Results 171 to 180 of about 1,897,678 (279)

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

FEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

Eosinophilic Myocarditis Treated with IL-5 Blockade: An Integrated Case Report and Literature Review. [PDF]

J Clin Med
Takahashi H, Awaya T, Nagamatsu H, Satake Y, Hirose R, Toba N, Toyama-Kousaka M, Ota S, Morikawa M, Tajiri Y, Agemi Y, Nakano N, Shinkai M.   +12 more
europepmc   +1 more source

Treatment with interleukin (IL)-5/IL-5 receptor antibodies in patients with severe eosinophilic asthma and COPD. [PDF]

ERJ Open Res, 2022
Drick N, Fuge J, Seeliger B, Speth M, Vogel-Claussen J, Welte T, Suhling H.   +6 more
europepmc   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Targeting Eosinophils in Asthmatic Inflammation: Benefits and Drawbacks

Journal of Inflammation Research
David Broide Department of Medicine, University of California San Diego, La Jolla, CA, 92093-0635, USACorrespondence: David Broide, Department of Medicine, University of California San Diego, La Jolla, CA, 92093-0635, USA, Email dbroide@health.ucsd ...
Broide D
doaj  

Coronary Vasospasm in Eosinophilic Granulomatosis With Polyangiitis Presenting as Acute Coronary Syndrome Treated With Anti-IL-5. [PDF]

JACC Case Rep
Thota P, Sharma S, Mohammed U.
europepmc   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Beyond BMI: visceral adiposity assessed by the lipid accumulation product index shows independent associations with IL-5 and TNF-β in older adults. [PDF]

Aging Clin Exp Res
Mancinetti F, Bastiani P, Alunno M, Tecchio V, Scamosci M, Cecchetti R, Mecocci P, Boccardi V.   +7 more
europepmc   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

Plasma IL-5 but Not CXCL13 Correlates With Neutralization Breadth in HIV-Infected Children [PDF]

, 2019
Adland, E., Goulder, P., Groll, A., Kløverpris, H., Leslie, A., Moore, P., Morris, L., Muenchhoff, M., Ndung'u, T., Ogongo, P., Porterfield, J., Roider, J.   +11 more
core   +1 more source