Results 21 to 30 of about 322,455 (262)

Development of a Fast Onset Proton Pump Inhibitor: Comparison of Fixed-Dose Combination of Rabeprazole and Sodium Bicarbonate (YPI-011) to the Conventional Enteric-Coated Rabeprazole

Drug Design, Development and Therapy, 2023
Sungyeun Bae,1 Jihoon Kwon,2 Mi-Hye Lee,3 Kyung-Sang Yu,1 SeungHwan Lee1 1Department of Clinical Pharmacology and Therapeutics, Seoul National University College of Medicine and Hospital, Seoul, Republic of Korea; 2Department of Statistics, APACE, Seoul,
Bae S, Kwon J, Lee MH, Yu KS, Lee S
doaj  

Dual Release Paracetamol in Osteoarthritis of Knee: A Randomized Controlled Clinical Trial [PDF]

Journal of Clinical and Diagnostic Research, 2014
Background: Paracetamol is recommended as first line agent for pain management in osteoarthritis (OA) by various guidelines. The main problem associated with management of osteoarthritis is long term patient compliance to paracetamol due to its ...
Vishwnath Yaligod, D. Gokul Raj, Ateet B. Sharma, Mallikarjun Swami B., Sumit Batra, Apurv Acharya, Sanjay Kumar H. Mar, Ketan R. Patel, Vipul Prajapati   +8 more
doaj   +1 more source

DEVELOPMENT AND IN VITRO ASSESSMENT OF GASTRO-RETENTIVE BILAYER FLOATING TABLET FOR MANAGING HYPERTENSION IN ACUTE CONDITIONS [PDF]

Bulletin of Pharmaceutical Sciences. Assiut University
Background: This study disseminates the formulation and in vitro assessment of bilayer floating tablets designed to be retained in the stomach, delivering a combination of amlodipine besylate and atenolol.
Aparna Datta, Ambika Mandal, Debarpan Chatterjee, Sutapa Majee   +3 more
doaj   +1 more source

Formulation development and optimization of polyox based quick dissolving film of quetiapine

Journal of Pharmacy and Bioallied Sciences, 2012
Quick dissolving film prepared by various grades of polyox like Polyox N10,N80, N750 and N205. Polyox having excellent film forming capacity with rapid hydration power which leads to rapid disintegration of film upon contact with saliva.
A Sunita Chaudhary, B Ankit Chaudhary, A Tejal Mehta   +2 more
doaj   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source

Feasibility of Hot Melt Extrusion in Converting Water-Based Nanosuspensions into Solid Dosage Forms

Pharmaceutics
Aim: In addition to numerous benefits provided by nanosuspensions (NSs) (e.g., enhanced saturation solubility, increased area for interaction with fluids), they suffer from major stability, handling and compliance issues. To overcome these challenges, we
Erasmo Ragucci, Marco Uboldi, Adam Sobczuk, Giorgio Facchetti, Alice Melocchi, Mauro Serratoni, Lucia Zema   +6 more
doaj   +1 more source

Comparison of immediate release and extended release formulations in therapy

Psychiatry and Clinical Psychopharmacology, 2021
The pharmacokinetics of drugs determine some of the parameters such as the dosing frequency, the route of administration, starting dose , time to reach the steadystate concentration etc.
Yağız Üresin, Elif Baran
doaj  

Hot-Melt 3D Extrusion for the Fabrication of Customizable Modified-Release Solid Dosage Forms

Pharmaceutics, 2020
In this work, modified-release solid dosage forms were fabricated by adjusting geometrical properties of solid dosage forms through hot-melt 3D extrusion (3D HME).
Jaemin Lee, Chanwoo Song, Inhwan Noh, Sangbyeong Song, Yun-Seok Rhee   +4 more
doaj   +1 more source

The risk of developing motor complications with Levodopa immediate versus dual release upon treatment initiation in Parkinson’s disease

Clinical Parkinsonism & Related Disorders, 2023
Introduction: Motor complications (MCs) compromise therapy in many patients suffering from Parkinson’s Disease. By achieving more physiologic stimulation of dopamine-receptors, the continuous dopamine stimulation hypothesis suggests that longer-acting ...
Christian Ineichen, Heide Baumann-Vogel, Matthias Sitzler, Christian R. Baumann   +3 more
doaj   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source