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IL-33/ST2 axis in autoimmune disease
Cytokine, 2022Interleukin-33 (IL-33) is a member of the IL-1 family and plays an ambivalent role in autoimmune diseases. IL-33 signals via the ST2 receptor and drives cytokine production in mast cells, basophils, eosinophils, NK cells, and T lymphocyte cells. The vital role of IL-33 as an active component gives rise to aberrant local and systemic damage which has ...
Leila Shakerian +7 more
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Development of an interleukin (IL)-33 sandwich ELISA kit specific for mature IL-33
Journal of Immunoassay and Immunochemistry, 2016Interleukin (IL)-33 is an inflammatory cytokine and belongs to the IL-1 family of cytokines. There are eleven members of the IL-1 family of cytokines and all have important roles in host defense against infections. Their levels are increased during infection and in various auto-inflammatory diseases.
Eunsom, Kim +10 more
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Anti-fungal effect of IL-33: Regulation of neutrophil activities by IL-33
2012 7th International Forum on Strategic Technology (IFOST), 2012IL-33 is known to play an important role in Th2 immunity. In this study, we investigated the effect of IL-33 pretreatment on anti-fungal response using an acute Candida albicans peritoneal infection model. IL-33 pre-treatment induced a rapid fungal clearance and markedly reduced the C. albicans infection-associated mortality.
Hong Rae Cho, Byungsuk Kwon
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Targeting IL-33 in Autoimmunity and Inflammation
The Journal of Pharmacology and Experimental Therapeutics, 2015Interleukin-33 (IL-33) belongs to the IL-1 family of cytokines. Whereas IL-1 is processed and released by live immune cells in response to infection or other triggers, IL-33 is mostly released as a danger signal ("alarmin") from damaged cells. IL-33 may also be processed and released from activated mast cells (MCs) with subsequent autocrine and ...
Theoharis C, Theoharides +4 more
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Stromal IL-33 balances fat stores
Nature Reviews Immunology, 2019Two new studies identify the discrete stromal cell subtypes that produce IL-33 in adipose tissue to support the immune cells that maintain adipose tissue homeostasis.
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Role of IL-33 in transplant biology
European Cytokine Network, 2019Since the pro-inflammatory cytokine IL-33 and its receptor (ST2) are closely involved in regulating both innate and adaptive immune responses, it is conceivable that they may play an important role in organ transplantation. IL-33 is broadly expressed by multiple cell types such as fibroblasts, epithelial cells, and endothelial cells.
Ying, Jin +3 more
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Science's STKE, 2007
Interleukin-33 (IL-33), a member of the IL-1 family of cytokines, mediates its effects through a heterodimer consisting of ST2L and an as-yet-unidentified second receptor. IL-33 stimulates the production of cytokines associated with a T helper 2 (Th2) response, including IL-5 and IL-13.
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Interleukin-33 (IL-33), a member of the IL-1 family of cytokines, mediates its effects through a heterodimer consisting of ST2L and an as-yet-unidentified second receptor. IL-33 stimulates the production of cytokines associated with a T helper 2 (Th2) response, including IL-5 and IL-13.
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IL-33 meets allergens at the gate
Nature Immunology, 2018IL-33 is a mediator of allergic inflammation and is localized in mucosal tissues to respond rapidly to environmental insults. These include allergens themselves, which can directly activate IL-33 through their intrinsic proteolytic activity.
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IL-33 Enhances Histaminergic Itch
Journal of Allergy and Clinical Immunology, 2022Anna Trier +6 more
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