Results 51 to 60 of about 3,545,338 (242)
Single-Chain Soluble Receptor Fusion Proteins as Versatile Cytokine Inhibitors
Frontiers in Immunology, 2020 Cytokines are small secreted proteins that among many functions also play key roles in the orchestration of inflammation in host defense and disease.
Aurora Holgado +15 more
doaj +1 more source
PPARɣ drives IL-33-dependent ILC2 pro-tumoral functions
Nature Communications, 2021 Group 2 innate lymphoid cells (ILC2s) play a critical role in protection against helminths and in diverse inflammatory diseases by responding to soluble factors such as the alarmin IL-33, that is often overexpressed in cancer.
G. Ercolano +16 more
semanticscholar +1 more source
Cell Death and Disease, 2021 Atopic dermatitis (AD) is a common chronic pruritic inflammatory skin disorder characterized by recurrent eczematous lesions. Interleukin (IL)−33, a cytokine of the IL-1 family, was found to play an important role in the pathogenesis of AD.
Jie Zheng +7 more
semanticscholar +1 more source
IL-33 and IL-18 in Inflammatory Bowel Disease Etiology and Microbial Interactions
Frontiers in Immunology, 2019 The IL-1 cytokines are a newly expanded family, with each of its 11 members playing an important role in health and disease. Typically acting as pro- or anti-inflammatory mediators of first-line innate immunity, their production is particularly important
Michelle A. Williams +2 more
doaj +1 more source
Interleukin-31: A Pro-inflammatory Oriented Cytokine
Frontiers in Bioscience-LandmarkType 2 immunity is represented by T helper 2 (Th2) lymphocytes and the cytokines produced downstream (Interleukin (IL)-4, IL-13, IL-31). They are increasingly recognized as pivotal mediators in the pathogenesis of immune-mediated dermatological ...
Giuseppe Murdaca +3 more
doaj +1 more source
IL-33-activated ILC2s induce tertiary lymphoid structures in pancreatic cancer
NatureTertiary lymphoid structures (TLSs) are de novo ectopic lymphoid aggregates that regulate immunity in chronically inflamed tissues, including tumours. Although TLSs form due to inflammation-triggered activation of the lymphotoxin (LT)–LTβ receptor (LTβR)
M. Amisaki +35 more
semanticscholar +1 more source
Shedding light on IL-33 in the eye [PDF]
Journal of Experimental Medicine, 2016 ![Figure][1] Insight from Sachin Gadani (left) and Jonathan Kipnis (right) In this issue of JEM , [Xi et al.][2] describe how inflammation is initiated in the retina, studying the alarmin IL-33.
Gadani, Sachin P., Kipnis, Jonathan
openaire +2 more sources
IL-33/IL-31 Axis in Osteoporosis [PDF]
International Journal of Molecular Sciences, 2020 The study of the immunoskeletal interface has led to the discovery of numerous cytokines involved in the regulation of bone remodeling, providing valuable information on the pathogenesis of osteoporosis. The role of inflammatory cytokines of the Th1 and Th17 profile in osteoporosis is well known.
Massimo De Martinis +3 more
openaire +3 more sources
IL-33 Ameliorates the Development of MSU-Induced Inflammation Through Expanding MDSCs-Like Cells
Frontiers in Endocrinology, 2019 Interleukin-33 (IL-33), a member of the IL-1 superfamily, has been shown to play a critical role in many diseases through regulating the immune cell responses, including myeloid-derived suppressor cells (MDSCs). Our previous study demonstrated that IL-33
Ke Shang +9 more
doaj +1 more source
IL-33/ST2 axis in diverse diseases: regulatory mechanisms and therapeutic potential
Frontiers in ImmunologyInterleukin-33 (IL-33) is a nuclear factor and member of the IL-1 cytokine family. IL-33 is mainly expressed by epithelial and endothelial cells and exerts its function through interaction with various immune cells, and binding to its receptor can form ...
Feiya Sheng +6 more
semanticscholar +1 more source