Results 1 to 10 of about 1,650,706 (352)

Barriers to immune cell infiltration in tumors

Journal for ImmunoTherapy of Cancer, 2023
Increased immune cell infiltration into tumors is associated with improved patient survival and predicts response to immune therapies. Thus, identification of factors that determine the extent of immune infiltration is crucial, so that methods to ...
Craig L Slingluff, Marit M Melssen, Natasha D Sheybani, Katie M Leick   +3 more
doaj   +2 more sources

Pan-Cancer Analysis of Immune Cell Infiltration Identifies a Prognostic Immune-Cell Characteristic Score (ICCS) in Lung Adenocarcinoma

Frontiers in Immunology, 2020
Background: The tumor microenvironment (TME) consists of heterogeneous cell populations, including malignant cells and nonmalignant cells that support tumor proliferation, invasion, and metastasis through extensive cross talk.
Shuguang Zuo, Min Wei, Shiqun Wang, Jie Dong, Jiwu Wei, Jiwu Wei   +5 more
doaj   +2 more sources

SLC43A2-mediated immune cell infiltration: a potential therapeutic target in acute myeloid leukemia [PDF]

Frontiers in Immunology
BackgroundTumor cells compete with T cells for methionine by overexpressing SLC43A2 (solute carrier family 43 member 2), leading to T cell exhaustion. However, the correlation between SLC43A2 and immune infiltration or malignant features in acute myeloid
Mengnan Li, Tao Zhang, Bing Wang, Jile Liu, Mohan Zhao, Yanyu Jiang, Yu Zhang, Mingfeng Zhao   +7 more
doaj   +2 more sources

Integrated single cell and bulk sequencing analysis identifies tumor reactive CXCR6+ CD8 T cells as a predictor of immune infiltration and immunotherapy outcomes in hepatocellular carcinoma

Frontiers in Oncology, 2023
BackgroundVarious immune cell types in the tumor microenvironment (TME) of hepatocellular carcinoma (HCC) have been identified as important parameters associated with prognosis and responsiveness to immunotherapy.
Xiaogang Li, Xiaogang Li, Zheng Gao, Zheng Gao, Jiafeng Chen, Jiafeng Chen, Shanru Feng, Shanru Feng, Xuanming Luo, Yinghong Shi, Yinghong Shi, Zheng Tang, Zheng Tang, Weiren Liu, Weiren Liu, Xin Zhang, Xin Zhang, Ao Huang, Ao Huang, Qiang Gao, Qiang Gao, Aiwu Ke, Aiwu Ke, Jian Zhou, Jian Zhou, Jian Zhou, Jia Fan, Jia Fan, Xiutao Fu, Xiutao Fu, Zhenbin Ding, Zhenbin Ding, Zhenbin Ding   +32 more
doaj   +1 more source

Development of an Immune-Related Gene Signature for Prognosis in Melanoma

Frontiers in Oncology, 2021
Melanoma remains a potentially deadly malignant tumor. The incidence of melanoma continues to rise. Immunotherapy has become a new treatment method and is widely used in a variety of tumors. Original melanoma data were downloaded from TCGA.
Jia-An Zhang, Xu-Yue Zhou, Dan Huang, Chao Luan, Heng Gu, Mei Ju, Kun Chen   +6 more
doaj   +1 more source

Analysis and validation of diagnostic biomarkers and immune cell infiltration characteristics in pediatric sepsis by integrating bioinformatics and machine learning

World Journal of Pediatrics, 2023
Background Pediatric sepsis is a complicated condition characterized by life-threatening organ failure resulting from a dysregulated host response to infection in children.
Wen-Yuan Zhang, Zhong-Hua Chen, Xiao-xia An, Hui Li, Hua-Lin Zhang, Shui-jing Wu, Yu-Qian Guo, Kai Zhang, Cong-Li Zeng, X. Fang   +9 more
semanticscholar   +1 more source

KIF2C is a prognostic biomarker associated with immune cell infiltration in breast cancer

BMC Cancer, 2023
Background The kinesin-13 family member 2C (KIF2C) is a versatile protein participating in many biological processes. KIF2C is frequently up-regulated in multiple types of cancer and is associated with cancer development.
Shanshan Liu, Zi-Yi Ye, V. Xue, Qi Sun, Huanhuan Li, D. Lu   +5 more
semanticscholar   +1 more source

Combined PD-1/PD-L1 and tumor-infiltrating immune cells redefined a unique molecular subtype of high-grade serous ovarian carcinoma

BMC Genomics, 2022
Background High-grade serous ovarian carcinoma is highly heterogeneous, and although many studies have been conducted to identify high-grade serous ovarian carcinoma molecular subtypes that are sensitive to immunotherapy, no precise molecular subtype has
Ping Liu, Ruoxu Chen, Xudong Zhang, Ruiting Fu, Lin Tao, Wei Jia   +5 more
doaj   +1 more source

Opposing roles by KRAS and BRAF mutation on immune cell infiltration in colorectal cancer – possible implications for immunotherapy

British Journal of Cancer, 2023
Background The immune response has important clinical value in colorectal cancer (CRC) in both prognosis and response to immunotherapy. This study aims to explore tumour immune cell infiltration in relation to clinically well-established molecular ...
S. Edin, B. Gylling, Xingru Li, Åsa Stenberg, Anna Löfgren-Burström, C. Zingmark, B. van Guelpen, I. Ljuslinder, Agnes Ling, R. Palmqvist   +9 more
semanticscholar   +1 more source

Identification of diagnostic biomarks and immune cell infiltration in ulcerative colitis

Scientific Reports, 2023
We aimed to explore diagnostic biomarks and immune cell infiltration characteristics in ulcerative colitis (UC). We used the dataset GSE38713 as the training set and dataset GSE94648 as the test set.
Qin Chen, Shaosheng Bei, Zhiyun Zhang, Xiaofeng Wang, Yunying Zhu   +4 more
semanticscholar   +1 more source