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Imidazole: Synthesis, Functionalization and Physicochemical Properties of a Privileged Structure in Medicinal Chemistry

Molecules, 2023
Imidazole was first synthesized by Heinrich Debus in 1858 and was obtained by the reaction of glyoxal and formaldehyde in ammonia, initially called glyoxaline.
Heber Victor Tolomeu, Carlos Alberto Manssour Fraga   +1 more
doaj   +2 more sources

Imidazole Hybrids: A Privileged Class of Heterocycles in Medicinal Chemistry with New Insights into Anticancer Activity [PDF]

Molecules
Imidazole is a five-membered heterocyclic system featuring two nitrogen heteroatoms at the 1- and 3-positions of the ring. The imidazole scaffold is particularly suited for kinase inhibition concepts.
Zarifa Murtazaeva, Azizbek Nasrullaev, Anvarjon Buronov, Shukhrat Gaybullaev, Lifei Nie, Sodik Numonov, Zohidjon Khushnazarov, Davron Turgunov, Rustamkhon Kuryazov, Jiangyu Zhao, Khurshed Bozorov   +10 more
doaj   +2 more sources

Endowing imidazole derivatives with thermally activated delayed fluorescence and aggregation‐induced emission properties for highly efficient non‐doped organic light‐emitting diodes

Aggregate, 2022
The development and enrichment of high‐performance organic fluorophores that simultaneously possess thermally activated delayed fluorescence (TADF) and aggregation‐induced emission (AIE) properties is going pursued but remains a great challenge due to ...
Ge Yang, You Ran, Yimin Wu, Minqi Chen, Zhengyang Bin, Jingsong You   +5 more
doaj   +2 more sources

Review of pharmacological effects of imidazole derivatives [PDF]

Ķazaķstannyṇ Klinikalyķ Medicinasy, 2022
Imidazole derivatives are the perspective class of drugs with a broad spectrum of application in medicine. Imidazole is a nitrogen-containing heterocyclic ring; it has two equivalent forms; hydrogen atom may be located on any of two nitrogen atoms ...
Daniya Serdaliyeva, Talgat Nurgozhin, Elmira Satbayeva, Malika Khayitova, Aida Seitaliyeva, Larisa Ananyeva   +5 more
doaj   +1 more source

Acid Dissociation Constants of the Benzimidazole Unit in the Polybenzimidazole Chain: Configuration Effects

Molecules, 2022
The acid dissociation constant of three benzimidazoles, namely 2,2′-bibenzo[d]imidazole, 2,5′-bibenzo[d]imidazole, and 5,5′-bibenzo[d]imidazole, have been investigated by means of density functional theory calculations in gas phase and in aqueous ...
Liudmil Antonov, Susumu Kawauchi, Kei Shirata   +2 more
doaj   +1 more source

Imidazoles as Potential Anticancer Agents: An Update on Recent Studies

Molecules, 2021
Nitrogen-containing heterocyclic rings are common structural components of marketed drugs. Among these heterocycles, imidazole/fused imidazole rings are present in a wide range of bioactive compounds.
Pankaj Sharma, Chris LaRosa, Janet Antwi, Rajgopal Govindarajan, Karl A. Werbovetz   +4 more
doaj   +1 more source

Study on tri-imidazole derivatives modified with triazine-trione structure as latent curing agents for epoxy resin

SN Applied Sciences, 2021
In this paper, four novel kinds of triazine-trione based tri-imidazole derivatives (IM-TT, 2MI-TT, 2EI-TT and EMI-TT) were synthesized through the addition reaction between triglycidyl isocyanurate (TGIC) and imidazole (IM), 2-methylimidazole (2MI), 2 ...
Xiaodong Wan, Jianben Liu, Xi Chen, Jun Wang   +3 more
doaj   +1 more source

Mechanism of imidazole inhibition of a GH1 β‐glucosidase

FEBS Open Bio, 2023
Imidazole is largely employed in recombinant protein purification, including GH1 β‐glucosidases, but its effect on the enzyme activity is rarely taken into consideration.
Rafael S. Chagas, Felipe A. M. Otsuka, Mario A. R. Pineda, Roberto K. Salinas, Sandro R. Marana   +4 more
doaj   +1 more source

Synthesis, Characterization and Preliminary Antibacterial Evaluation against Staphylococcus aureus of a New 2,4,5-Tri(hetero)arylimidazole Derivative Based on Azaindole Heterocycle

Chemistry Proceedings, 2021
Imidazole derivatives are known for their varied biological applications, such as antibacterial, antifungal, antioxidant, antiviral, antiparasitic and anticancer compounds, among others. Therefore, numerous imidazole derivatives have been synthesized and
Nuna L. P. Ramos, Rui Oliveira, Susana P. G. Costa, Maria Manuela M. Raposo   +3 more
doaj   +1 more source

Cholinesterase-like organocatalysis by imidazole and imidazole-bearing molecules [PDF]

Scientific Reports, 2017
AbstractOrganocatalysis, which is mostly explored for its new potential industrial applications, also represents a chemical event involved in endogenous processes. In the present study, we provide the first evidence that imidazole and imidazole derivatives have cholinesterase-like properties since they can accelerate the hydrolysis of acetylthiocholine
NIERI, PAOLA, CARPI, SARA, FOGLI, STEFANO, POLINI, BEATRICE, BRESCHI, MARIA CRISTINA, PODESTA', ADRIANO   +5 more
openaire   +4 more sources