Results 91 to 100 of about 1,990,850 (192)

Macrophage polarization impacts tunneling nanotube formation and intercellular organelle trafficking. [PDF]

, 2019
Tunneling nanotubes (TNTs) are cellular extensions enabling cytosol-to-cytosol intercellular interaction between numerous cell types including macrophages.
Cherqui, Stephanie, Goodman, Spencer, Khan, Meisha, Naphade, Swati, Sharma, Jay   +4 more
core   +1 more source

Interleukin-4 Causes Susceptibility to Invasive Pulmonary Aspergillosis through Suppression of Protective Type I Responses [PDF]

, 2017
Aspergillus fumigatus, an opportunistic fungal pathogen, causes multiple allergic and non-allergic airway diseases. Invasive pulmonary aspergillosis (IPA) is a nonallergic, life-threatening disease of immunocompromised patients. In a murine model of IPA,
Bacci, Angela, Bachmann, Martin, Bistoni, Francesco, Cenci, Elio, Del Sero, Giuseppe, Fè d'Ostiani, Cristiana, Kopf, Manfred, Mencacci, Antonella, Montagnoli, Claudia, Mosci, Paolo, Romani, Luigina   +10 more
core  

Distinct signal transduction processes by IL-4 and IL-13 and influences from the Q551R variant of the human IL-4 receptor alpha chain

Respiratory Research, 2002
Background Although IL-4 and IL-13 share the IL-13 receptor, IL-13 exhibits unique functions. To elicit the cellular basis of these differences, signal transduction processes have been compared.
Braun Sandra, Kruse Susanne, Deichmann Klaus A   +2 more
doaj   +1 more source

cAMP up-regulates IL-4 and IL-5 production from activated CD4+ T cells while decreasing IL-2 release and NF-AT induction [PDF]

, 2017
Seven days after activation with concanavalin A and irradiated spleen cells, murine CD4+ T cells were re-stimulated with lonomycin and phorbol 12-myristate 13-acetate (PMA). IL-2 and IL-4 were determined in the supernatant.
Arrighi, Jean-François, Cariberg, Carsten, Hauser, Conrad, Lacour, Marc, Müller, Kai M., Saurat, Jean-Hilaire   +5 more
core  

Recent Developments in Monoclonal-Antibody-Based Biologic Therapy for Severe Refractory Eosinophilic Asthma

Antibodies
Background: Asthma exhibits marked heterogeneity both clinically and at the molecular phenotypic level, requiring specifically targeted treatments to block the key pathways of the disease.
Garry M. Walsh
doaj   +1 more source

Reduced Interleukin-4 Receptor α Expression on CD8+ T Cells Correlates with Higher Quality Anti-Viral Immunity

, 2015
With the hope of understanding how interleukin (IL)-4 and IL-13 modulated quality of anti-viral CD8(+) T cells, we evaluated the expression of receptors for these cytokines following a range of viral infections (e.g.
Jackson, Ronald J., Ranasinghe, Charani, Tscharke, David C., Wijesundara, Danushka K.   +3 more
core   +1 more source

Association of IL‐33 in modeling type‐2 airway inflammation and pulmonary emphysema in mice

Immunity, Inflammation and Disease
We developed pulmonary emphysema and a type 2 airway inflammation overlap mouse model. The bronchoalveolar lavage (BAL) interleukin 13 (IL‐13), IL‐4, and IL‐5 levels in the overlap model were higher than in the pulmonary emphysema model and lower than in
Chika Miyaoka, Masato Watanabe, Keitaro Nakamoto, Yuki Yoshida, Aya Hirata, Jumpei Aso, Hiroki Nunokawa, Manabu Ishida, Koujiro Honda, Saori Takata, Takeshi Saraya, Haruyuki Ishii   +11 more
doaj   +1 more source

Distinct cytokine patterns in Occult Hepatitis C and Chronic Hepatitis C Virus Infection [PDF]

, 2011
Background & Aim: The immunopathogenesis of chronic hepatitis C virus (HCV) infection is a matter of great controversy. The imbalance of T-helper lymphocyte cell cytokine production was believed to play an important pathogenic role in ...
Azza Azza Abdel-Aziz, Mohamed Abd-elmaksoud, Mona Elhadidy, Nashwa Abousamra, Nasser Mousa, Yahia Gad   +5 more
core   +1 more source

Thiols Decrease Human IL-4 Production and IL-4-lnduced Immunoglobulin Synthesis [PDF]

International Archives of Allergy and Immunology, 1997
P, Jeannin, Y, Delneste, J P, Aubry, S, Lecoanet-Henchoz, J F, Gauchat, P, Life, J Y, Bonnefoy   +6 more
openaire   +2 more sources

Association of BMI and interleukin gene polymorphism with lifestyle risk factors in diabetes mellitus

MGM Journal of Medical Sciences
Background: Type 2 diabetes mellitus (T2DM) is a significant global health challenge, with a particularly high prevalence among genetically predisposed populations.
Shivangi Singh, Pooja, Shubhangi Chaturvedi, Tridiv Katiyar, Shefali Singh, Dinesh Raj Modi   +5 more
doaj   +1 more source