Results 181 to 190 of about 4,627,366 (384)

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

IL-33/IL-31 Axis: A Potential Inflammatory Pathway

Mediators of Inflammation, 2018
Cytokines play an important role in the regulation of the immune system (adaptive and innate). Given their importance in proinflammatory processes, cytokines have been used for understanding the pathogenesis and as biomarkers in many diseases.
Eleonora Di Salvo, Elvira Ventura-Spagnolo, Marco Casciaro, Michele Navarra, Sebastiano Gangemi   +4 more
doaj   +1 more source

IL-33 modulates inflammatory brain injury but exacerbates systemic immunosuppression following ischemic stroke [PDF]

, 2018
Shenpeng R. Zhang, Marius Piepke, Hannah X. Chu, Brad R. S. Broughton, Raymond Shim, Connie H. Y. Wong, Seyoung Lee, Megan A. Evans, Antony Vinh, Samy Sakkal, Thiruma V. Arumugam, Tim Magnus, Samuel Huber, Mathias Gelderblom, Grant R. Drummond, Christopher G. Sobey, Hyun Ah Kim   +16 more
openalex   +1 more source

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

Hypo-osmotic Stress Drives IL-33 Production in Human Keratinocytes—An Epidermal Homeostatic Response [PDF]

, 2018
Wojciech Pietka, Denis Khnykin, Vibeke Bertelsen, Astrid Haaskjold Lossius, Tor Espen Stav-Noraas, Johanna Hol Fosse, Hilde Kanli Galtung, Guttorm Haraldsen, Olav Sundnes   +8 more
openalex   +1 more source

L'interleukine-33, cytokine de la famille IL-1 : régulation par les protéases inflammatoires [PDF]

, 2012
L'interleukine-33 (IL-33) est le dernier membre identifié de la famille des cytokines IL-1. L'intérêt qui lui est porté est grandissant, notamment depuis la découverte de ses cellules cibles majeures, les cellules lymphoïdes innées de type 2 (ILC2 ...
Lefrançais, Emma
core  

Behçet hastalığında serum IL-33 düzeyi ve IL-33 gen polimorfizmleri

, 2020
Tekrarlayıcı mukokutanöz, oküler, kas-iskelet, gastrointestinal ve santral sinir sistem tutulumları ile karakterize, inflamatuar bir hastalık olan Behçet hastalığı (BH), ülkemizin de içinde bulunduğu bazı coğrafik alanlarda sık görülmektedir. Etiyopatogenezi tam olarak aydınlatılamamış olsa da immün aktivasyon, IL-1ß düzeyinde artış ve IL-1 gen ...
openaire   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

FEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes, Jan Brysch, Carmen Gelze, Lilli Meier, Daniel Kümmel   +4 more
wiley   +1 more source

CREB regulates Foxp3+ST-2+ TREGS with enhanced IL-10 production

Frontiers in Immunology
IntroductionRegulatory T-cells (Tregs) are characterized by the expression of Foxp3, a master regulator involved in the development and function of Tregs.
Sudheendra Hebbar Subramanyam, Judit Turyne Hriczko, Saskia Schulz, Thomas Look, Thomas Look, Tannaz Goodarzi, Tim Clarner, Miriam Scheld, Markus Kipp, Eva Verjans, Svenja Böll, Christopher Neullens, Ivan Costa, Zhijian Li, Lin Gan, Bernd Denecke, Angela Schippers, Stefan Floess, Jochen Huehn, Edgar Schmitt, Tobias Bopp, Hermann Wasmuth, Ron Winograd, Rudi Beyaert, Rudi Beyaert, Bart Lambrecht, Bart Lambrecht, Martin Zenke, Martin Zenke, Martin Zenke, Martin Zenke, Norbert Wagner, Kim Ohl, Klaus Tenbrock, Klaus Tenbrock   +34 more
doaj   +1 more source