Results 51 to 60 of about 1,897,678 (279)

The role of epithelial alarmins and Th2 cytokines in the inflammatory response in allergic rhinitis

Сибирский научный медицинский журнал
Allergic rhinitis (AR) occupies a leading position among the causes of morbidity throughout the world, to date, it has been diagnosed in 400 million people.
V. V. Makarevich, A. D. Taganovich, T. V. Mironova, I. P. Shilovskiy, M. R. Khaitov, A. G. Kadushkin   +5 more
doaj   +1 more source

Personalized Selumetinib Dosing in Pediatric Neurofibromatosis Type 1: Insights From a Pilot Therapeutic Drug Monitoring Study

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Objective To evaluate selumetinib exposure using therapeutic drug monitoring (TDM) in pediatric patients with neurofibromatosis type 1 (NF1) and plexiform neurofibromas (PN), assess interpatient pharmacokinetic variability, and explore the relationship between drug exposure, clinical response, and adverse effects.
Janka Kovács, Zoltán Köllő, Balázs Gellért Karvaly, Mahmoud Obeidat, Rita Nagy, Péter Hegyi, Brigitta Teutsch, Eszter Tuboly, Miklós Garami   +8 more
wiley   +1 more source

Immunoregulatory functions for murine intraepithelial lymphocytes: gamma/delta T cell receptor-positive (TCR+) T cells abrogate oral tolerance, while alpha/beta TCR+ T cells provide B cell help. [PDF]

, 1992
Past work has shown that a subset of effector T cells with unique characteristics could abrogate hapten- or antigen-induced tolerance, and the reconstitution of this immune response has been termed contrasuppression.
Aicher, WK, Bluestone, JA, Eldridge, JH, Fujihashi, K, Kiyono, H, McGhee, JR, Taguchi, T   +6 more
core  

Regulation of Proliferation, Differentiation and Survival by the IL-3/IL-5/GM-CSF Receptor Family [PDF]

, 1998
The receptors for the Il-3/IL-5/GM-CSF cytokine family are composed of a heterodimeric com-plex of a cytokine-specific a chain and a common ß chain (ßc).
Coffer, P.J., Groot, Rolf P. de, Koenderman, L.   +2 more
core   +1 more source

Molecular characterization of the β chain of the murine interleukin 5 receptor [PDF]

, 2017
Interleukin 5 (IL-5) is a multifunctional cytokine that regulates the proliferation and differentiation of hematopoietlc cells Including B cells and eosinophlls.
Hitoshi, Yasumichi, Mita, Seiji, Rolink, Antonius G., Takaki, Satoshi, Takatsu, Kiyoshi, Tominaga, Akira, Yamaguchi, Naoto   +6 more
core  

Clusters of cytokines determine malaria severity in Plasmodium falciparum - Infected patients from endemic areas of central India [PDF]

, 2006
We investigated the role of interferon (IFN)- gamma , interleukin (IL)-1 beta , IL-2, IL-4, IL-5, IL-6, IL-10, IL-12, tumor necrosis factor (TNF)- alpha , and transforming growth factor (TGF)- beta in clinically well-defined groups of Plasmodium ...
Cazenave, P.A., Fesel, C., Jain, R., Mishra, G.C., Pied, S., Prakash, D.   +5 more
core   +1 more source

Benralizumab, an add-on treatment for severe eosinophilic asthma: evaluation of exacerbations, emergency department visits, lung function, and oral corticosteroid use

Therapeutics and Clinical Risk Management, 2018
Diego Jose Maselli,1 Linda Rogers,2 Jay I Peters1 1Division of Pulmonary Diseases and Critical Care, University of Texas Health, San Antonio, TX, USA; 2Division of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine Mount Sinai &ndash ...
Maselli DJ, Rogers L, Peters JI
doaj  

Adherence to Protocol Recommendations for Children With Wilms Tumour in Two Consecutive Studies in the United Kingdom and Ireland—Does Variation Matter?

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background and Aims Wilms tumour (WT) has excellent event‐free and overall survival (OS). However, small differences exist between countries participating in the same international study. This led us to examine variation in adherence to protocol recommendations as a potential contributing factor.
Suzanne Tugnait, R. Al‐Saadi, A. Lopez‐Cortes, K. Dzhuma, M. Oostveen, J. Brok, S. Irtan, M. Weeks, J. Bate, S. Baker, R. Williams, M. Powis, D. Saunders, O. Olsen, T. Watson, S. Shelmerdine, S. Vaidya, L. Howell, C. Duncan, G. M. Vujanic, C. Stiller, G. P. Balchin, T. Chowdhury, K. Pritchard‐Jones   +23 more
wiley   +1 more source

CCR8 leads to eosinophil migration and regulates neutrophil migration in murine allergic enteritis [PDF]

, 2019
Allergic enteritis (AE) is a gastrointestinal form of food allergy. This study aimed to elucidate cellular and molecular mechanisms of AE using a murine model. To induce AE, BALB/c wild type (WT) mice received intraperitoneal sensitization with ovalbumin
Blanco Pérez, Frank, Burggraf, Manja, Gonzalez Menendez, Irene, Iwakura, Yoichiro, Kato, Yoichiro, Kirberg, Jörg, Krause, Maren, Laiño, Jonathan Emiliano, Martella, Manuela, Ohbayashi, Masaharu, Quintanilla Martinez, Leticia, Scheurer, Stephan, Shibata, Noriyuki, Toda, Masako, Vieths, Stefan   +14 more
core   +1 more source

Sirolimus for Extracranial Arteriovenous Malformations: A Scoping Review of the Evidence in Syndromic and Non‐Syndromic Cases

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Arteriovenous malformations (AVMs) are rare, high‐flow, vascular anomalies that can occur either sporadically or as part of a genetic syndrome. AVMs can progress with serious morbidity and even mortality if left unchecked. Sirolimus is an mTOR inhibitor that is effective in low‐flow vascular malformations; however, its role in AVMs is unclear.
Will Swansson, Ingrid Winship, Gary Hammerschlag, Laura Scardamaglia   +3 more
wiley   +1 more source