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Mass Cytometry, Imaging Mass Cytometry, and Multiplexed Ion Beam Imaging Use in a Clinical Setting
Clinics in Laboratory Medicine, 2021Mass cytometry (MC), imaging mass cytometry (IMC), and multiplexed ion beam imaging (MIBI) represent a new generation of tools to understand increasingly complex systems. Although these technologies differ in their intended applications, with MC being most similar to flow cytometry, and IMC/MIBI being similar to immunohistochemistry, they all share a ...
Raymond D Devine, Gregory K Behbehani
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Automated Cell Phenotyping for Imaging Mass Cytometry
2022 44th Annual International Conference of the IEEE Engineering in Medicine & Biology Society (EMBC), 2022Imaging mass cytometry (IMC) is a new advancement in tissue imaging that is quickly gaining wider usage since its recent launch. It improves upon current tissue imaging methods by allowing for a significantly higher number of proteins to be imaged at once on a single tissue slide. For most analyses of IMC data, determining the phenotype of each cell is
Sindhura Thirumal +4 more
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Imaging Mass Cytometry in Immuno-Oncology
2023In situ profiling of the tumor-immune microenvironment (TiME) requires the ability to co-localize and detect multiple proteins simultaneously. Imaging mass cytometry (IMC), using the Hyperion™ imaging system is a novel multiplex imaging modality that currently enables detection of up to 50 markers on fixed tissues at subcellular resolution and thus has
Tiziana, Cotechini +2 more
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Testing a Nanoparticle Reagent for Imaging Mass Cytometry
BiomacromoleculesMass cytometry (MC), a powerful single-cell analysis technique, has limitations in detecting low-abundance biomarkers. Nanoparticle (NP) reagents offer the potential for enhancing sensitivity by carrying large numbers of heavy metal isotopes. Here, we report NP reporters for imaging mass cytometry (IMC) based on NaYF4:Yb3+/Er3+ NPs.
Mahtab Abtahi +9 more
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Imaging mass cytometry - elemental immunohistochemistry for multiparametric imaging and quantitation
The Journal of Immunology, 2016Abstract Pathology assessment of tissue sections provides prognostic evaluation and helps select optimum treatment regimens. Digital pathology has made significant strides in the analysis of several markers. There is a growing understanding of cell heterogeneity within tumor tissue, role of microenvironment, and the impact of immune ...
Olga Ornatsky +6 more
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Imaging Mass Cytometry for In Situ Immune Profiling
The complexities and cellular heterogeneity associated with tissues necessitate the concurrent detection of markers beyond the limitations of conventional imaging approaches in order to spatially resolve the relationships between immune cell populations and their environments.Kevin, Hu +2 more
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Spatial immunophenotyping of FFPE tissues by imaging mass cytometry
The immune compartment of a tissue is dynamic, changing to respond to infections, tumors, or therapeutic interventions. Within tissues, local microenvironments provide interaction partners and cytokines that can gear immune cells into distinct functional states. Thus, it is not just the immune composition of a tissue, but also the relative localizationCarolina, Mangana, Barbara B, Maier
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