Results 61 to 70 of about 614,807 (307)

Tumor immune infiltration estimated from gene expression profiles predicts colorectal cancer relapse

OncoImmunology, 2021
A substantial fraction of patients with stage I–III colorectal adenocarcinoma (CRC) experience disease relapse after surgery with curative intent. However, biomarkers for predicting the likelihood of CRC relapse have not been fully explored.
Yasmin Kamal, Dennis Dwan, Hannah J. Hoehn, Rebeca Sanz-Pamplona, M. Henar Alonso, Victor Moreno, Chao Cheng, Michael J. Schell, Youngchul Kim, Seth I. Felder, Hedy S. Rennert, Marilena Melas, Charalampos Lazaris, Joseph D. Bonner, Erin M. Siegel, David Shibata, Gad Rennert, Stephen B. Gruber, H. Robert Frost, Christopher I. Amos, Stephanie L. Schmit   +20 more
doaj   +1 more source

The immune phenotypes and different immune escape mechanisms in colorectal cancer

Frontiers in Immunology, 2022
The tumor microenvironment (TME) plays a crucial role in tumor progression and metastasis. However, the immune phenotypes of colorectal cancer (CRC) and the underlying immune escape mechanism have not been studied sufficiently.
Yihao Mao, Yuqiu Xu, Jiang Chang, Wenju Chang, Wenju Chang, Yang Lv, Peng Zheng, Zhiyuan Zhang, Zhiqiang Li, Qi Lin, Qi Lin, Wentao Tang, Wentao Tang, Dexiang Zhu, Dexiang Zhu, Meiling Ji, Meiling Ji, Guodong He, Guodong He, Qingyang Feng, Qingyang Feng, Jianmin Xu, Jianmin Xu   +22 more
doaj   +1 more source

Computational immune profiling in lung adenocarcinoma reveals reproducible prognostic associations with implications for immunotherapy

OncoImmunology, 2018
Non-small cell lung cancer is one of the leading causes of cancer-related death in the world. Lung adenocarcinoma, the most common type of non-small cell lung cancer, has been well characterized as having a dense lymphocytic infiltrate, suggesting that ...
Frederick S. Varn, Laura J. Tafe, Christopher I. Amos, Chao Cheng   +3 more
doaj   +1 more source

Immunonutrition before esophagectomy: Impact on immune surveillance mechanisms [PDF]

, 2017
Preoperative oral immunonutrition was demonstrated to improve immune response and to decrease the infection rate in patients with cancer. This study aimed to assess how immunonutrition could influence the immune cell response in the mucosal ...
Agostini, Marco, Alfieri, Rita, Cagol, Matteo, Castagliuolo, Ignazio, Castoro, Carlo, Cavallin, Francesco, Fassan, Matteo, Kotsafti, Andromachi, Nardi, Teresa, Pinto, Eleonora, Rugge, Massimo, Scarpa, Marco, Scarpa, Melania   +12 more
core   +1 more source

Human plasmacytoid dendritic cells and cutaneous melanoma [PDF]

, 2020
The prognosis of metastatic melanoma (MM) patients has remained poor for a long time. However, the recent introduction of effective target therapies (BRAF and MEK inhibitors for BRAFV600-mutated MM) and immunotherapies (anti-CTLA-4 and anti-PD-1) has ...
Bugatti, Mattia, Consoli, Francesca, Monti, Matilde, Vermi, William, Vescovi, Raffaella   +4 more
core   +2 more sources

Estrogen treatment decreases matrix metalloproteinase (MMP)-9 in autoimmune demyelinating disease through estrogen receptor alpha (ERalpha). [PDF]

, 2009
Matrix metalloproteinases (MMPs) have a crucial function in migration of inflammatory cells into the central nervous system (CNS). Levels of MMP-9 are elevated in multiple sclerosis (MS) and predict the occurrence of new active lesions on magnetic ...
Du, Sienmi, Gold, Stefan M, Morales, Laurie B, Sasidhar, Manda V, Sicotte, Nancy L, Tiwari-Woodruff, Seema K, Voskuhl, Rhonda R   +6 more
core   +3 more sources

Novel immune cell infiltration-related biomarkers in atherosclerosis diagnosis

PeerJ, 2023
Background Immune cell infiltration (ICI) has a close relationship with the progression of atherosclerosis (AS). Therefore, the current study was aimed to explore the role of genes related to ICI and to investigate potential mechanisms in AS. Methods
Ruoyu Dong, Jikuan Li, Guangwei Jiang, Ning Han, Yaochao Zhang, Xiaoming Shi   +5 more
openaire   +3 more sources

Characterizing the Tumor Microenvironment and Its Prognostic Impact in Breast Cancer

Cells
The tumor microenvironment (TME) is crucial in cancer development and therapeutic response. Immunotherapy is increasingly recognized as a critical component of cancer treatment.
Wenjuan Zhang, Alex Lee, Amit K. Tiwari, Mary Qu Yang   +3 more
doaj   +1 more source

Molecular profiling of resident and infiltrating mononuclear phagocytes during rapid adult retinal degeneration using single-cell RNA sequencing. [PDF]

, 2019
Neuroinflammation commonly accompanies neurodegeneration, but the specific roles of resident and infiltrating immune cells during degeneration remains controversial.
Burns, Marie E, Karlen, Sarah J, Miller, Eric B, Ronning, Kaitryn E   +3 more
core   +2 more sources

HK3 stimulates immune cell infiltration to promote glioma deterioration

Cancer Cell International, 2023
Abstract Background Glioma is the most common and lethal type of brain tumor, and it is characterized by unfavorable prognosis and high recurrence rates. The reprogramming of energy metabolism and an immunosuppressive tumor microenvironment (TME) are two hallmarks of tumors.
Shupeng Li, Ziwei Li, Xinyu Wang, Junzhe Zhong, Daohan Yu, Hao Chen, Wenbin Ma, Lingling Liu, Minghuang Ye, Ruofei Shen, Chuanlu Jiang, Xiangqi Meng, Jinquan Cai   +12 more
openaire   +3 more sources