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Thrombin cleaves IL‐33 and modulates IL‐33‐activated allergic lung inflammation
Allergy, 2022AbstractBackgroundOrganisms have orchestrated coagulation and immune systems. Although a link between inflammation and haemostasis has been reported in asthma, the interaction mechanism has not been completely elucidated. Here, we investigated the direct link between the mammalian immune and coagulation systems.MethodsMice were administered protease or
Yuying Huang +17 more
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Transplantation, 2023
When discovered in the early 2000s, interleukin-33 (IL-33) was characterized as a potent driver of type 2 immunity and implicated in parasite clearance, as well as asthma, allergy, and lung fibrosis. Yet research in other models has since revealed that IL-33 is a highly pleiotropic molecule with diverse functions.
Johnny, Bou Saba, Hēth R, Turnquist
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When discovered in the early 2000s, interleukin-33 (IL-33) was characterized as a potent driver of type 2 immunity and implicated in parasite clearance, as well as asthma, allergy, and lung fibrosis. Yet research in other models has since revealed that IL-33 is a highly pleiotropic molecule with diverse functions.
Johnny, Bou Saba, Hēth R, Turnquist
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Cystic Fibrosis Reprograms Airway Epithelial IL-33 Release and Licenses IL-33–Dependent Inflammation
American Journal of Respiratory and Critical Care Medicine, 2023Rationale: Type 2 inflammation has been described in people with cystic fibrosis (CF). Whether loss of CFTR (cystic fibrosis transmembrane conductance regulator) function contributes directly to a type 2 inflammatory response has not been fully defined. Objectives: The potent alarmin IL-33 has emerged as a critical regulator of type 2 inflammation.
Daniel P. Cook +12 more
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IL-33/ST2 axis in autoimmune disease
Cytokine, 2022Interleukin-33 (IL-33) is a member of the IL-1 family and plays an ambivalent role in autoimmune diseases. IL-33 signals via the ST2 receptor and drives cytokine production in mast cells, basophils, eosinophils, NK cells, and T lymphocyte cells. The vital role of IL-33 as an active component gives rise to aberrant local and systemic damage which has ...
Leila Shakerian +7 more
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Development of an interleukin (IL)-33 sandwich ELISA kit specific for mature IL-33
Journal of Immunoassay and Immunochemistry, 2016Interleukin (IL)-33 is an inflammatory cytokine and belongs to the IL-1 family of cytokines. There are eleven members of the IL-1 family of cytokines and all have important roles in host defense against infections. Their levels are increased during infection and in various auto-inflammatory diseases.
Eunsom, Kim +10 more
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Anti-fungal effect of IL-33: Regulation of neutrophil activities by IL-33
2012 7th International Forum on Strategic Technology (IFOST), 2012IL-33 is known to play an important role in Th2 immunity. In this study, we investigated the effect of IL-33 pretreatment on anti-fungal response using an acute Candida albicans peritoneal infection model. IL-33 pre-treatment induced a rapid fungal clearance and markedly reduced the C. albicans infection-associated mortality.
Hong Rae Cho, Byungsuk Kwon
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Targeting IL-33 in Autoimmunity and Inflammation
The Journal of Pharmacology and Experimental Therapeutics, 2015Interleukin-33 (IL-33) belongs to the IL-1 family of cytokines. Whereas IL-1 is processed and released by live immune cells in response to infection or other triggers, IL-33 is mostly released as a danger signal ("alarmin") from damaged cells. IL-33 may also be processed and released from activated mast cells (MCs) with subsequent autocrine and ...
Theoharis C, Theoharides +4 more
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Stromal IL-33 balances fat stores
Nature Reviews Immunology, 2019Two new studies identify the discrete stromal cell subtypes that produce IL-33 in adipose tissue to support the immune cells that maintain adipose tissue homeostasis.
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Role of IL-33 in transplant biology
European Cytokine Network, 2019Since the pro-inflammatory cytokine IL-33 and its receptor (ST2) are closely involved in regulating both innate and adaptive immune responses, it is conceivable that they may play an important role in organ transplantation. IL-33 is broadly expressed by multiple cell types such as fibroblasts, epithelial cells, and endothelial cells.
Ying, Jin +3 more
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Science's STKE, 2007
Interleukin-33 (IL-33), a member of the IL-1 family of cytokines, mediates its effects through a heterodimer consisting of ST2L and an as-yet-unidentified second receptor. IL-33 stimulates the production of cytokines associated with a T helper 2 (Th2) response, including IL-5 and IL-13.
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Interleukin-33 (IL-33), a member of the IL-1 family of cytokines, mediates its effects through a heterodimer consisting of ST2L and an as-yet-unidentified second receptor. IL-33 stimulates the production of cytokines associated with a T helper 2 (Th2) response, including IL-5 and IL-13.
openaire +1 more source