Results 11 to 20 of about 6,519,090 (301)

TERT promoter methylation predicts overall survival, immune cell infiltration and response to immunotherapy in clear cell renal cell carcinoma

Clinical Epigenetics
Purpose Telomerase reverse transcriptase (TERT) is one of the most well-established oncogenes in tumor development and progression. It is widely known that TERT promoter hypermethylation is associated with its transcription activation.
Xinyu Guan, Jiahao Meng, Wenjun Yi, Kun Ye, Hongyu Gao, Yue Hong, Limeng Qu, Shirong Ding, Qian Long   +8 more
doaj   +2 more sources

Supplementary Data from Quantification of T- and B-cell Immune Receptor Distribution Diversity Characterizes Immune Cell Infiltration and Lymphocyte Heterogeneity in Clear Cell Renal Cell Carcinoma

, 2022
Supplementary Data from Quantification of T- and B-cell Immune Receptor Distribution Diversity Characterizes Immune Cell Infiltration and Lymphocyte Heterogeneity in Clear Cell Renal Cell ...
Esther N. Katende (14954416), Philipp M. Altrock (10329119), Anders Berglund (14954401), George Blanck (735281), Boris I. Chobrutskiy (5986322), Jasreman Dhillon (183985), Meghan C. Ferrall-Fairbanks (14954398), Nicholas H. Chakiryan (10681431), Brandon J. Manley (14954419), Jamie K. Teer (14932607), James J. Mulé (14954404), Youngchul Kim (9092151), Juan F. Arturo (14954413), Erin M. Siegel (14954407), Seyed Shayan A. Falasiri (14954410), Michelle Fournier (685123)   +15 more
core   +5 more sources

Immune infiltrating cells in duodenal cancers [PDF]

Journal of Translational Medicine, 2020
Abstract Background Duodenal adenocarcinoma (DA) is a rare yet aggressive malignancy, with increasing incidence in the last decades. Its low frequency has hampered a thorough understanding of the pathogenesis of the disease and of its biology, limiting the identification of tailored therapeutic options.
Donisi, G., Capretti, G., Cortese, N., Rigamonti, A., Gavazzi, F., Nappo, G., Pulvirenti A, Sollai, M., Spaggiari, P., Zerbi, A., Marchesi, F   +20 more
openaire   +3 more sources

DFNA5 regulates immune cells infiltration and exhaustion [PDF]

Cancer Cell International, 2022
Abstract Background DFNA5 (GSDME) belongs to Gasdermin familily that is involved in a variety of cancers and triggers cell pyroptosis after chemical treatment. However, the relationship in DFNA5 between prognosis and immune cells in diverse cancers has been receiving little attention.
Jian Hu, Wenceng Pei, Minren Jiang, Ying Huang, Fuyun Dong, Zhenyou Jiang, Ying Xu, Zihuang Li   +7 more
openaire   +3 more sources

Immune Cell Infiltrate and Prognosis in Gastric Cancer [PDF]

Cancers, 2020
Purpose: To examine and compare the prognostic value of immune cell score (ICS) and Klintrup–Mäkinen (KM) grade in gastric cancer. Methods: Gastric adenocarcinoma tissues from samples of 741 patients surgically treated in two hospitals in Finland were assessed for ICS and KM grade.
Niko Kemi, Niko Hiltunen, Juha P. Väyrynen, Vesa-Matti Pohjanen, Olli Helminen, Anna Junttila, Johanna Mrena, Jan Böhm, Heikki Huhta, Joni Leppänen, Tuomo J. Karttunen, Joonas H. Kauppila   +11 more
openaire   +3 more sources

Cdx2 regulates immune cell infiltration in the intestine [PDF]

Scientific Reports, 2021
AbstractThe intestinal epithelium is a unique tissue, serving both as a barrier against pathogens and to conduct the end digestion and adsorption of nutrients. As regards the former, the intestinal epithelium contains a diverse repertoire of immune cells, including a variety of resident lymphocytes, macrophages and dendritic cells.
Simon Chewchuk, Sanzida Jahan, David Lohnes   +2 more
openaire   +3 more sources

Immune infiltration in renal cell carcinoma [PDF]

Cancer Science, 2019
Immune infiltration of tumors is closely associated with clinical outcome in renal cell carcinoma (RCC). Tumor‐infiltrating immune cells (TIICs) regulate cancer progression and are appealing therapeutic targets. The purpose of this study was to determine the composition of TIICs in RCC and further reveal the independent prognostic values of TIICs ...
Shichao Zhang, Erdong Zhang, Jinhua Long, Zuquan Hu, Jian Peng, Lina Liu, Fuzhou Tang, Long Li, Yan Ouyang, Zhu Zeng   +9 more
openaire   +2 more sources

Infiltration of tumor spheroids by activated immune cells

Physical Biology, 2022
Abstract Recent years have seen a tremendous growth of interest in understanding the role that the adaptive immune system could play in interdicting tumor progression. In this context, it has been shown that the density of adaptive immune cells inside a solid tumor serves as a favorable prognostic marker across different types of ...
Mrinmoy Mukherjee, Oleksandr Chepizhko, Maria Chiara Lionetti, Stefano Zapperi, Caterina A. M. La Porta, Herbert Levine   +5 more
openaire   +4 more sources

Supplementary Figure from Cancer-Associated Fibroblasts Suppress CD8⁺ T-cell Infiltration and Confer Resistance to Immune-Checkpoint Blockade

, 2022
Supplementary Figure from Cancer-Associated Fibroblasts Suppress CD8+ T-cell Infiltration and Confer Resistance to Immune-Checkpoint ...
Syed Haider, Marjan Iravani (14957154), Syed Haider (3408887), Adam Mills, Ute Jungwirth (14957148), James Harper (3062097), Marjan Iravani, Liam Jenkins (14957145), Liam Jenkins, Adam Mills (14957157), Alexandra Avgustinova (14957151), Alexandra Avgustinova, Clare M. Isacke (14957160), James Harper, Clare M. Isacke, Ute Jungwirth   +15 more
core   +6 more sources

TIMER2.0 for analysis of tumor-infiltrating immune cells [PDF]

Nucleic Acids Research, 2020
Abstract Tumor progression and the efficacy of immunotherapy are strongly influenced by the composition and abundance of immune cells in the tumor microenvironment. Due to the limitations of direct measurement methods, computational algorithms are often used to infer immune cell composition from bulk tumor transcriptome profiles.
Taiwen Li, Jingxin Fu, Zexian Zeng, David Cohen, Jing Li, Qianming Chen, Bo Li, Xiaole Shirley Liu   +7 more
openaire   +2 more sources