Results 151 to 160 of about 1,863,297 (279)

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

[Interleukin-5 (IL-5)].

Nihon rinsho. Japanese journal of clinical medicine, 1996
T, Yasue, Y, Kikuchi, K, Takatsu
openaire   +4 more sources

Eosinophilic pediatric ABPM lacking fungal sensitization responsive to anti-IL-5. [PDF]

J Allergy Clin Immunol Glob
Mizutani M, Nomura T, Nakaoka A, Tanida H, Kanemitsu Y, Hizuka K, Ueki S, Saitoh S.   +7 more
europepmc   +1 more source

Conserved structural motifs in PAS, LOV, and CRY proteins regulate circadian rhythms and are therapeutic targets

FEBS Letters, EarlyView.
Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman, Anna E. Lester, Brian D. Zoltowski   +2 more
wiley   +1 more source

Proteomic Identification of Plasma Biomarkers of Response to IL-5 Inhibitor Biologics in Healthy Subjects. [PDF]

Clin Transl Sci
Chekka LMS, Samarth DP, Howard KE, Guo Y, Mohamed EG, Decker E, Wheeler W, Wommack J, Gogain J, Deering J, Schrieber SJ, Wang YM, Strauss DG, Florian J, Hyland PL.   +14 more
europepmc   +1 more source

Influence of anti-interleukin (IL)-5/anti-IL-5 receptor-α treatment on work productivity in patients with severe eosinophilic asthma. [PDF]

ERJ Open Res, 2023
Drick N, Brinkmann L, Fuge J, Welte T, Suhling H.   +4 more
europepmc   +1 more source

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

FEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva, Ariann E. Mendoza‐Martínez, P. Abril Medina‐Flores, Carlos Campero‐Basaldua, Alexander DeLuna, Soledad Funes   +5 more
wiley   +1 more source

Anti-IL-5 and anti-IL-5 receptor therapy significantly improves quality of life and FEV1 values in patients with severe asthma. [PDF]

Allergy Asthma Clin Immunol
Alfaro AOV, Vargas HCG, Díaz JM, Pinto JA, Cambero DCG, Cuellar EH, Zapata JAP, Domínguez AEL, Zapata JP, Ponce-Campos SD.   +9 more
europepmc   +1 more source

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

FEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka, Yuxi Liu, Stefano Maggi, Debnath Ghosal, Jue Wang, Prashant P. Damke, Stephen D. Carter, Wei Zhao, Sukhithasri Vijayrajratnam, Joseph P. Vogel, Carrie L. Shaffer, Grant J. Jensen   +11 more
wiley   +1 more source

Vitamin D status in hospitalized COVID‑19 patients is associated with disease severity and IL-5 production. [PDF]

Virol J, 2023
Qiu Y, Bao W, Tian X, Zhang Y, Pan Y, Xie G, Bao A, Yin D, Zhang M, Zhou Y.   +9 more
europepmc   +2 more sources