Results 31 to 40 of about 334,731 (408)

One pot domino synthesis of polyvicinalamine monomers [PDF]

, 2010
On a genere de l'imidazole par une reaction de type domino in situ entre le glyoxal, le formaldehyde et deux unites d'ammoniac aqueux. L'addition de bicarbonate aqueux et d'un anhydride carboxylique ou d'un dicarbonate de dialkyle conduit a la formation ...
Kilic, Cem Burak, Kılıç, Cem Burak, Taralp, Alpay   +2 more
core   +4 more sources

Zur Temperaturabhängigkeit der pH-Abhängigkeit enzymatischer Modellreaktionen

CHIMIA, 1975
The temperature dependence of the pH-dependence of the hydrolysis of p-nitrophenylacetate catalyzed by 4(β-hydroxyethyl)-imidazole, imidazole-propionic acid, cis- and trans-urocanic acid, mercaptoethanole, cysteamine and mercaptomethyl-imidazole was ...
R. von Kleinsorge, H.G. Löffler, F. Schneider   +2 more
doaj   +1 more source

Solution-phase synthesis of pyrrole-imidazole polyamides [PDF]

, 2009
Pyrrole−imidazole polyamides are DNA-binding molecules that are programmable for a large repertoire of DNA sequences. Typical syntheses of this class of heterocyclic oligomers rely on solid-phase methods. Solid-phase methodologies offer rapid assembly on
Chenoweth, David M., Dervan, Peter B., Harki, Daniel A.   +2 more
core   +3 more sources

Nanoscale ATP-Responsive Zeolitic Imidazole Framework-90 as a General Platform for Cytosolic Protein Delivery and Genome Editing.

Journal of the American Chemical Society, 2019
Metal-organic frameworks (MOFs) are an emerging class of nanocarriers for drug delivery, owing to their tunable chemical functionality. Here we report ATP-responsive zeolitic imidazole framework-90 (ZIF-90) as a general platform for cytosolic protein ...
Xiaoti Yang, Qiao Tang, Ying Jiang, Meining Zhang, Ming Wang, L. Mao   +5 more
semanticscholar   +1 more source

6-(4-Fluorophenyl)-8-phenyl-2,3-dihydro-4H-imidazo[5,1-b][1,3]thiazin-4-one: an unusual [6-5] fused-ring system [PDF]

, 2007
The title compound, C₁₈H₁₃FN₂OS, is the first structural example of a [6-5] fused ring incorporating the 2,3-dihydro-4H-imidazo[5,1-b][1,3]thiazin-4-one molecular scaffold.
Coleman, Claire M., Gallagher, John F., Le Bas, Marie-Delphine H., O'Shea, Donal F.   +3 more
core   +1 more source

Epoxidation of Strained Alkenes Catalysed by (1,2-dimethyl-4(1H)pyridinone-3-olate)2MnIIICl [PDF]

, 2015
The mild epoxidation of strained alkenes using (DMPO)2MnCl catalyst (DMPO = 1,2-dimethyl-4(1H)-pyridinone-3-olate) in the presence of various oxidants was studied.
Robinson-Miller, Adam, Tetard, David, Wyatt, Mark   +2 more
core   +1 more source

Synthesis and Quantitative Structure–Activity Relationship of Imidazotetrazine Prodrugs with Activity Independent of O6-Methylguanine-DNA-methyltransferase, DNA Mismatch Repair and p53. [PDF]

, 2013
The antitumor prodrug Temozolomide is compromised by its dependence for activity on DNA mismatch repair (MMR) and the repair of the chemosensitive DNA lesion, O6-methylguanine (O6-MeG), by O6-methylguanine-DNA-methyltransferase (EC 2.1.1.63, MGMT). Tumor
Arris C. E., Arrowsmith J., Barvaux V. A., Boberg F., Boyd M. R., Bunz F., Damera K., Darkes M. J. M., De K., Denny B. J., Dimitrios Pletsas, Dinca E. B., Elrashied A. E. Garelnabi, Garelnabi E. A. E., Hirose Y., Honnalli S. S., Judson P. L., Karran P., Karran P., Kotera M., Leteurtre F., Li Li, Liu L., McElhinney R. S., McGarrity J. F., Mladek A. C., Nishizuka S., Pletsas D., Richard T. Wheelhouse, Roger M. Phillips, Sarkaria J. N., Schmidt B. F., Schmiedekamp A., Shealy Y. F., Siddiqui A. A., Smith R. H., Stevens M. F. G., Svilar D., Wang Y., Wheelhouse R. T., Wheelhouse R. T., Zhang J., Zhang J.   +42 more
core   +1 more source

Structural Basis for EGFR Mutant Inhibition by Trisubstituted Imidazole Inhibitors.

Journal of Medicinal Chemistry, 2020
Acquired drug resistance in epidermal growth factor receptor (EGFR) mutant non-small cell lung cancer is a persistent challenge in cancer therapy. Previous studies of trisubstituted imidazole inhibitors lead to the serendipitous discovery of inhibitors ...
D. Heppner, Marcel Günther, Florian Wittlinger, S. Laufer, M. Eck   +4 more
semanticscholar   +1 more source

Complexes of gold and imidazole formed in helium nanodroplets [PDF]

Phys. Chem. Chem. Phys., 2018, 20, 7739-7745, 2019
We have studied complexes of gold atoms and imidazole (C$_3$N$_2$H$_4$, abbreviated Im) produced in helium nanodroplets. Following the ionization of the doped droplets we detect a broad range of different Au$_m$Im$_n^+$ complexes, however we find that for specific values of $m$ certain $n$ are "magic" and thus particularly abundant.
arxiv   +1 more source

Self-Association of Organic Solutes in Solution: A NEXAFS Study of Aqueous Imidazole [PDF]

, 2015
N K-edge near-edge X-ray absorption fine-structure (NEXAFS) spectra of imidazole in concentrated aqueous solutions have been acquired. The NEXAFS spectra of the solution species differ significantly from those of imidazole monomers in the gas phase and ...
A. J. Scott, Alison, Apen, B. M. Sattelle, Bernstein, Bernstein, Blaha, Bonnett, C. R. Seabourne, Clark, Craven, Davey, Davey, Debenedetti, Domanska, E. F. Aziz, Edington, G. A. Hembury, Gao, Gao, Gebauer, Gontrani, Hunter, Hähner, Hückel, Hüfner, J. S. Stevens, Jagoda-Cwiklik, Jagoda-Cwiklik, Kashchiev, Kashchiev, Kolczewski, Liem, M. J. Thomason, Martinez, Monkhorst, Moreau, Niemantsverdriet, Nolting, Oxtoby, Pack, Pan, Peral, S. L. M. Schroeder, Schwarz, Seabourne, Shaik, Spitaleri, Stevens, Stevens, Stevens, Stevens, Stevens, Stevens, Stevens, Stevens, Stevens, Stöhr, Triguero, Triguero, Triguero, Triguero, Vekilov, Volmer, Vosko, Weissbuch, Will   +66 more
core   +2 more sources