Results 1 to 10 of about 334,731 (408)
Molecules, 2023 Imidazole was first synthesized by Heinrich Debus in 1858 and was obtained by the reaction of glyoxal and formaldehyde in ammonia, initially called glyoxaline.
Heber Victor Tolomeu +1 more
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Imidazole Hybrids: A Privileged Class of Heterocycles in Medicinal Chemistry with New Insights into Anticancer Activity [PDF]
MoleculesImidazole is a five-membered heterocyclic system featuring two nitrogen heteroatoms at the 1- and 3-positions of the ring. The imidazole scaffold is particularly suited for kinase inhibition concepts.
Zarifa Murtazaeva +10 more
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Aggregate, 2022 The development and enrichment of high‐performance organic fluorophores that simultaneously possess thermally activated delayed fluorescence (TADF) and aggregation‐induced emission (AIE) properties is going pursued but remains a great challenge due to ...
Ge Yang +5 more
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Proton transfer in histidine-tryptophan heterodimers embedded in helium droplets [PDF]
Journal of Chemical Physics 142, 114306 (2015), 2015 We used cold helium droplets as nano-scale reactors to form and ionize, by electron bombardment and charge transfer, aromatic amino acid heterodimers of histidine with tryptophan, methyl-tryptophan, and indole. The molecular interaction occurring through an N-H...N hydrogen bond leads to a proton transfer from the indole group of tryptophan to the ...
Bellina, Bruno +2 more
arxiv +3 more sources
Review of pharmacological effects of imidazole derivatives [PDF]
Ķazaķstannyṇ Klinikalyķ Medicinasy, 2022 Imidazole derivatives are the perspective class of drugs with a broad spectrum of application in medicine. Imidazole is a nitrogen-containing heterocyclic ring; it has two equivalent forms; hydrogen atom may be located on any of two nitrogen atoms ...
Daniya Serdaliyeva +5 more
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Imidazoles as Potential Anticancer Agents: An Update on Recent Studies
Molecules, 2021 Nitrogen-containing heterocyclic rings are common structural components of marketed drugs. Among these heterocycles, imidazole/fused imidazole rings are present in a wide range of bioactive compounds.
Pankaj Sharma +4 more
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Molecules, 2022 The acid dissociation constant of three benzimidazoles, namely 2,2′-bibenzo[d]imidazole, 2,5′-bibenzo[d]imidazole, and 5,5′-bibenzo[d]imidazole, have been investigated by means of density functional theory calculations in gas phase and in aqueous ...
Liudmil Antonov +2 more
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SN Applied Sciences, 2021 In this paper, four novel kinds of triazine-trione based tri-imidazole derivatives (IM-TT, 2MI-TT, 2EI-TT and EMI-TT) were synthesized through the addition reaction between triglycidyl isocyanurate (TGIC) and imidazole (IM), 2-methylimidazole (2MI), 2 ...
Xiaodong Wan +3 more
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Elucidating the proton transport pathways in liquid imidazole with first-principles molecular dynamics [PDF]
J. Phys. Chem. Lett. 11 (2020) 6156-6163, 2021 Imidazole is a promising anhydrous proton conductor with a high conductivity comparable to that of water at a similar temperature relative to its melting point. Previous theoretical studies of the mechanism of proton transport in imidazole have relied either on empirical models or on ab initio trajectories that have been too short to draw significant ...
arxiv +1 more source
Chemistry Proceedings, 2021 Imidazole derivatives are known for their varied biological applications, such as antibacterial, antifungal, antioxidant, antiviral, antiparasitic and anticancer compounds, among others. Therefore, numerous imidazole derivatives have been synthesized and
Nuna L. P. Ramos +3 more
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