Results 141 to 150 of about 4,627,366 (384)

Novel Immunomodulatory Cytokine Regulates Inflammation, Diabetes, and Obesity to Protect From Diabetic Nephropathy

Frontiers in Pharmacology, 2019
Obesity-linked (type 2) diabetic nephropathy (T2DN) has become the largest contributor to morbidity and mortality in the modern world. Recent evidences suggest that inflammation may contribute to the pathogenesis of T2DN and T-regulatory cells (Treg) are
Vikram Sabapathy, Marta E. Stremska, Saleh Mohammad, Rebecca L. Corey, Poonam R. Sharma, Rahul Sharma   +5 more
doaj   +1 more source

Eosinophils, their progenitors and T helper cells in allergic airway inflammation [PDF]

, 2011
Introduction: Asthma is a heterogeneous chronic lung disease associated with pronounced inflammatory changes in the airways. Eosinophilic inflammation is the trait that is best linked to symptoms and treatment responses in allergic asthma.
Lu, You
core   +1 more source

Two Faces of NOTCH1 in Childhood Lymphoblastic T‐Cell Neoplasia: Prognostic Divergence of Mutational and Structural Aberrations

Pediatric Blood &Cancer, EarlyView.
ABSTRACT In pediatric patients, T‐cell lymphoblastic lymphoma (T‐LBL) survival exceeds 80%. Relapse remains associated with limited curative options. Frontline treatment is largely extrapolated from T‐cell acute lymphoblastic leukemia (T‐ALL) treatment, reflecting the ongoing debate, whether both entities represent distinct diseases or variants within ...
Marie C. Heider, Amelie Alfert, Marc Hotfilder, Birgit Burkardt, Marcel te Vrugt   +4 more
wiley   +1 more source

Sexual maturation protects against development of lung inflammation through estrogen. [PDF]

, 2016
Increasing levels of estrogen and progesterone are suggested to play a role in the gender switch in asthma prevalence during puberty. We investigated whether the process of sexual maturation in mice affects the development of lung inflammation in ...
Boorsma, Carian E, Draijer, Christina, Greene, Catherine M, Hylkema, Machteld N, Klok, Pieter A, Melgert, Barbro N, Postma, Dirkje S, Robbe, Patricia, Timens, Wim   +8 more
core   +1 more source

Ethnic Differences in the Association Between SOD2 rs4880 and Hepatotoxicity in Pediatric Acute Lymphoblastic Leukemia: A Report From the REDIAL Consortium

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Treatment‐associated hepatotoxicity (TAH) is a common complication of pediatric acute lymphoblastic leukemia (ALL) treatment, but genetic risk factors remain poorly understood. We evaluated the SOD2 rs4880 variant in 544 children with ALL at Texas Children's Hospital. After adjusting for demographic and clinical covariates, the rs4880 C allele
Emily J. Mason, John P. Woodhouse, Joanna S. Yi, M. Monica Gramatges, Olga A. Taylor, Veronica A. Morales, Shalini Dhamodharan, Marley Roberts, Karen R. Rabin, Philip J. Lupo, Michael E. Scheurer, Van Huynh, Steven D. Mittelman, Etan Orgel, Austin L. Brown   +14 more
wiley   +1 more source

IL-33 and IL-3 synergistically induce CD25 expression on human basophils without functional IL-2 signaling: a potential marker of severe COVID-19

Frontiers in Immunology
CD25 (IL-2 receptor alpha chain) is a key component of the high-affinity receptor for the IL-2 cytokine and regulates the proliferation, survival, and differentiation of immune cells.
Sruthi Vijaya Retnakumar, Suraj Chandrabhan Singh, Camille Chauvin, Jagadeesh Bayry, Jagadeesh Bayry   +4 more
doaj   +1 more source

Detrimental role of IL-33/ST2 pathway sustaining a chronic eosinophil-dependent Th2 inflammatory response, tissue damage and parasite burden during Toxocara canis infection in mice

, 2021
Thaís Leal-Silva, Flaviane Vieira-Santos, Luiza de Lima Silva Padrão, Lucas Kraemer Rocha, Pablo Hemanoel da Paixão Matias, Camila de Almeida Lopes, Ana Cristina Loiola Ruas, Isabella Carvalho De Azevedo, Denise Silva Nogueira, Milene Alvarenga Rachid, Marcelo Vidigal Caliari, Remo Castro Russo, Lilian Lacerda Bueno, Fabrício Marcus Silva Oliveira, Ricardo Toshio Fujiwara   +14 more
openalex   +1 more source

HpARI protein secreted by a helminth parasite suppresses interleukin-33 [PDF]

, 2017
Infection by helminth parasites is associated with amelioration of allergic reactivity, but mechanistic insights into this association are lacking.
Alasdair C. Ivens, Andrea Gonzàlez-Cìscar, Andrea M. Kemter, Anne L. Astier, Baker, Bartemes, Berman, Bessa, Blein, Buck, Bønnelykke, Bønnelykke, Castanhinha, Cayrol, Chen, Christianson, Claire Errington, Coakley, Cohen, Danielle J. Smyth, de Castro, De Salvo, Dennis Hoving, Dinesh C. Soares, E. Suzanne Cohen, Francesco Vacca, Gautier, Henry J. McSorley, Hewitson, Hewitson, Holly Henderson, Howe, Hristova, Hung, Ian C. Scott, Jackson, James P. Hewitson, Johnston, Jordan, Jürgen Schwarze, Kara J. Filbey, Kirkitadze, Kouzaki, Lawrence, Leffler, Lefrançais, Lefrançais, Lefrançais, Letunic, Liew, Lovell, Maizels, Maizels, Makou, Martin Wear, Matilda Toivakka, McSorley, McSorley, McSorley, Megan Osbourn, Moffatt, Morgan, Neill, Prota, Rick M. Maizels, Robert, Saglani, Sali, Saravia, Schiering, Shen, Shimokawa, Simon, Sjöberg, Soares, Soares, Sonja Vermeren, Söding, Thierry le Bihan, Thompson, Tordesillas, Trouw, William A. Wallace, William F. Gregory, Yang   +84 more
core   +7 more sources

Assessing Cognitive Functioning in Children With Brain Tumors: Interaction of Neighborhood Social Determinants of Health and Neurological Risk

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background This study investigated how neighborhood‐level social determinants of health (SDOH), including redlining and neurological risk, interact to influence cognitive outcomes in children treated for brain tumors (CTBT). Methods A retrospective chart review of 161 CTBT aged 5–17 was conducted.
Alannah R. Srsich, Manali Zope, Peter M. Fantozzi, Cassie N. Kline, Iris Paltin, Matthew C. Hocking   +5 more
wiley   +1 more source

IL1RAP Expression in Human Atherosclerosis: A Target of Novel Antibodies to Reduce Vascular Inflammation and Adhesion

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Background Blockade of IL1RAP (interleukin 1 receptor associated protein) was recently shown to reduce atherosclerosis in mice, but the effect on human vascular cells is largely unknown.
Madelene Lindkvist, Anna Göthlin Eremo, Geena Varghese Paramel, Sheikh Anisul Haque, Camilla Rydberg Millrud, Sara Rattik, Caitríona Grönberg, David Liberg, Allan Sirsjö, Karin Fransén   +9 more
doaj   +1 more source