Results 91 to 100 of about 6,663,297 (230)
Journal of the American Heart Association: Cardiovascular and Cerebrovascular DiseaseBackground Blockade of IL1RAP (interleukin 1 receptor associated protein) was recently shown to reduce atherosclerosis in mice, but the effect on human vascular cells is largely unknown.
Madelene Lindkvist +9 more
doaj +1 more source
Frontiers in Pharmacology, 2019 Obesity-linked (type 2) diabetic nephropathy (T2DN) has become the largest contributor to morbidity and mortality in the modern world. Recent evidences suggest that inflammation may contribute to the pathogenesis of T2DN and T-regulatory cells (Treg) are
Vikram Sabapathy +5 more
doaj +1 more source
Exogenous IL-33 induces Glrx and IL-33 in macrophages.
, 2019 RAW267.4 cells were stimulated by rIL-33 (10, 25 ng/ml) for 6 hrs after treatment with siCont or siGlrx. (A) Gene expression of IL-33, Glrx, and ST2L was assessed by RT-qPCR.
Beatriz Ferran (6264209) +6 more
core +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
Diversity and complexity in neural organoids
FEBS Letters, EarlyView.Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley +1 more source
Association of IL‐33 in modeling type‐2 airway inflammation and pulmonary emphysema in mice
Immunity, Inflammation and DiseaseWe developed pulmonary emphysema and a type 2 airway inflammation overlap mouse model. The bronchoalveolar lavage (BAL) interleukin 13 (IL‐13), IL‐4, and IL‐5 levels in the overlap model were higher than in the pulmonary emphysema model and lower than in
Chika Miyaoka +11 more
doaj +1 more source
FEBS Letters, EarlyView.Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley +1 more source
Objective:Identify key features of IL-33 immunobiology important in allergic and nonallergic airway inflammatory diseases and potential therapeutic strategies to reduce disease burden.Data Sources:PubMed, clinicaltrials.govStudy Selections:A systematic ...
core
IL-33 is expressed in normal lung tissue.
, 2018 Representative images of immunohistochemistry staining analysis of IL-33 (brown) expression in human lung tissues. (A) bronchial epithelial cells, (B) chondrocytes, (C) vascular endothelial cell (D) alveolus and glandular cells.
Yuehua Feng (619696) +7 more
core +1 more source