Results 41 to 50 of about 28,814 (216)

Human plasmacytoid dendritic cells and cutaneous melanoma [PDF]

, 2020
The prognosis of metastatic melanoma (MM) patients has remained poor for a long time. However, the recent introduction of effective target therapies (BRAF and MEK inhibitors for BRAFV600-mutated MM) and immunotherapies (anti-CTLA-4 and anti-PD-1) has ...
Bugatti, Mattia, Consoli, Francesca, Monti, Matilde, Vermi, William, Vescovi, Raffaella   +4 more
core   +2 more sources

Equine sarcoids: Bovine Papillomavirus type 1 transformed fibroblasts are sensitive to cisplatin and UVB induced apoptosis and show aberrant expression of p53 [PDF]

, 2012
Bovine papillomavirus type 1 infects not only cattle but also equids and is a causative factor in the pathogenesis of commonly occurring equine sarcoid tumours.
Campo, M., Finlay, M., Morgan, I.M., Nasir, L., Yuan, Z.   +4 more
core   +3 more sources

Impact of Age and Body Site on Adult Female Skin Surface pH [PDF]

, 2012
Background: pH is known as an important parameter in epidermal barrier function and homeostasis. Aim: The impact of age and body site on skin surface pH (pH(SS)) of women was evaluated in vivo.
Barbara Behm, Barland CO, Behne MJ, Behne MJ, Braun-Falco O, Choi EH, Dikstein S, Elias PM, Fluhr JW, Fluhr JW, Ghadially R, Ghadially R, Giusti F, Hachem JP, Hans Christian Korting, Hoeger PH, Kim EJ, Kocinkova AS, Korting HC, Korting HC, Kürner JM, Lambers H, Liebsch G, Mauro T, Michael Landthaler, Philipp Babilas, Posch HE, Robert Johannes Meier, Schmid-Wendtner MH, Schmuth M, Schreml S, Schreml S, Seyfarth F, Stephan Schreml, Takagi Y, Veronika Zeller, Wilhelm KP, Ye J, Yosipovitch G, Yosipovitch G, Zlotogorski A   +40 more
core   +2 more sources

8-Methoxypsoralen Plus Ultraviolet A Reduces the Psoriatic Response to Imiquimod in a Murine Model

Acta Dermato-Venereologica, 2018
The effects of 8-Methoxypsoralen plus ultraviolet A (PUVA) or ultraviolet B (UVB) alone on imiquimod-induced psoriasis were examined in a mouse model.
Nitesh Shirsath, Karin Wagner, Simone Tangermann, Michaela Schlederer, Christian Ringel, Lukas Kenner, Bernhard Brüne, Peter Wolf   +7 more
doaj   +1 more source

Ameliorating Effect of Oral Guggulsterone Administration in Imiquimod-Induced Psoriasis in Mice

Iraqi Journal of Pharmaceutical Sciences, 2018
Psoriasis is a common chronic skin condition characterized by infiltration of inflammatory cells into the epidermis and altered keratinocyte differentiation.
Raghad A. Khaleel, Munaf H. Zalzala
doaj   +1 more source

Liposomal Nanoconfinement Enables Type I Photodynamic Conversion for Synergistic Cancer Photothermal‐Immunotherapy

Advanced Science, EarlyView.
Liposomal nanoconfinement converts the hemicyanine photosensitizer RhM from Type‐II to Type‐I photodynamic therapy (PDT) while enhancing photothermal therapy (PTT). The RhM‐R837@Lip nanoassembly efficiently generates superoxide (O2•−) and hydroxyl radicals (•OH) to kill tumor cells and achieve tumor ablation.
Minglu Zhang, Shanshan Liang, Meng Wang, Tingfeng Zhang, Jinke Liu, Yuyuan Peng, Hao Fang, Lingna Zheng, Xiao He, Meng Wang, Luling Wu, Tony D. James, Wei Zhao, Bing Wang, Weiyue Feng   +14 more
wiley   +1 more source

Sirt3 Genetically Engineered Apoptotic Bodies Alleviate Skeletal Aging by Limiting Aggravated NLRP3 Inflammasome Activation of Senescent Macrophages

Advanced Science, EarlyView.
The senescence of macrophages leads to a decrease in the expression of Sirtuin3 (Sirt3), which in turn aggravates the NLRP3 inflammasome activation and IL‐1β secretion, thereby promoting the aging‐related osteoporosis. Sirt3‐enriched apoptotic bodies (ABs‐Sirt3) generated through genetic editing approaches can alleviate skeletal aging by targeting ...
Yanglin Wu, Shifeng Ling, Jiayi Mao, Hongyi Wang, Bo Wang, Zhenjia Che, Wenguo Cui, Ming Cai   +7 more
wiley   +1 more source

Engineered Bacteria Factory Integrating Drug Delivery and Antibody Manufacture for Activating the STING Signal Pathway Mediated Tumor Immunotherapy

Advanced Science, EarlyView.
To address the limitations of protein‐based ICIs in applications, this study constructed an engineered bacterium, HRB, capable of expressing aCD47 in hypoxic TME. Through the Schiff base reaction, responsive liposomes (LC) loaded with the STING agonist cGAMP were connected to the surface of bacteria to form HRB@LC.
Peng‐Shuo Dong, Tian Yao, Yong Li, Zi‐Hui Yan, Xiao‐Ting Xie, Jia‐Hua Zou, Kai Cheng, Jin‐Xuan Fan, Yuan‐Di Zhao, Qiu‐Ran Xu   +9 more
wiley   +1 more source

TOPical Imiquimod treatment of high-grade Cervical intraepithelial neoplasia (TOPIC trial): Study protocol for a randomized controlled trial [PDF]

, 2016
Background: Cervical intraepithelial neoplasia (CIN) is the premalignant condition of cervical cancer. Whereas not all high grade CIN lesions progress to cervical cancer, the natural history and risk of progression of individual lesions remain ...
Beekhuizen, H.J. (Heleen) van, Gerestein, C.G. (Kees), Gorp, T. (Toon) van, Hopman, A.H.N. (Anton), Koeneman, M.M. (Margot), Kooreman, L.F.S., Kruitwagen, R.F.M.P. (Roy), Kruse, A.J., Nijman, H.W. (Hans), Sep, S.J.S. (Simone), Slangen, A.H.L. (Arjen), van de Sande, M., Zur Hausen, A. (Axel)   +12 more
core   +5 more sources

Comprehensive, Multimodal Characterization of an Imiquimod-Induced Human Skin Inflammation Model for Drug Development [PDF]

, 2018
Imiquimod (IMQ) is often used as a topical challenge agent to provoke local skin inflammation. The objective of this study was to develop and refine a rapid, temporary, and reversible human skin inflammation model with IMQ for application in clinical ...
Beutner, Bieber, Boehncke, Burke-Gaffney, der Fits, Dickson, Fanti, Flutter, Garzorz-Stark, Gregorio, Hawkes, Mestas, Nestle, Nestle, Ottaviani, Pasmatzi, Pasparakis, Patel, Racz, Rajan, Schon, Seters, Smith, Ueyama, Vinter, Wu   +25 more
core   +9 more sources