Results 41 to 50 of about 7,247 (206)
Identification of New CD36 Antagonists by Structure‐Based Virtual Screening
Chemical Biology &Drug Design, Volume 106, Issue 5, November 2025.Virtual screening identified drug‐like molecules as potential CD36 antagonists; some of them inhibited CD36 function in relevant cellular models. These antagonists could drive the development of CD36‐targeted therapies. ABSTRACT CD36 is a transmembrane glycoprotein that facilitates the uptake of fatty acids and oxidized low‐density lipoproteins.
Sandra L. Guerrero‐Rodríguez +8 more
wiley +1 more source
Fused Heterocycles: Synthesis of Some New Imidazo[1,2-a]- pyridine Derivatives [PDF]
Molecules, 2004 Some new thiazolidines and spirothiazolidines derived from hydrazones of2-methylimidazo[1,2-a]pyridine-3-carboxylic acid hydrazide, a bioisosteric derivative ofisoniazid, were synthesized and characterized by analytical, IR, 1H- and 13C-NMR andmass spectral data.
Zafer Cesur, Birgul Ozden Kasimogullari
openaire +3 more sources
A Dive Into Forty Years of Research on Organic Superbases: From Design to Applications
Journal of Computational Chemistry, Volume 46, Issue 28, October 30, 2025.This review covers the design and application of various neutral organic superbases with carbon, nitrogen, boron, silicon and germanium centers as basic sites. Their utility as organocatalysts has been reported with particular attention given to applications of commercially accessible organic superbases in some pivotal reactions.
Rabindranath Lo, Bishwajit Ganguly
wiley +1 more source
Imidazo[1,2-a]pyridin-3-amines as HIV-1 nonucleoside reverse transcriptase inhibitors (NNRTIs) [PDF]
, 2018 A dissertation submitted to the Faculty of Science University of the Witwatersrand Johannesburg in fulfillment for the requirements of the degree of Master of Science, February 2018Imidazo[1,2-a]pyridin-3-amine compounds have been reported to exhibit ...
core
Visible‐Light‐Promoted Dearomatization for The Construction of Imidazole Scaffolds
Advanced Synthesis &Catalysis, Volume 367, Issue 20, October 29, 2025.Lighting up flat aromatics: a visible‐light photocatalytic dearomative acylation of imidazo[1,2‐a]pyridines using α‐keto acids as sustainable acyl radical precursors is reported, leading to dual fluorescent imidazoles. Dearomatization is a powerful strategy for constructing complex carbocycles and heterocycles, though it typically relies on harsh ...
Silvia Roscales, Aurelio G. Csáky
wiley +1 more source
Amidine Syntheses from Classic to Contemporary for Medicinal Lead Compounds and Natural Products
European Journal of Organic Chemistry, Volume 28, Issue 40, October 29, 2025.A revolution is underway in the synthesis of amidines with new methods unlocking complex, highly substituted amidines or closely related derivatives such as N‐sulfonyl amidines. This review surveys recent advances in amidines and related compounds, including methods to install them and bioactive molecules prominently featuring the amidine functionality.
Wyatt R. Swift‐Ramirez +1 more
wiley +1 more source
ChemMedChem, Volume 20, Issue 20, October 15, 2025.Herein, X‐ray structure‐based design, synthesis, and evaluation of a series of potent and selective small molecules G protein‐coupled receptor kinase 5 (GRK5) and GRK6 inhibitors that exhibit high selectivity against GRK2 are reported. A high‐resolution X‐ray crystal structure of GRK5 and inhibitor 6t complex provides important molecular insight for ...
Arun K. Ghosh +5 more
wiley +1 more source
European Journal of Organic Chemistry, Volume 28, Issue 37, October 11, 2025.A convenient and scalable Ni‐catalyzed anti‐Marovnikov hydroaryation non‐functionalized olefins has been developed. The majority of C–C coupling reactions between arenes and olefins result in the formation of branched isomer products, exhibiting what is known as Markovnikov selectivity. However, alternative catalytic strategies are required to modulate
Edson Leonardo Scarpa de Souza +4 more
wiley +1 more source