Results 171 to 180 of about 17,201,482 (284)

IL-5/IL-5R blockade enables safe non-steroidal anti-inflammatory agent reintroduction in non-steroidal anti-inflammatory exacerbated respiratory disease. [PDF]

Front Immunol
Korkmaz P, Kahveci N, Demir S, Yegit OO, Unal D, Igde MH, Sezgin ME, Aslan AF, Erden B, Bolek L, Atasever MD, Guzel SE, Kamacı ŞÇ, Kaya E, Gelincik A.   +14 more
europepmc   +1 more source

Structural and biochemical analysis of a B12 superbinder

FEBS Letters, EarlyView.
BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices, Jacob J. Whittaker, Dirk J. Slotboom, Albert Guskov   +3 more
wiley   +1 more source

Introduzione. Il dettaglio come luogo di svelamento del progetto

Il dettaglio è il luogo in cui il progetto si svela. Non solo per dichiarazione intenzionale o per valore espressivo, ma perché è costretto a perdere ambiguità.
Anna Del Monaco
core  

Targeting Eosinophils in Asthmatic Inflammation: Benefits and Drawbacks

Journal of Inflammation Research
David Broide Department of Medicine, University of California San Diego, La Jolla, CA, 92093-0635, USACorrespondence: David Broide, Department of Medicine, University of California San Diego, La Jolla, CA, 92093-0635, USA, Email dbroide@health.ucsd ...
Broide D
doaj  

Eosinophilic pediatric ABPM lacking fungal sensitization responsive to anti-IL-5. [PDF]

J Allergy Clin Immunol Glob
Mizutani M, Nomura T, Nakaoka A, Tanida H, Kanemitsu Y, Hizuka K, Ueki S, Saitoh S.   +7 more
europepmc   +1 more source

Structures of mycobacterial 3‐methylcrotonyl‐CoA carboxylase reveal carrier‐domain translocation between catalytic sites

FEBS Letters, EarlyView.
Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav, Bogdan I. Florea, Sebastian Geibel   +2 more
wiley   +1 more source

Bronchial asthma and interleukin-5

Respiratory Research, 2001
Das Undurti, Leckie MJ, Brinke A, Khan J, Diamant Z, O'Connor BJ, Walls CM, Mathur AK, Cowley HC, Chung KF, Djukanovic R, Hansel TT, Holgate ST, Sterk PJ, Barnes PJ   +14 more
doaj   +1 more source

Antagonism of cytokine-induced eosinophil accumulation in asthma

Frontiers in Pharmacology, 2012
Garry M Walsh
doaj   +1 more source

IL-5 CAR-T cell therapy induces effective remission in hypereosinophilic disorders. [PDF]

J Hematol Oncol
Wu Y, Zhang R, Sun B, Chen G, Xu F, Chen X, Zeng J, Shen D, Shi F, Pan S, Yao B, Tang H, Shao Z, Wu Q, Shao J, Zhang C, Wang D, Hu Y, Ying S.   +18 more
europepmc   +1 more source

From junk to function — How weak selection in eukaryotes builds new parts and drives genomic complexity

FEBS Letters, EarlyView.
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley   +1 more source