ...
H. Hong, Shumin Liao, Fenghong Chen, Qintai Yang, D. Wang   +4 more
semanticscholar   +1 more source

Nuclear IL‐33/SMAD signaling axis promotes cancer development in chronic inflammation

EMBO Journal, 2021
Interleukin (IL)‐33 cytokine plays a critical role in allergic diseases and cancer. IL‐33 also has a nuclear localization signal. However, the nuclear function of IL‐33 and its impact on cancer is unknown. Here, we demonstrate that nuclear IL‐33‐mediated
J. H. Park, A. Ameri, Kaitlin E. Dempsey, Danielle N Conrad, M. Kem, M. Mino‐Kenudson, S. Demehri   +6 more
semanticscholar   +1 more source

IL-33 reduces the development of atherosclerosis [PDF]

Journal of Experimental Medicine, 2008
Atherosclerosis is a chronic inflammatory disease of the vasculature commonly leading to myocardial infarction and stroke. We show that IL-33, which is a novel IL-1–like cytokine that signals via ST2, can reduce atherosclerosis development in ApoE−/− mice on a high-fat diet.
Miller, Ashley M., Xu, Damo, Asquith, Darren L., Denby, Laura, Li, Yubin, Sattar, Naveed, Baker, Andrew H., McInnes, Iain B., Liew, Foo Y.   +8 more
openaire   +3 more sources

A20 is a master switch of IL-33 signaling in macrophages and determines IL-33–induced lung immunity

Journal of Allergy and Clinical Immunology, 2023
IL-33 plays a major role in the pathogenesis of allergic diseases such as asthma and atopic dermatitis. On its release from lung epithelial cells, IL-33 primarily drives type 2 immune responses, accompanied by eosinophilia and robust production of IL-4, IL-5, and IL-13. However, several studies show that IL-33 can also drive a type 1 immune response.We
Aurora Holgado, Zhuangzhuang Liu, Aigerim Aidarova, Christina Mueller, Mira Haegman, Yasmine Driege, Marja Kreike, Charlotte L. Scott, Inna S. Afonina, Rudi Beyaert   +9 more
openaire   +3 more sources

IL‐33/ST2 as a potential target for tumor immunotherapy

European Journal of Immunology, 2021
IL‐33, a member of the IL‐1 family, was initially reported to be expressed constitutively in the nucleus of tissue‐lining and structural cells. However, upon tissue damage or injury, IL‐33 can be released quickly to bind with its cognate receptor ST2 in ...
Wenyi Jiang, Jingyao Lian, Ying Yue, Yi Zhang   +3 more
semanticscholar   +1 more source

Targeting IL-33 in Autoimmunity and Inflammation

The Journal of Pharmacology and Experimental Therapeutics, 2015
Interleukin-33 (IL-33) belongs to the IL-1 family of cytokines. Whereas IL-1 is processed and released by live immune cells in response to infection or other triggers, IL-33 is mostly released as a danger signal ("alarmin") from damaged cells. IL-33 may also be processed and released from activated mast cells (MCs) with subsequent autocrine and ...
Theoharides, Theoharis C., Petra, Anastasia I., Taracanova, Alexandra, Panagiotidou, Smaro, Conti, Pio   +4 more
openaire   +2 more sources

Interrelationship and Sequencing of Interleukins4, 13, 31, and 33 – An Integrated Systematic Review: Dermatological and Multidisciplinary Perspectives

Journal of Inflammation Research, 2022
Alin Laurentiu Tatu,1– 3,* Thomas Nadasdy,3,4 Anca Arbune,5,* Valentin Chioncel,6,* Carmen Bobeica,7 Elena Niculet,3,* Alina Viorica Iancu,7 Caterina Dumitru,8 Valentin Tudor Popa,3,9 Nicolas Kluger,10,11 Victor Gabriel Clatici,11 Claudiu
Tatu AL, Nadasdy T, Arbune A, Chioncel V, Bobeica C, Niculet E, Iancu AV, Dumitru C, Popa VT, Kluger N, Clatici VG, Vasile CI, Onisor C, Nechifor A   +13 more
doaj  

A Case-Control Study Indicates that no Association Exists Between Polymorphisms of IL-33 and IL-1RL1 and Preeclampsia

Cellular Physiology and Biochemistry, 2016
Background/Aims: Preeclampsia (PE) is a systemic inflammatory response syndrome involving varieties of cytokines, and previous studies have shown that IL-33 and its receptor IL-1RL1 play pivotal roles in the development of it. As a polygenetic hereditary
Xiaoyan Ren, Mingzhen Guo, Caili Liu, Tao Huang, Qiang Li, Mengmeng Han, Weiqing Song, Xiuming Tang, Shiguo Liu   +8 more
doaj   +1 more source

Expression of IL-21 and IL-33 in Intestinal Mucosa of Inflammatory Bowel Disease: An Immunohistochemical Study

Diagnostics, 2023
Interleukins are considered to be potential therapeutic targets that can alter the prognosis and disease progression of IBD. IL-21 has proven to be involved in effector Th1, Th2 and Th17 responses.
Alexandros Toskas, Stefanos Milias, Georgios Delis, Soultana Meditskou, Antonia Sioga, Theodora Papamitsou   +5 more
doaj   +1 more source

Evaluation of Serum IL-33, IL-5 and Trace Elements Levels among Asthmatic Patients

Journal of Pure and Applied Microbiology, 2022
The precise relationship between interleukins-33 and IL-5, as well as some trace elements and asthma, is unknown. The target of research was to compare and link the above-mentioned serological parameters in asthmatic patients and healthy controls.
Mayada Noori Iqbal, Sura O. Yosif, Jasim Mohammed Muhsin, Jaleel Samanje   +3 more
doaj   +1 more source