Results 101 to 110 of about 1,206,376 (271)

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

Emerging cytokines contribute to the clinical manifestation of carotid artery plaque formation and stability in patients with diabetes

Atherosclerosis Plus
Background: Type 2 diabetes mellitus (T2DM) promotes atherosclerosis and plaque instability through chronic inflammation and immune dysregulation. Emerging evidence implicates members of the interleukin-1 family—particularly IL-36, IL-37, and IL-38—in ...
Zhongqing Xu, James Healy, Wenhui Dong, JingJing Ding, Xiaoyi Shen, Xianzhen Feng, Jun Zhou, Rajesh Puranik, Brett D. Hambly, Shisan Bao   +9 more
doaj   +1 more source

Interleukin-37 Inhibits Colon Carcinogensis During Chronic Colitis

Frontiers in Immunology, 2019
Inflammatory bowel disease increases the risk of developing colon cancer. Interleukin (IL-) 37 is a fundamental inhibitor of innate immunity by reducing systemic and local inflammation.
Steffeni Mountford, Andrea Ringleb, Rahel Schwaiger, Doris Mayr, Sebastian Kobold, Sebastian Kobold, Charles A. Dinarello, Philip Bufler, Philip Bufler   +8 more
doaj   +1 more source

An intracellular transporter mitigates the CO2‐induced decline in iron content in Arabidopsis shoots

FEBS Letters, EarlyView.
This study identifies a gene encoding a transmembrane protein, MIC, which contributes to the reduction of shoot Fe content observed in plants under elevated CO2. MIC is a putative Fe transporter localized to the Golgi and endosomal compartments. Its post‐translational regulation in roots may represent a potential target for improving plant nutrition ...
Timothy Mozzanino, Meijie Li, Cécile Fizames, Mattia Adamo, Laurence Lejay, Christian Dubos, Matthieu Platre, Antoine Martin   +7 more
wiley   +1 more source

Modelling of Multi-Agent Systems: Experiences with Membrane Computing and Future Challenges

, 2010
Formal modelling of Multi-Agent Systems (MAS) is a challenging task due to high complexity, interaction, parallelism and continuous change of roles and organisation between agents.
C. Martin-Vide, C. Rouf, D. Corne, D. Jackson, E. A. Emerson, E. Kapeti, F. Bernardini, F. Ipate, F. Ipate, G. Ciobanu, G. Pu aun, G.J. Holzmann, I. Stamatopoulou, I. Stamatopoulou, I. Stamatopoulou, I. Stamatopoulou, I. Stamatopoulou, I. Stamatopoulou, Ioanna Stamatopoulou, J. Kelemen, J. Klein, M. Gheorghe, M. Holcombe, M. Holcombe, M. Wooldridge, Mario de J. Pérez Jiménez, O. Paunovski, P. Kefalas, P. Kefalas, P. Kefalas, P. Kefalas, P. Kefalas, Paolo Milazzo, Petros Kefalas, R. A. Brooks, S. Curtis, S. Eilenberg, U. Wilensky   +37 more
core   +2 more sources

By dawn or dusk—how circadian timing rewrites bacterial infection outcomes

FEBS Letters, EarlyView.
The circadian clock shapes immune function, yet its influence on infection outcomes is only beginning to be understood. This review highlights how circadian timing alters host responses to the bacterial pathogens Salmonella enterica, Listeria monocytogenes, and Streptococcus pneumoniae revealing that the effectiveness of immune defense depends not only
Devons Mo, Catherine S. Palmer, Jacqueline M. Kimmey   +2 more
wiley   +1 more source

Evaluation of IL-32 rs28372698 and IL-37 rs3811047 polymorphisms and their serum levels in rheumatoid arthritis patients

Egyptian Rheumatology and Rehabilitation
Background Interleukin (IL)-32 and IL-37 are implicated in the pathophysiology of rheumatoid arthritis (RA). The aim of this study is to investigate serum levels and the genotypes of the IL-32 and IL-37 variants (IL-32 (rs28372698) and IL-37 (rs3811047))
Marwa Abdo, Ahmed Elmaghraby, Fatma H. Abdelraouf, Hossam Elashmawy, Hala Ramadan, Eman Elsayed, Shada A. Ghoniem   +6 more
doaj   +1 more source

Blood cytokines as potential predictors of the development of SARS-CoV-2 associated pneumonia in patients with stage II ESSENTIAL hypertension

Инфекция и иммунитет
The search for predictors of the severe course of COVID-19 was relevant both during the pandemic and at the present time. The aim of the study was to analyze the relationship of cytokine levels in patients with EН before SARS-CoV-2 infection with the ...
Olga A. Radaeva, A. S. Simbirtsev, M. S. Iskandyarova, E. V. Negodnova, V. V. Kulyapkin, K. A. Krasnoglazova, V. V. Eremeev   +6 more
doaj   +1 more source

IL-37 inhibits macrophage-mediated plasma cell mastitis [PDF]

Jichu yixue yu linchuang
Objective To investigate whether interleukin-37 (IL-37) affects macrophage M1 polarization via nucleotide oligomerization of structural domain receptor protein 1 (NOD1)/nuclear factor κB (NF-κB) in plasma cell mastitis.
DENG Youyuan, ZHAO Hongjun, YE Lifen, LI Jingyong, ZHANG Huaixiao, ZHANG Chao, WANG Jianguo
doaj   +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source