Results 121 to 130 of about 15,466,885 (336)

Neutralizing monoclonal antibodies define two different functional sites in human interleukin-4 [PDF]

, 1994
Human interleukin-4 (IL-4) is a small four-helix-bundle protein which is essential for organizing defense reactions against macroparasites, in particular helminths.
Arnold, S., Heusser, C., Reusch, P., Sebald, Walter, Wagner, K., Weston, B.   +5 more
core  

IL-4-secreting CD4+ T cells are crucial to the development of CD8+ T-cell responses against malaria liver stages.

, 2002
CD4+ T cells are crucial to the development of CD8+ T cell responses against hepatocytes infected with malaria parasites. In the absence of CD4+ T cells, CD8+ T cells initiate a seemingly normal differentiation and proliferation during the first few days
A Franco, AB Lyons, Alexandre Morrot, C Kurts, DP Dialynas, F Ossendorp, F Zavala, Fidel Zavala, G Sano, Gen-ichiro Sano, H Bodmer, J Ohara, JA Keene, JA Pedras-Vasconcelos, JD Altman, JM McCune, JM Riberdy, JP Ridge, Julius C.R. Hafalla, KS Schluns, L Peng, LH Carvalho, LR Huang, Luzia H. Carvalho, Maria A. Curotto de Lafaille, MH Kaplan, MM Rodrigues, P Borrow, P Romero, RA Tripp, RD Cardin, RJ Armitage, RM Buller, RP Bucy, SO Andreasen, SP Schoenberger, SR Bennett, T Ohteki, T Schuler, W Allan, WE Paul, WE Seaman, WR Weiss, Y Miyahira, Z Lu   +44 more
core   +1 more source

Critical role of NKT cells in posttransplant alloantibody production [PDF]

, 2014
We previously reported that posttransplant alloantibody production in CD8-deficient hosts is IL-4+ CD4+ T cell-dependent and IgG1 isotype-dominant. The current studies investigated the hypothesis that IL-4-producing natural killer T cells (NKT cells ...
Abdel-Rasoul, M., Brutkiewicz, R. R., Bumgardner, G. L., Elzein, S. M., Sanghavi, P. B., Swamy, P., Wright, C. L., Zimmerer, J. M.   +7 more
core   +1 more source

The potential role of T-cells and their interaction with antigen-presenting cells in mediating immunosuppression following trauma-hemorrhage [PDF]

, 2009
Objective: Trauma-hemorrhage results in depressed immune responses of antigen-presenting cells (APCs) and T-cells. Recent studies suggest a key role of depressed T-cell derived interferon (IFN)-g in this complex immune cell interaction.
Abraham E., Angele MK, Angele MK, Christian P. Schneider, Christian R. Walz, Christiane J. Bruns, de Saint-Vis B., Ertel W., Eugen Faist, Florian Loehe, Irshad H. Chaudry, Landy M., Markus Albertsmeier, Martin K. Angele, Ransom J., Siegfried Zedler   +15 more
core   +1 more source

Psychological Safety Among Interprofessional Pediatric Oncology Teams in Germany: A Nationwide Survey

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Psychological safety (PS) is essential for teamwork, communication, and patient safety in complex healthcare environments. In pediatric oncology, interprofessional collaboration occurs under high emotional and organizational demands. Low PS may increase stress, burnout, and adverse events.
Alexandros Rahn, Anna‐Lena Herbach, Christian Bock, Katharina Fleig, Urs Mücke   +4 more
wiley   +1 more source

Generation of interleukin 4 (IL-4)-producing cells in vivo and in vitro: IL-2 and IL-4 are required for in vitro generation of IL-4- producing cells

Journal of Experimental Medicine, 1990
T cell populations derived from naive mice produce very small amounts of interleukin 4 (IL-4) in response to stimulation on anti-CD3-coated dishes. IL-4 production by such cells is mainly found among large- and intermediate-sized T cells and is dependent
G. Gros, S. Ben-Sasson, R. Seder, F. Finkelman, W. Paul   +4 more
semanticscholar   +1 more source

Interferon gamma (IFN -gamma) and interleukin -4 (IL-4) gene variants and cytokine levels in pulmonary tuberculosis. Indian Journal of Medical Research [PDF]

, 2006
Background & objectives: Cytokine gene polymorphisms may alter Th1/Th2 balance with major implications in tuberculosis. The aim of our study was to find out whether Interferon +874A and IL-4 -590T polymorphisms were associated with susceptibility to ...
Adhilakshmi, A R, Jawahar, M S, Narayanan, P R, Prabhu Anand, S, Selvaraj, P, Vidyarani, M   +5 more
core  

IL-4 induces the formation of multinucleated giant cells and expression of ?5 integrin in central giant cell lesion [PDF]

, 2016
It is now well established that IL-4 has a central role in the development of monocytes to multinucleated giant cells (MGCs) by inducing the expression of integrins on the surface of monocytes.
Aghbali, Amirala, Baradaran, Behzad, Kouhsoltani, Maryam, Mohamed Khosroshahi, Leila, Rafieyan, Sona, Shanehbandi, Dariush   +5 more
core   +1 more source

Developmental Disorders in Children Recently Diagnosed With Cancer

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Neurocognitive deficits in adult survivors of childhood cancer are well established, but less is known about developmental disorders (DD) arising shortly after cancer diagnosis. Using 2016–2019 linked Ohio cancer registry and Medicaid data, we compared DD among 324 children with cancer and 606,913 cancer‐free controls.
Jamie Shoag, Long Vu, Ritika Miryala, Jeffrey M. Albert, Molly McVoy, Siran M. Koroukian   +5 more
wiley   +1 more source

IL-4 directly signals tissue-resident macrophages to proliferate beyond homeostatic levels controlled by CSF-1

Journal of Experimental Medicine, 2013
IL-4 and CSF-1 both contribute to macrophage proliferation during nematode infection, but IL-4 permits increased tissue macrophage density without the coincident monocyte infiltration associated with elevated CSF-1 levels.
S. Jenkins, Dominik Ruckerl, G. Thomas, J. Hewitson, Sheelagh Duncan, F. Brombacher, R. Maizels, D. Hume, J. Allen   +8 more
semanticscholar   +1 more source