Results 131 to 140 of about 1,845,267 (245)

PARK(ing) time–How park deficiency affects the biological clock in a Drosophila model of Parkinson's disease

FEBS Letters, EarlyView.
Drosophila park mutants serve as a model for Parkinson's disease. We used this strain to investigate the connection between oxidative stress and the circadian clock mechanism. We showed that increased oxidative stress affects the physiology of pacemaker cells, disrupting their daily structural plasticity. Lack of rhythmic signaling from pacemaker cells
Kamila Zientara, Kinga Skoczek, Elzbieta Pyza, Milena Damulewicz   +3 more
wiley   +1 more source

IL-4-mediated monocyte differentiation modulates CD163 expression and PRRSV infection. [PDF]

Front Microbiol
Kim N, Ju YJ, Kye YC, Kim CG, Pyung YJ, Park DJ, You SJ, Ka H, Han SH, Yun CH.   +9 more
europepmc   +1 more source

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

FEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee, Junho Jeong, Chae Yeong Lee, Hyunjoon Cho, Man Hwan Oh, Je Chul Lee, Jee‐Young Lee, Yangmee Kim   +7 more
wiley   +1 more source

Bronchodilator response is linked with uncontrolled moderate-to-severe childhood asthma and elevated IL-4 and IL-13. [PDF]

Pediatr Allergy Immunol
Metwally NKA, Hashimoto S, Vijverberg SJH, Neerincx AH, Dierdorp BS, Dekker T, Haarman EG, Duitman JW, Gorenjak M, Toncheva AA, Harner S, Brandstetter S, Wolff C, Corcuera-Elosegui P, López-Fernández L, Sardón-Prado O, Pino-Yanes M, Potočnik U, Kabesch M, Kraneveld AD, Lutter R, Terheggen-Lagro SWJ, Abdel-Aziz MI, Maitland-van der Zee AH, SysPharmPediA Consortium.   +24 more
europepmc   +1 more source

α‐Synuclein aggregation landscape from phase separation to neurotoxic intermediates

FEBS Letters, EarlyView.
Alpha‐synuclein aggregation in Parkinson's disease involves a complex landscape of transient intermediates, including oligomers, fibrils and liquid–liquid phase separation (LLPS). A view is emerging in which LLPS maturation into solid‐like condensates may contribute to the formation of neurotoxic species.
Silvia Arino, Giuliana Fusco, Alfonso De Simone   +2 more
wiley   +1 more source

IL-4 Correlates With Bone Mineral Density in Men, and IL-4 Depletion May Drive Bone Loss in Men With HIV. [PDF]

J Infect Dis
Ofotokun I, Titanji K, Dabeer S, Tripathi AK, Bedi B, Kirkpatrick CM, Nguyen TB, Weitzmann MN.   +7 more
europepmc   +1 more source

Three phosphatase families form a community: The phosphohydrolases that act upon inositol pyrophosphates

FEBS Letters, EarlyView.
Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley   +1 more source

IL-4 triggers salivary duct dilatation via SHH signaling and exacerbates Sjögren's disease. [PDF]

Cell Rep
Zhang J, Zhang J, Zhao Y, Yang X, Li J, Chen W, Wang X, Shi X, Chang X, Sun Q, Chen W, Wang F.   +11 more
europepmc   +1 more source

Modelling stem cell differentiation related processes—A practical overview for biologists

FEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar, Xinqi Yan, Lucas F. Jansen Klomp, Stefano Schivo, Janine N. Post   +4 more
wiley   +1 more source

The Generation of Therapeutic Fc Fusion Proteins to Trap Both IL-4 and IL-13. [PDF]

Juntendo Med J
Miyazaki S, Kaitani A, Izawa K, Ando T, Maehara A, Nakano N, Ogawa H, Okumura KO, Kitaura J.   +8 more
europepmc   +1 more source