Astrocyte-secreted IL-33 mediates homeostatic synaptic plasticity in the adult hippocampus
Proceedings of the National Academy of Sciences of the United States of America, 2020 Significance Synaptic plasticity in the hippocampus is important for learning and memory formation. In particular, homeostatic synaptic plasticity enables neurons to restore their activity levels in response to chronic neuronal activity changes.
Ye Wang +9 more
semanticscholar +1 more source
Group 2 innate lymphoid cells contribute to IL-33-mediated alleviation of cardiac fibrosis
Theranostics, 2021 Rationale: The major cause of heart failure is myocardium death consequent to detrimental cardiac remodeling and fibrosis following myocardial infarction.
Wei‐Yu Chen +7 more
semanticscholar +1 more source
Association Between Helicobacter pylori cagA, babA2 Virulence Factors and Gastric Mucosal Interleukin-33 mRNA Expression and Clinical Outcomes in Dyspeptic Patients [PDF]
, 2015 Helicobacter pylori (H. pylori) infection has been reported in more than half of the world human population. It is associated with gastric inflammation and noticeable infiltration of the immune cells to the stomach mucosa by several cytokines secretion ...
Bagheri, Nader. +5 more
core +3 more sources
IL-1 Family Cytokine Regulation of Vascular Permeability and Angiogenesis
Frontiers in Immunology, 2019 The IL-1 family of cytokines are well-known for their primary role in initiating inflammatory responses both in response to and acting as danger signals.
Erin Fahey +4 more
doaj +1 more source
Intravenously delivered graphene nanosheets and multiwalled carbon nanotubes induce site-specific Th2 inflammatory responses via the IL-33/ST2 axis [PDF]
, 2013 Carbon-based nanomaterials (CBN), such as graphene nanosheets (GNS) and multiwalled carbon nanotubes (MWCNT), have been proposed for potential nanomedicine applications such as biomedical devices and carriers for drug delivery.
Brown, Jared M +5 more
core +3 more sources
Cellular context of IL-33 expression dictates impact on anti-helminth immunity
Science immunology, 2020 The pore-forming protein perforin-2 facilitates IL-33 release from dendritic cells. IL-33 and roundworm clearance Immune control of helminth infections is achieved via type 2 immune responses involving group 2 innate lymphoid cells (ILC2), with the ...
Li-Yin Hung +18 more
semanticscholar +1 more source
IL-33 Deals with the Gray Matter [PDF]
Immunity, 2018 The central nervous system undergoes extensive postnatal synapse remodeling that is critical for the formation of mature neural circuits. In a recent issue of Science, Vainchtein et al. (2018) describe an additional role for astrocyte-derived interleukin-33 (IL-33) in promoting synapse refinement by microglia in the developing brain.
Charlène, Delmas, Elise, Dalmas
openaire +2 more sources
Prevalence and Trajectory of Household Material Hardship Among Children With Advanced Cancer
Pediatric Blood &Cancer, EarlyView.ABSTRACT Background/Objectives Families of children with advanced cancer living in poverty experience inferior outcomes including poor parent mental health and worse child quality of life. Household material hardship (HMH: food, housing, transportation, and/or utility insecurity) is a modifiable poverty exposure—and potential intervention target—that ...
Sarah Wright +13 more
wiley +1 more source
IL-33/ST2 induces neutrophil-dependent reactive oxygen species production and mediates gout pain
Theranostics, 2020 Objective: Gout, induced by monosodium urate (MSU) crystal deposition in joint tissues, provokes severe pain and impacts life quality of patients. However, the mechanisms underlying gout pain are still incompletely understood.
Chengyu Yin +14 more
semanticscholar +1 more source
IL-33/ST2 Axis in Organ Fibrosis [PDF]
Frontiers in Immunology, 2018 Interleukin 33 (IL-33) is highly expressed in barrier sites, acting via the suppression of tumorigenicity 2 receptor (ST2). IL-33/ST2 axis has long been known to play a pivotal role in immunity and cell homeostasis by promoting wound healing and tissue repair. However, it is also involved in the loss of balance between extensive inflammation and tissue
Ourania S. Kotsiou +4 more
openaire +3 more sources