Results 1 to 10 of about 301,905 (329)

Synthesis and Quantitative Structure–Activity Relationship of Imidazotetrazine Prodrugs with Activity Independent of O6-Methylguanine-DNA-methyltransferase, DNA Mismatch Repair and p53. [PDF]

, 2013
The antitumor prodrug Temozolomide is compromised by its dependence for activity on DNA mismatch repair (MMR) and the repair of the chemosensitive DNA lesion, O6-methylguanine (O6-MeG), by O6-methylguanine-DNA-methyltransferase (EC 2.1.1.63, MGMT). Tumor
Arris C. E., Arrowsmith J., Barvaux V. A., Boberg F., Boyd M. R., Bunz F., Damera K., Darkes M. J. M., De K., Denny B. J., Dimitrios Pletsas, Dinca E. B., Elrashied A. E. Garelnabi, Garelnabi E. A. E., Hirose Y., Honnalli S. S., Judson P. L., Karran P., Karran P., Kotera M., Leteurtre F., Li Li, Liu L., McElhinney R. S., McGarrity J. F., Mladek A. C., Nishizuka S., Pletsas D., Richard T. Wheelhouse, Roger M. Phillips, Sarkaria J. N., Schmidt B. F., Schmiedekamp A., Shealy Y. F., Siddiqui A. A., Smith R. H., Stevens M. F. G., Svilar D., Wang Y., Wheelhouse R. T., Wheelhouse R. T., Zhang J., Zhang J.   +42 more
core   +1 more source

(E)-3-[4-(1H-Imidazol-1-yl)phenyl]-1-(4-methylphenyl)prop-2-en-1-one

Molbank, 2021
Imidazole-containing chalcones have been shown to be strongly effective against Aspergillusfumigatus, the causative agent for the disease pulmonary aspergillosis. Claisen–Schmidt condensation of 4-(1H-imidazol-1-yl)benzaldehyde with 4′-methylacetophenone
Nicholas Bailey, Bradley O. Ashburn
doaj   +1 more source

Advances in the Synthesis of Ring-Fused Benzimidazoles and Imidazobenzimidazoles

Molecules, 2021
This review article provides a perspective on the synthesis of alicyclic and heterocyclic ring-fused benzimidazoles, imidazo[4,5-f]benzimidazoles, and imidazo[5,4-f]benzimidazoles.
Martin Sweeney, Darren Conboy, Styliana I. Mirallai, Fawaz Aldabbagh   +3 more
doaj   +1 more source

Cholinesterase-like organocatalysis by imidazole and imidazole-bearing molecules [PDF]

Scientific Reports, 2017
AbstractOrganocatalysis, which is mostly explored for its new potential industrial applications, also represents a chemical event involved in endogenous processes. In the present study, we provide the first evidence that imidazole and imidazole derivatives have cholinesterase-like properties since they can accelerate the hydrolysis of acetylthiocholine
NIERI, PAOLA, CARPI, SARA, FOGLI, STEFANO, POLINI, BEATRICE, BRESCHI, MARIA CRISTINA, PODESTA', ADRIANO   +5 more
openaire   +3 more sources

Crystal structure of 1-(2,6-diisopropylphenyl)-1H-imidazole

Acta Crystallographica Section E: Crystallographic Communications, 2023
The crystal structure of the title compound, C15H20N2 or DippIm, is reported. At 106 (2) K, the molecule has monoclinic P21/c symmetry with four molecules in the unit cell.
Neil Dudeja, Briana C. Arreaga, Jacob P. Brannon, S. Chantal E. Stieber   +3 more
doaj   +1 more source

Two-dimensional protein crystallization via metal-ion coordination by naturally occurring surface histidines [PDF]

, 1996
A powerful and potentially general approach to the targeting and crystallization of proteins on lipid interfaces through coordination of surface histidine residues to lipid-chelated divalent metal ions is presented.
Arnold, Frances H., Chen, Chao-Tsen, Chilkoti, Ashutosh, Frey, Wolfgang, Pack, Daniel W., Schief, William R., Jr., Stayton, Patrick, Vogel, Viola   +7 more
core   +1 more source

Dual role of imidazole as activator/inhibitor of sweet almond (Prunus dulcis) β-glucosidase

Biochemistry and Biophysics Reports, 2017
The activity of Prunus dulcis (sweet almond) β-glucosidase at the expense of p-nitrophenyl-β-d-glucopyranoside at pH 6 was determined, both under steady-state and pre-steady-state conditions. Using crude enzyme preparations, competitive inhibition by 1–5 
Sara Caramia, Angela Gala Morena Gatius, Fabrizio dal Piaz, Denis Gaja, Alejandro Hochkoeppler   +4 more
doaj   +1 more source

Scope of tetrazolo[1,5-a]quinoxalines in CuAAC reactions for the synthesis of triazoloquinoxalines, imidazoloquinoxalines, and rhenium complexes thereof

Beilstein Journal of Organic Chemistry, 2022
The conversion of tetrazolo[1,5-a]quinoxalines to 1,2,3-triazoloquinoxalines and triazoloimidazoquinoxalines under typical conditions of a CuAAC reaction has been investigated.
Laura Holzhauer, Chloé Liagre, Olaf Fuhr, Nicole Jung, Stefan Bräse   +4 more
doaj   +1 more source

Imidazole Hybrids: A Privileged Class of Heterocycles in Medicinal Chemistry with New Insights into Anticancer Activity

Molecules
Imidazole is a five-membered heterocyclic system featuring two nitrogen heteroatoms at the 1- and 3-positions of the ring. The imidazole scaffold is particularly suited for kinase inhibition concepts.
Zarifa Murtazaeva, Azizbek Nasrullaev, Anvarjon Buronov, Shukhrat Gaybullaev, Lifei Nie, Sodik Numonov, Zohidjon Khushnazarov, Davron Turgunov, Rustamkhon Kuryazov, Jiangyu Zhao, Khurshed Bozorov   +10 more
doaj   +1 more source

Synthesis and crystal structures of two 1,3-di(alkyloxy)-2-(methylsulfanyl)imidazolium tetrafluoridoborates

Acta Crystallographica Section E: Crystallographic Communications, 2020
Two salts were prepared by methylation of the respective imidazoline-2-thione at the sulfur atom, using Meerwein's salt (trimethyloxonium tetrafluoridoborate) in CH2Cl2. 1,3-Dimethoxy-2-(methylsulfanyl)imidazolium tetrafluoridoborate (1), C6H11N2O2S+·BF4−
Thomas Gelbrich, Martin Lampl, Gerhard Laus, Volker Kahlenberg, Hubert Huppertz, Herwig Schottenberger   +5 more
doaj   +1 more source