Results 41 to 50 of about 4,157 (168)
AppliedChemImidazole dipeptides (IDPs), including carnosine, anserine, and balenine, are functional food ingredients found in meats. They have been reported to exhibit high antioxidant activity. 2-Oxo-imidazole dipeptides (2-oxo-IDPs) are present in trace amounts in various tissues and show notably higher antioxidant activity compared with IDPs.
Yasunari Yamada +8 more
openaire +1 more source
Allergy, Volume 81, Issue 6, Page 2036-2046, June 2026.Graphical The crystal structure of a major peanut allergen Ara h 2.0201 in a complex with a human‐derived IgE Fab fragment has been determined. The immunocomplex shows the trivalent binding of Fabs, creating a cross‐linked structure effective in the formation of large complexes on the surface of effector cells. Hydroxylation of proline has implications
Tarja Parkkinen +4 more
wiley +1 more source
, 2016 We report here the first example of peptide-functionalized gold nanoparticles hydrolytically active against carboxylate esters. The active units are constituted by His-Phe-OH terminating thiols.
Paolo Pengo (2529787) +3 more
core +1 more source
, 2020 © 2020 Informa UK Limited, trading as Taylor & Francis Group. The course of reactions between [Au(en)Cl2]+ (en is ethylenediamine) and [AuCl4]– complexes with an equimolar amount of X-L-His dipeptides (X = Gly, L-Ala and L-Ser) was investigated in ...
Andrejević L. +4 more
core +1 more source
Enzymatic Synthesis of Diverse Heterocycles by a Noncanonical Nonribosomal Peptide Synthetase
, 2021 Nonribosomal peptide synthetases (NRPSs) are typically multimodular enzymes that assemble amino acids or carboxylic acids into complex natural products.
Crawford, D.M. +9 more
core +2 more sources
Optimal 1TEL–target protein linker character is target protein‐dependent
Acta Crystallographica Section D, Volume 82, Issue 5, Page 516-532, May 2026.In this study, we examine the effect of short to medium‐length flexible, semi‐flexible and rigid linkers on the crystallization of a DARPin or the TNK1 UBA domain fused to the 1TEL protein crystallization chaperone, demonstrating that while rigid linkers can impair crystallization and reduce diffraction quality, the ideal linker character remains ...
Maria J. Pedroza Romo +22 more
wiley +1 more source
Thiazole- and imidazole-containing peptidomimetic inhibitors of protein farnesyltransferase
, 2011 Mimetics of the C-terminal CAAX tetrapeptide of Ras protein were designed replacing internal dipeptide AA with 4-amino-2-phenylbenzoic acid and cysteine (C) with 2-amino-4-thiazolyl-, 2-mercapto-4-thiazolyl-, 2-mercapto-4-imidazolyl- and 2-methylmercapto-
E. Valoti +18 more
core +1 more source
Microbial Biotechnology, Volume 19, Issue 5, May 2026.The orphan cytochrome P450 CYP107J1 with unknown redox partners was rationally modified into H2O2‐driven form. The QE (E251Q/T252E) mutant produced valuable chemicals by simply mixing the enzyme with substrate and H2O2. ABSTRACT Cytochrome P450 monooxygenases (P450s) not only play many physiological roles in oxidative metabolism but are also promising ...
Hideki Kato +5 more
wiley +1 more source
Reduced Muscular Carnosine in Proximal Myotonic Myopathy—A Pilot 1H‐MRS Study
Annals of Clinical and Translational Neurology, Volume 13, Issue 4, Page 788-795, April 2026.ABSTRACT Objective Myotonic dystrophy type 2 (proximal myotonic myopathy, PROMM) is a progressive multisystem disorder with muscular symptoms (proximal weakness, pain, myotonia) and systemic manifestations such as diabetes mellitus, cataracts, and cardiac arrhythmias.
Alexander Gussew +11 more
wiley +1 more source
Viability of Glioblastoma Cells and Fibroblasts in the Presence of Imidazole-Containing Compounds
The naturally occurring dipeptide carnosine (-alanyl-L-histidine) specifically attenuates tumor growth. Here, we ask whether other small imidazole-containing compounds also affect the viability of tumor cells without affecting non-malignant cells and ...
Oppermann, Henry +5 more
core +2 more sources