Results 181 to 190 of about 2,266,569 (385)

1277 Unique microbial signatures are associated with clinical outcomes of metastatic melanoma after immune checkpoint blockade (ICI) therapy [PDF]

Aravind Sreeram, Charlotte E. Ariyan, Edmund K. Bartlett, Mary S. Brady, Michael A. Postow, Parisa Momtaz, James W. Smithy, Alexander N. Shoushtari, Danielle M. Bello, Chad Vanderbilt   +9 more
openalex   +1 more source

Bioengineered Pancreatic Cancer Immunosuppressive Microenvironment Models for Screening Immunotherapies

Advanced Healthcare Materials, EarlyView.
Bioengineering tumor‐stroma pancreatic cancer models with potential to emulate the native immunosuppressive tumor microenvironment. Cancer‐on‐a‐bead models exhibited higher relevance for screening immunotherapies and modulating the protumoral PDAC microenvironment. ABSTRACT Pancreatic cancer is notably resistant to treatment, primarily due to its dense
Maria V. Monteiro, Margarida Henriques‐Pereira, Bruno M. Neves, Vítor M. Gaspar, João F. Mano   +4 more
wiley   +1 more source

Endocrine toxicities of immune checkpoint inhibitors

Nature Reviews Endocrinology, 2021
Jordan J. Wright, A. Powers, Douglas B. Johnson   +2 more
semanticscholar   +1 more source

Triazine‐Trione Thermosets with High Processability for Scaffold Applications in Bone Tissue Engineering

Advanced Healthcare Materials, EarlyView.
Novel photo‐clickable triazine‐trione thermosets can be shaped and cured under mild conditions, including room and physiological temperatures. These materials are biocompatible and support osteogenic differentiation of bone marrow–derived mesenchymal stem cells on their surface.
Åshild Johansen, Shuntaro Yamada, Daniel J. Hutchinson, Mohammed A. Yassin, Samih Mohamed‐Ahmed, Cecilie Gjerde, Michael Malkoch, Kamal Mustafa   +7 more
wiley   +1 more source

Tumor-draining lymph nodes respond to immune checkpoint inhibition and orchestrate tumor immune remodeling

Cancer Immunology, Immunotherapy
Background Immune checkpoint inhibitors have traditionally been understood to exert their effects primarily within the tumor microenvironment, particularly targeting CD8 + T cells. However, recent studies have highlighted a pivotal role of tumor-draining
Jinzhu Zhang, Jian Ma, Yaru Niu, Jialiang Liu, Zhexue Wang, Jinyuan Guo, Yongsheng Meng, Ruifang Sun, Zhen Zhang, Haiyi Liu, Juan Xu, Likun Zan, Xu Guan, Xishan Wang   +13 more
doaj   +1 more source

Remote‐Controllable Immune‐Priming Spot Formation Via Nanocomplexed Hydrogel‐Assisted Histotripsy: Immunoasis

Advanced Materials, EarlyView.
A novel immunotherapeutic strategy combines injectable, adjuvant‐loaded hydrogels with externally controlled histotripsy to create immune‐priming sites within tumors. This approach generates millimeter‐sized immune‐activated lesions with flexible, patient‐tailored treatment scheduling, enabling precise immune activation through tumor ablation‐mediated ...
Sung Hoon Kim, Wonseok Choi, Yurim Kim, Hyeongmin Kim, Gu Won Jeong, Hyewon Park, Inchan Youn, Yoon Park, Sungmin Han, Young‐Min Kim   +9 more
wiley   +1 more source

Comparative Effectiveness of Immune Checkpoint Inhibitors vs Chemotherapy by Tumor Mutational Burden in Metastatic Castration-Resistant Prostate Cancer [PDF]

, 2022
Ryon P. Graf, Virginia Fisher, Janick Weberpals, Ole Gjoerup, Marni Brisson Tierno, Richard S.P. Huang, Nicolas Sayegh, Douglas I. Lin, Kira Raskina, Alexa B. Schrock, Eric A. Severson, James Haberberger, Jeffrey S. Ross, James Creeden, Mia Levy, Brian M. Alexander, Geoffrey R. Oxnard, Neeraj Agarwal   +17 more
openalex   +1 more source

Clonal neoantigens elicit T cell immunoreactivity and sensitivity to immune checkpoint blockade

Science, 2016
N. Mcgranahan, A. Furness, R. Rosenthal, S. Ramskov, R. Lyngaa, S. Saini, M. Jamal-Hanjani, G. Wilson, Nicolai J. Birkbak, C. Hiley, T. Watkins, S. Shafi, N. Murugaesu, R. Mitter, A. Akarca, J. Linares, T. Marafioti, J. Henry, E. V. Van Allen, Diana Miao, B. Schilling, D. Schadendorf, L. Garraway, V. Makarov, N. Rizvi, A. Snyder, M. Hellmann, T. Merghoub, J. Wolchok, S. Shukla, Catherine J. Wu, K. Peggs, T. Chan, S. Hadrup, S. Quezada, C. Swanton   +35 more
semanticscholar   +1 more source

Multiphysics‐Driven Assembly of Biomimetic Vesicles

Advanced Materials, EarlyView.
Artificial extracellular vesicles, derived from cell membranes, are manufactured using a multiphysics‐integrated microfluidic platform that combines nanoknife membrane rupture, herringbone chaotic mixing, and acoustothermal modulation. This standardizable workflow enables the predictable control of vesicle formation and therapeutic loading, while ...
Timofei Solodko, Ian Gimino, Aastha Chandiwala, Bayan Alkotoub, Ali Bashiri Dezfouli, Heiko Reith, Asjad Bakhtiar, Rojda Hicsanmaz, Johann Brenner, Christoph J. O. Kaiser, Elena Belli, Shilpi Pandey, Samuel D. Rabkin, Kornelius Nielsch, Gabriele Multhoff, Oliver Hayden, Morteza Hasanzadeh Kafshgari   +16 more
wiley   +1 more source

436 Immune checkpoint inhibitors in sinonasal squamous cell carcinoma [PDF]

Alan Wayne Jones, Shyam Kankotia, Zara Orozco, Robert Hsu, Jorge J. Nieva, Jacob Thomas   +5 more
openalex   +1 more source