Results 111 to 120 of about 67,088,256 (273)

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

FEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source

Association of IL‐33 in modeling type‐2 airway inflammation and pulmonary emphysema in mice

Immunity, Inflammation and Disease
We developed pulmonary emphysema and a type 2 airway inflammation overlap mouse model. The bronchoalveolar lavage (BAL) interleukin 13 (IL‐13), IL‐4, and IL‐5 levels in the overlap model were higher than in the pulmonary emphysema model and lower than in
Chika Miyaoka, Masato Watanabe, Keitaro Nakamoto, Yuki Yoshida, Aya Hirata, Jumpei Aso, Hiroki Nunokawa, Manabu Ishida, Koujiro Honda, Saori Takata, Takeshi Saraya, Haruyuki Ishii   +11 more
doaj   +1 more source

Biophysical approaches for studying viral entry

FEBS Letters, EarlyView.
Viruses infect all living organisms and have been responsible for major epidemics and pandemics. Their ongoing evolutionary battle with host defenses creates a constant need for improved tools to study viral behavior. Advancing methods to probe viral attachment, fusion, and genome release deepen our understanding of how infections begin and support the
Inbar Yosibash, Raya Sorkin
wiley   +1 more source

Factors associated with plasma IL-33 levels in patients with chronic obstructive pulmonary disease

, 2017
Sei Won Kim,1,* Chin Kook Rhee,2,* Ki Uk Kim,3 Sang Haak Lee,4 Hun Gyu Hwang,5 Yu Il Kim,6 Deog Kyeom Kim,7 Sang Do Lee,8 Yeon-Mok Oh,8 Hyoung Kyu Yoon1 On behalf of the KOLD Study Group 1Division of Pulmonary, Department of Internal Medicine, Yeouido ...
Kim SW, Oh YM, Kim YI, Rhee CK, Lee SH, Hwang HG, Lee SD, Kim DK, Yoon HK, Kim KU   +9 more
core  

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

ST2 and IL-33 in Pregnancy and Pre-Eclampsia

PLoS ONE, 2011
Normal pregnancy is associated with a mild systemic inflammatory response and an immune bias towards type 2 cytokine production, whereas pre-eclampsia is characterized by a more intense inflammatory response, associated with endothelial dysfunction and a type 1 cytokine dominance.
Granne, I, Southcombe, J, Snider, J, Tannetta, D, Child, T, Redman, C, Sargent, I   +6 more
openaire   +6 more sources

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

IL-33 potentiates histaminergic itch

Journal of Allergy and Clinical Immunology
Itch is a common symptom that can greatly diminish quality of life. Histamine is a potent endogenous pruritogen, and while antihistamines are often the first-line treatment for itch, in conditions like chronic spontaneous urticaria (CSU), many patients remain symptomatic while receiving maximal doses.
Anna M. Trier, Aaron M. Ver Heul, Avery Fredman, Victoria Le, Zhen Wang, Kelsey Auyeung, James Meixiong, Paola Lovato, Michael J. Holtzman, Fang Wang, Xinzhong Dong, Andrew L. Ji, Brian S. Kim   +12 more
openaire   +3 more sources

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

TL1A is an epithelial alarmin that cooperates with IL-33 for initiation of allergic airway inflammation

International audienceEpithelium-derived cytokines or alarmins, such as interleukin-33 (IL-33) and thymic stromal lymphopoietin (TSLP), are major players in type 2 immunity and asthma.
Schmitt, Pauline, Bellard, Elisabeth, Camus, Mylène, Burlet-Schiltz, Odile, Girard, Jean-Philippe, Duval, Anais, Cayrol, Corinne, Dedieu, Cécile, Roga, Stéphane, Gonzalez-De-Peredo, Anne, Lefrançais, Emma, Mouton-Barbosa, Emmanuelle, Ortega, Nathalie, Mirey, Emilie   +13 more
core   +1 more source