Results 201 to 210 of about 406,045 (339)

GPCRs in CAR‐T Cell Immunotherapy: Expanding the Target Landscape and Enhancing Therapeutic Efficacy

Advanced Science, EarlyView.
Chimeric antigen receptor T cell therapy faces dual challenges of target scarcity and an immunosuppressive microenvironment in solid tumors. This review highlights how G protein‐coupled receptors can serve as both novel targets to expand the therapeutic scope and functional modules to enhance CAR‐T cell efficacy.
Zhuoqun Liu, Yuchen Xiao, Yamin Zhao, Lihe Dai, David J.H. Shih, Shikang Liang, Honglei Tian, Liu Liu, Feng Tian, Bing Liu, Lei Chang, Chao Zhang   +11 more
wiley   +1 more source

Cytoreductive nephrectomy in the era of immune-checkpoint inhibitors: back to the future? [PDF]

BJU Int
Flammia RS, Campi R, Bologna E, Bertolo R, Leonardo C, Calabrò F, Amparore D, Simone G, Young Academic Urologists (YAU) Renal Cancer Working Group.   +8 more
europepmc   +1 more source

A Case of Hepatocellular Carcinoma Developing Chronic Hepatitis E Following Steroid Use After Immune Checkpoint Inhibitor Therapy

Atsuko Soeda, Hanaka Ishii, Aya Ozone, Ryutarou Sawa, Takumi Wada, Yusuke Tsugane, Akari Himei, Isao Saura, Emi Nemoto, Yoshitaka Tange, Chiaki Enami, Daisuke Ochi, Yuichi Dai, Kazuto Ikezawa   +13 more
openalex   +2 more sources

120MO Inupadenant combined with chemotherapy in patients with non-squamous NSCLC progressing on or after immune checkpoint inhibitor therapy: Results from dose-finding part of the A2A-005 trial [PDF]

Kristof Cuppens, G. Lo Russo, Óscar Juan, E. Felip, Ma Carmen Areses Manrique, Alberto Chiappori, E. Govaerts, P.K. Cheema, L. Greillier, L. Toschi, Eric Schaefer, M. Clouseau, C. Martinoli, Hussein Shehade, Natalie Byrne, M. Fox, M. Rossetti, Olivier De Henau, S. Ross, S. Peters   +19 more
openalex   +1 more source

Supplementary Figures 1 through 5 from Vaccines Combined with Immune Checkpoint Antibodies Promote Cytotoxic T-cell Activity and Tumor Eradication

, 2023
Omar A. Ali, Sarah A. Lewin, Glenn Dranoff, David Mooney   +3 more
openalex   +1 more source

Immune Checkpoint Inhibitor [PDF]

, 2020
openaire   +1 more source

Depletion of the RNA‐Editing Enzyme ADAR1 Invigorates the Antitumor Immunity of NK Cells

Advanced Science, EarlyView.
ADAR1 is upregulated in NK cells from melanoma patients, impairing their function. Its loss enhances NK cell tumor infiltration and cytotoxicity in vitro and in vivo. Mechanistically, ADAR1 deficiency destabilizes CD38 mRNA to reduce its expression, thereby increasing NK cell mobility and killing, which nominates it as a therapeutic target for NK cell ...
Shuhan Chen, Di Lu, Rukang Liang, Weikeng Tan, Erming Zhao, Sihuang Wu, Xintong Li, Yulong Song, Miaojian Wan, Xiaoyuan Xie, Qi Zhang, Qiuli Liu   +11 more
wiley   +1 more source

Evaluating Hip Osteoarthritis as a Risk Factor for Immune Checkpoint Inhibitor-Induced Inflammatory Arthritis. [PDF]

J Rheumatol
Fitzpatrick R, Demehri S, Murray J, Brahmer JR, Ghotbi E, Barasa D, Bingham CO, Shah AA, Cappelli LC.   +8 more
europepmc   +1 more source

Data from A Dual PI3K/HDAC Inhibitor Induces Immunogenic Ferroptosis to Potentiate Cancer Immune Checkpoint Therapy

, 2023
Fushun Fan, Pei Liu, Rudi Bao, Jian Chen, Minhua Zhou, Zhenxian Mo, Yaru Ma, Haiqi Liu, Yiping Zhou, Xiong Cai, Changgeng Qian, Xinjian Liu   +11 more
openalex   +1 more source

Hierarchical Targeting of TREM2+ Myeloid Cells via Acid‐Triggered OMVs Reprogram Immunosuppression and Suppress Osteolysis in Bone‐Metastatic TNBC

Advanced Science, EarlyView.
This study developed a hierarchical targeting nanoplatform, siTREM2@ETP‐PEOz‐OMVs, against triple‐negative breast cancer (TNBC) bone metastasis. It precisely delivers therapeutic siTREM2 to monocytes/macrophages within the metastatic niche. This intervention dually regulates cell fate: reprogramming immunosuppressive macrophages and inhibiting ...
Fanglu Chen, Yucheng Xue, Xiao Ma, Liang Chen, Zhenxuan Shao, Hangxiang Sun, Haochen Mou, Fangqian Wang, Zilong Li, Yechao Shen, Zhaoming Ye, Xiaohua Yu, Shengdong Wang   +12 more
wiley   +1 more source