Results 31 to 40 of about 614,807 (307)

PNOC Expressed by B Cells in Cholangiocarcinoma Was Survival Related and LAIR2 Could Be a T Cell Exhaustion Biomarker in Tumor Microenvironment: Characterization of Immune Microenvironment Combining Single-Cell and Bulk Sequencing Technology

Frontiers in Immunology, 2021
BackgroundCholangiocarcinoma was a highly malignant liver cancer with poor prognosis, and immune infiltration status was considered an important factor in response to immunotherapy.
Zheng Chen, Mincheng Yu, Jiuliang Yan, Lei Guo, Bo Zhang, Shuang Liu, Jin Lei, Wentao Zhang, Binghai Zhou, Jie Gao, Zhangfu Yang, Xiaoqiang Li, Jian Zhou, Jia Fan, Qinghai Ye, Hui Li, Yongfeng Xu, Yongsheng Xiao   +17 more
doaj   +1 more source

Tumor Immunometabolism Characterization in Ovarian Cancer With Prognostic and Therapeutic Implications

Frontiers in Oncology, 2021
Metabolic dysregulation in the tumor microenvironment has significant impact on immune infiltration and immune responses. However, interaction between immunity and metabolism in the ovarian microenvironment requires further exploration. We constructed an
Miner Yang, Gaowen Chen, Kunjie Gao, Yifeng Wang   +3 more
doaj   +1 more source

Distribution of Tumor-Infiltrating Immune Cells in Glioblastoma [PDF]

CNS Oncology, 2018
Evaluation of features related to infiltrating immune cell level in glioblastoma.Tumor-infiltrating lymphocytes (TILs) through H&E staining, and TILs (CD3, CD4, CD8 and CD20) and macrophage (CD68 and CD163) levels through immunohistochemistry were evaluated through digital analysis.CD68 (9.1%), CD163 (2.2%), CD3 (1.6%) and CD8 (1.6%) had the highest ...
Enrique Orrego, Carlos A Castaneda, Miluska Castillo, Luis A Bernabe, Sandro Casavilca, Arnab Chakravarti, Wei Meng, Pamela Garcia-Corrochano, Maria R Villa-Robles, Rocio Zevallos, Omar Mejia, Pedro Deza, Carolina Belmar-Lopez, Luis Ojeda   +13 more
openaire   +3 more sources

TLR7-mediated skin inflammation remotely triggers chemokine expression and leukocyte accumulation in the brain [PDF]

, 2016
Background: The relationship between the brain and the immune system has become increasingly topical as, although it is immune-specialised, the CNS is not free from the influences of the immune system.
A Boivin, A Constant, A Walter, AD Bachstetter, Alison McColl, B Winner, BT Fife, C Callewaere, C D'Mello, C Gemma, CA Thomson, Carolyn A. Thomson, CP Marques, CS McKimmie, CT Ekdahl, D Michlmayr, D Michlmayr, EE Ubogu, G Banisadr, G Banisadr, Gerard J. Graham, JH Dufour, JL Teeling, Jonathan Cavanagh, JS Cameron, JS Snyder, JT Rogers, L Azzi, L Cartier, L Fits van der, Louis Nerurkar, M Baggiolini, M Udina, ML Monje, MM Lee, N Andrews, Q Liu, R Dantzer, R Deacon, R Krishnan, R Rola, RM Deacon, RM Ransohoff, S Baraldi, S Goethals, S Potvin, S Tyring, SM O'Brien, U Patel, U Puntener, W Huang da, W Huang da, W Rostene, WJ Karpus   +53 more
core   +2 more sources

Immune signature of tumor infiltrating immune cells in renal cancer [PDF]

OncoImmunology, 2015
Tumor-associated immune cells have been discussed as an essential factor for the prediction of the outcome of tumor patients. Lymphocyte-specific genes are associated with a favorable prognosis in colorectal cancer but with poor survival in renal cell carcinoma (RCC).
Katharina, Geissler, Paolo, Fornara, Christine, Lautenschläger, Hans-Jürgen, Holzhausen, Barbara, Seliger, Dagmar, Riemann   +5 more
openaire   +2 more sources

Construction and validation of an immune infiltration-related risk model for predicting prognosis and immunotherapy response in low grade glioma

BMC Cancer, 2023
Background Low grade glioma (LGG) is considered a heterogeneous tumor with highly variable survival and limited efficacy of immunotherapy. To identify high-risk subsets and apply immunotherapy effectively in LGG, the status and function of immune ...
Jinna Li, Qing Guo, Rui Xing
doaj   +1 more source

PD-L1 blockade enhances response of pancreatic ductal adenocarcinoma to radiotherapy [PDF]

, 2017
Pancreatic ductal adenocarcinoma (PDAC) is considered a non‐immunogenic tumor, and immune checkpoint inhibitor monotherapy lacks efficacy in this disease. Radiotherapy (RT) can stimulate the immune system.
Azad, Abul, D'Costa, Zenobia, Diana, Angela, Dushek, Omer, Fokas, Emmanouil, Jones, Keaton, Kruger, Philipp, Liu, Stanley, McKenna, W. Gillies, Muschel, Ruth J., Sansom, Owen J., Yin Lim, Su   +11 more
core   +1 more source

Identification and Validation of Immune Infiltration Phenotypes in Laryngeal Squamous Cell Carcinoma by Integrative Multi-Omics Analysis

Frontiers in Immunology, 2022
BackgroundLaryngeal squamous cell carcinoma (LSCC) is one of the world’s most common head and neck cancer. However, the immune infiltration phenotypes of LSCC have not been well investigated.MethodsThe multi-omics data of LSCC were obtained from the TCGA
Li Yan, Xiaole Song, Gang Yang, Lifen Zou, Yi Zhu, Xiaoshen Wang   +5 more
doaj   +1 more source

Siah2 control of T-regulatory cells limits anti-tumor immunity. [PDF]

, 2020
Understanding the mechanisms underlying anti-tumor immunity is pivotal for improving immune-based cancer therapies. Here, we report that growth of BRAF-mutant melanoma cells is inhibited, up to complete rejection, in Siah2-/- mice.
Aifantis, Ioannis, Bosenberg, Marcus, Bradley, Linda M, Brown, Kevin, Dolgalev, Igor, Feng, Yongmei, Hockemeyer, Kathryn, Li, Yan, Marine, Jean-Christophe, Otero, Dennis C, Poźniak, Joanna, Rambow, Florian, Ronai, Ze'ev A, Scortegagna, Marzia, Tinoco, Roberto, Zhang, Tongwu   +15 more
core   +2 more sources

Single-cell transcriptomics reveals immune infiltrate in sepsis

Frontiers in Pharmacology, 2023
Immune cells and immune microenvironment play important in the evolution of sepsis. This study aimed to explore hub genes related to the abundance of immune cell infiltration in sepsis. The GEOquery package is used to download and organize data from the GEO database.
Xusheng Tu, He Huang, Shilei Xu, Caifei Li, Shaoning Luo   +4 more
openaire   +3 more sources