Results 261 to 270 of about 1,087,614 (283)

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

Molecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli, Alessio Bevilacqua, Mathias Wenes, Denis Migliorini, Lars van der Veen, Sigrid S Skånland, Giusy Di Conza, Kjetil Taskén   +7 more
wiley   +1 more source

IL-33 Participates in <i>G. Vaginalis</i>-Induced Bacterial Vaginosis: Involvement of Intravaginal IgA. [PDF]

J Inflamm Res
Zhou M, Zhou L, Liu J, Yu S.
europepmc   +1 more source

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

Molecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta, Yang Song, Madeleine Ndahayo, Anirudh Saxena, Theresa Guo, Dylan Z. Kelley, Jessica Gore, Andrew Hennigan, Alexa Anderson, John C. Papadimitriou, Daria A. Gaykalova   +10 more
wiley   +1 more source

The clinicopathological implications of serum IL-33 and sST2 as cancer biomarkers: A narrative review. [PDF]

J Oral Biol Craniofac Res
Acharya S, Hegde U, Acharya AB.
europepmc   +1 more source

IL-33-primed NLRP3 inflammasome in basophils drives IL-1β production and initiates atopic dermatitis inflammation. [PDF]

Cell Death Discov
Gunji Y, Matsumura T, Karasawa T, Komada T, Baatarjav C, Komori S, Aizawa H, Mizushina Y, Tsuda H, Miyake K, Maruyama T, Ohmori T, Karasuyama H, Takahashi M.   +13 more
europepmc   +1 more source

Etoposide activates CD8⁺ T cell anti-tumor immunity in osteosarcoma through MHC I upregulation via tumor-secreted IL-33 mediated signaling. [PDF]

J Immunother Cancer
He X, Li H, Wang H, Zuo D, Dong H, Mu H, Yang B, Tao Y, Yang X, Zhao B, Zhang T, Jiang Y, Wang Z, Wang H, Yang L, Hua Y, Cai Z, Wang C, Sun M, Gui J, Sun W.   +20 more
europepmc   +1 more source

Enhanced Alarmin Secretion Exacerbates Neutrophil Extracellular Trap (NET) Formation in Active Psoriasis: Implication of IL-33 and TSLP in Driving NET Formation, Inflammation and Oxidative Stress in Psoriasis. [PDF]

Antioxidants (Basel)
Ojha V, Tembhre MK, Gupta V.
europepmc   +1 more source

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Thrombin cleaves IL‐33 and modulates IL‐33‐activated allergic lung inflammation

Allergy, 2022
AbstractBackgroundOrganisms have orchestrated coagulation and immune systems. Although a link between inflammation and haemostasis has been reported in asthma, the interaction mechanism has not been completely elucidated. Here, we investigated the direct link between the mammalian immune and coagulation systems.MethodsMice were administered protease or
Yuying Huang, Xuezhen Li, Lin Zhu, Chunrong Huang, Wen Chen, Zhiyang Ling, SongLing Zhu, Xintong Feng, Chunyan Yi, Wangpeng Gu, Chenghua Yan, Jing Wang, Liyan Ma, Xiao Su, Ranran Dai, Guochao Shi, Bing Sun, Yaguang Zhang   +17 more
openaire   +2 more sources

The Reparative Roles of IL-33

Transplantation, 2023
When discovered in the early 2000s, interleukin-33 (IL-33) was characterized as a potent driver of type 2 immunity and implicated in parasite clearance, as well as asthma, allergy, and lung fibrosis. Yet research in other models has since revealed that IL-33 is a highly pleiotropic molecule with diverse functions.
Johnny, Bou Saba, Hēth R, Turnquist
openaire   +2 more sources

Cystic Fibrosis Reprograms Airway Epithelial IL-33 Release and Licenses IL-33–Dependent Inflammation

American Journal of Respiratory and Critical Care Medicine, 2023
Rationale: Type 2 inflammation has been described in people with cystic fibrosis (CF). Whether loss of CFTR (cystic fibrosis transmembrane conductance regulator) function contributes directly to a type 2 inflammatory response has not been fully defined. Objectives: The potent alarmin IL-33 has emerged as a critical regulator of type 2 inflammation.
Daniel P. Cook, Christopher M. Thomas, Ashley Y. Wu, Mark Rusznak, Jian Zhang, Weisong Zhou, Jacqueline-Yvonne Cephus, Katherine N. Gibson-Corley, Vasiliy V. Polosukhin, Allison E. Norlander, Dawn C. Newcomb, David A. Stoltz, R. Stokes Peebles   +12 more
openaire   +2 more sources