Results 51 to 60 of about 614,807 (307)

The parasitic worm-derived immunomodulator, ES-62 and its drug-like small molecule analogues exhibit therapeutic potential in a model of chronic asthma [PDF]

, 2016
Chronic asthma is associated with persistent lung inflammation and long-term remodelling of the airways that have proved refractory to conventional treatments such as steroids, despite their efficacy in controlling acute airway contraction and bronchial ...
Al-Riyami, L., Coltherd, J. C., Harnett, M. M., Harnett, W., Lawrie, R. E., Rodgers, D. T., Suckling, C. J.   +6 more
core   +1 more source

A Transendothelial Leukocyte Transmigration Model Based on Computational Fluid Dynamics and BP Neural Network

Frontiers in Bioengineering and Biotechnology, 2022
The mechanism of immune infiltration involving immune cells is closely related to various diseases. A key issue in immune infiltration is the transendothelial transmigration of leukocytes.
Qingjia Chi, Zichang Yang, Hua-Ping Liang   +2 more
doaj   +1 more source

B Cells Regulate Neutrophilia during Mycobacterium tuberculosis Infection and BCG Vaccination by Modulating the Interleukin-17 Response [PDF]

, 2013
We have previously demonstrated that B cells can shape the immune response to Mycobacterium tuberculosis, including the level of neutrophil infiltration and granulomatous inflammation at the site of infection. The present study examined the mechanisms by
A Casadevall, A Cruz, A Glatman-Freedman, AM Cooper, AR Martineau, B Nandi, C Diveu, C Keller, CE Sutton, CG Feng, Christopher M. Sassetti, CJ Thalhofer, CY Hu, D Kitamura, DB Rawool, DJ Cua, DV Jovanovic, E Lockhart, E Marino, E Roy, E Torrado, EB Eruslanov, FE Lund, FL Ribeiro-Gomes, J Hinchey, J Pedrosa, Jiayong Xu, JL Flynn, JM Daley, Joanne L. Flynn, John Chan, JS Thorson, JU Igietseme, K Dunussi-Joannopoulos, K Hamel, KA Sweeney, Kyri Dunussi-Joannopoulos, L Desvignes, L Li, Lee Kozakiewicz, LJ Brady, M Cella, M Laan, M Zhang, MC Tsai, ML Michel, NK Damle, P Miossec, P Seiler, P Ye, PJ Maglione, PJ Maglione, PJ Maglione, PR Hamann, PS Redford, Qinglin Ou, R Appelberg, R Blomgran, R Gopal, RJ North, SA Fulton, SA Khader, ST Passos, Steven A. Porcelli, T Eddens, T Hamilton, T Korn, T Matsushita, TK Kondratieva, W Ouyang, William R. Jacobs, X Zhang, Y Ito, Yanhua Wang, Yong Chen   +74 more
core   +3 more sources

Identification of testicular cancer immune infiltrates and novel immune cell subtypes

FEBS Open Bio, 2023
Testicular germ cell tumors (TGCT) are the most common type of testicular cancer, comprising 90–95% of cases and representing the most prevalent solid malignancy in young adult men. Immune infiltrates play important regulatory roles in tumors, but their role in TGCT remains unclear.
Zhiguo Zhu, Xujun Xuan, Xinkun Wang, Miaomiao Wang, Chunyang Meng, Zhonghai Li   +5 more
openaire   +3 more sources

Tumor-Infiltrating Immune Cells in Colorectal Cancer [PDF]

Neoplasia
Colorectal cancer encompasses a heterogeneous group of malignancies that differ in pathophysiological mechanisms, immune response and infiltration, therapeutic response, and clinical prognosis. Numerous studies have highlighted the clinical relevance of tumor-infiltrating immune cells among different types of colorectal tumors yet vary in cell type ...
Sonia A.M. Ferkel, Elizabeth A. Holman, Raoul S. Sojwal, Samuel J.S. Rubin, Stephan Rogalla   +4 more
openaire   +4 more sources

Immune Characteristics in Biliary Atresia Based on Immune Genes and Immune Cell Infiltration

Frontiers in Pediatrics, 2022
BackgroundBiliary atresia (BA) is a serious biliary disease in infancy. Jaundice is the most visual and prominent symptom, and it mainly involves bile duct cells leading to the loss of intrahepatic and extrahepatic bile ducts. If left untreated, it will eventually progress to liver cirrhosis. The pathogenesis of BA is not clear, and it is now generally
Chenyu Yang, Chenyu Yang, Huiwu Xing, Huiwu Xing, Bingqian Tan, Bingqian Tan, Mingman Zhang, Mingman Zhang   +7 more
openaire   +3 more sources

Quantifying tumor-infiltrating immune cells from transcriptomics data [PDF]

Cancer Immunology, Immunotherapy, 2018
By exerting pro- and anti-tumorigenic actions, tumor-infiltrating immune cells can profoundly influence tumor progression, as well as the success of anti-cancer therapies. Therefore, the quantification of tumor-infiltrating immune cells holds the promise to unveil the multi-faceted role of the immune system in human cancers and its involvement in tumor
Francesca Finotello, Zlatko Trajanoski
openaire   +2 more sources

RNF8 enhances the sensitivity of PD-L1 inhibitor against melanoma through ubiquitination of galectin-3 in stroma

Cell Death Discovery, 2023
The failure of melanoma immunotherapy can be mediated by immunosuppression in the tumor microenvironment (TME), and insufficient activation of effector T cells against the tumor.
Yanan Guo, Rong Shen, Keren Yang, Yutong Wang, Haoyun Song, Xiangwen Liu, Xin Cheng, Rile Wu, Yanfeng Song, Degui Wang   +9 more
doaj   +1 more source

Immune Cell Infiltration in Bladder Cancer [PDF]

, 2019
Abstract Background Bladder cancer is one of the most common malignant diseases with high recurrence rates worldwide. Although immunotherapy has been applied in bladder cancer for a long period of time, the tumor-infiltrating immune cells (TIICs) in bladder cancer has not been systematical investigated.
shanhui liu, Lanlan Li, Shan Wu, Wei He, Jianzhong Lu, Yan Tao, Jing Zhang, Shengjun Fu, Zhiping Wang   +8 more
openaire   +1 more source

Cuproptosis regulator-mediated patterns associated with immune infiltration features and construction of cuproptosis-related signatures to guide immunotherapy

Frontiers in Immunology, 2022
BackgroundLiver hepatocellular carcinoma (HCC) is a prevalent cancer that lacks a sufficiently efficient approach to guide immunotherapy. Additionally, cuproptosis is a recently identified regulated cell death program that is triggered by copper ...
Gongjun Wang, Gongjun Wang, Ruoxi Xiao, Shufen Zhao, Libin Sun, Jing Guo, Wenqian Li, Yuqi Zhang, Xiaoqian Bian, Wensheng Qiu, Shasha Wang   +10 more
doaj   +1 more source