Results 161 to 170 of about 1,990,850 (192)
Some of the next articles are maybe not open access.
Probabilistic Regulation of IL-4 Production
Journal of Clinical Immunology, 2005Among a population of uniformly differentiated TH(2) cells, only a portion express IL-4 upon stimulation and those that do often express the product of only a single allele. We review the evidence for the basis of IL-4 monoallelism and argue that it depends upon probabilistic expression of the Il4 gene.
Liying, Guo +2 more
openaire +2 more sources
Transplantation, 1997
We analyzed cytokine expression in recipient spleens and cardiac allografts placed in mice that were unable to synthesize interleukin (IL)-4 due to disruption of the IL-4 gene (IL-4 -/-) and in wild-type (IL-4 +/+) mice. Polyclonal BL-4P and monoclonal 11B11, 1D11, and 24G2 anti-IL-4 antibodies were used to detect cell-surface and cytoplasmic antigens ...
P L, Mottram +4 more
openaire +1 more source
We analyzed cytokine expression in recipient spleens and cardiac allografts placed in mice that were unable to synthesize interleukin (IL)-4 due to disruption of the IL-4 gene (IL-4 -/-) and in wild-type (IL-4 +/+) mice. Polyclonal BL-4P and monoclonal 11B11, 1D11, and 24G2 anti-IL-4 antibodies were used to detect cell-surface and cytoplasmic antigens ...
P L, Mottram +4 more
openaire +1 more source
1995
Abstract The nucleotide sequences of IL-4 cDNAs cloned from mouse and man (GenBank accession numbers M13238 and M13982) predict a protein of 153 (human) or 140 (mouse) amino acids, each containing a 20-amino-acid leader sequence (Lee et al. 1986; Noma et al. 1986; Yokota et al. 1986).
M Howard, N Harada
openaire +1 more source
Abstract The nucleotide sequences of IL-4 cDNAs cloned from mouse and man (GenBank accession numbers M13238 and M13982) predict a protein of 153 (human) or 140 (mouse) amino acids, each containing a 20-amino-acid leader sequence (Lee et al. 1986; Noma et al. 1986; Yokota et al. 1986).
M Howard, N Harada
openaire +1 more source
The IL-4 Receptor — Signaling Mechanisms
1994Interleukin-4 (IL-4) is a multifunctional cytokine that is a member of the hematopoietin family1. Its structure consists of a bundle of four left handed α helices in which the first and second and the third and fourth helices are connected by long over hand loops2,3,4,5.
A, Keegan, K, Nelms, W E, Paul
openaire +2 more sources
Gan to kagaku ryoho. Cancer & chemotherapy, 1994
Helper T cells can be divided into Th1 type cell which produces IL-2 and IFN-gamma and Th2 type cell which produces IL-4, IL-5, and IL-6. In general, cytokine has a pleiotropic action. Furthermore cytokines have redundancy in their action. IL-4 is a major product of Th 2 type cell and is an essential cytokine for IgE production, which is also induced ...
N, Nagai +3 more
openaire +1 more source
Helper T cells can be divided into Th1 type cell which produces IL-2 and IFN-gamma and Th2 type cell which produces IL-4, IL-5, and IL-6. In general, cytokine has a pleiotropic action. Furthermore cytokines have redundancy in their action. IL-4 is a major product of Th 2 type cell and is an essential cytokine for IgE production, which is also induced ...
N, Nagai +3 more
openaire +1 more source