Mapping the evolution of mitochondrial complex I through structural variation
FEBS Letters, EarlyView.Respiratory complex I (CI) is crucial for bioenergetic metabolism in many prokaryotes and eukaryotes. It is composed of a conserved set of core subunits and additional accessory subunits that vary depending on the organism. Here, we categorize CI subunits from available structures to map the evolution of CI across eukaryotes. Respiratory complex I (CI)
Dong‐Woo Shin +2 more
wiley +1 more source
Group 2 innate lymphoid cells exhibit a dynamic phenotype in allergic airway inflammation [PDF]
, 2017 Group 2 innate lymphoid cells (ILC2) are implicated in allergic asthma as an early innate source of the type 2 cytokines IL-5 and IL-13. However, their induction in house dust mite (HDM)-mediated airway inflammation additionally requires T cell ...
Beerens, D.M.J.M. (Dior) +13 more
core +1 more source
IL-33/IL-31 Axis in Immune-Mediated and Allergic Diseases
International Journal of Molecular Sciences, 2019 Several allergic and immunologic diseases including asthma, food allergy (FA), chronic spontaneous urticaria (CSU), atopic dermatitis (AD), systemic lupus erythematosus (SLE), systemic sclerosis (SSc), rheumatoid arthritis (RA), and Behçet’s disease (BD)
G. Murdaca +6 more
semanticscholar +1 more source
Organoids in pediatric cancer research
FEBS Letters, EarlyView.Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley +1 more source
IL-33 Induces Cytokine Production By Lineage-Committed Myeloid Progenitors and Positively Regulates Eosinophil Hematopoiesis in IL-5-Dependent Manner [PDF]
, 2015 Hirofumi Tsuzuki +13 more
openalex +1 more source
An intrinsic role of IL-33 in Treg cell-mediated tumor immunoevasion
Nature Immunology, 2019 Regulatory T (Treg) cells accumulate into tumors, hindering the success of cancer immunotherapy. Yet, therapeutic targeting of Treg cells shows limited efficacy or leads to autoimmunity.
A. Hatzioannou +17 more
semanticscholar +1 more source
Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?
FEBS Letters, EarlyView.This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes +3 more
wiley +1 more source
INFLAMMASOME NLRP1 DISTINCTIVE FEATURES IN ATOPIC CONDITIONS
Медицина в Кузбассе, 2023 The review article focuses on the NLRP1 inflammasome, which was discovered before the others but has been the least investigated. The emergence of the inflammasome in innate immunity container cells is an early event that precedes the development of any ...
Денис Сергеевич Загрешенко +5 more
doaj
Research Progress of IL-33/ST2 Signaling Pathway in Cardiovascular Disease [PDF]
, 2018 Yang Wang, Bin Wang
openalex +1 more source
Elevated Levels of IL-33, IL-17 and IL-25 Indicate the Progression from Chronicity to Hepatocellular Carcinoma in Hepatitis C Virus Patients [PDF]
, 2022 Momen Askoura +9 more
openalex +1 more source