Results 221 to 230 of about 406,045 (339)

Advancements in the utilization of immune checkpoint inhibitors for the treatment of gynecological tumors. [PDF]

Front Immunol
Su Z, Zhang X, Xu J, Shen Y.
europepmc   +1 more source

Context‐Dependent Role of GDF15: GDF15+ Tumor‐Associated Macrophages Suppress OSCC Progression by Enhancing Phagocytosis

Advanced Science, EarlyView.
This study identifies GDF15+ TAMs as a cell subset mediating tumor regression after immunotherapy. Macrophage‐intrinsic GDF15 enhances phagocytosis and antigen cross‐presentation to CD8+ T cells through the NF‐κB signaling pathway, thereby inhibiting tumor progression.
Xinyu Zhou, Zhihang Zhou, Houyu Ju, Chaoyang Guo, Fangxing Zhu, Yiyi Zhang, Xu Chen, Tongchao Zhao, Laiping Zhong, Jingzhou Hu   +9 more
wiley   +1 more source

Combination Immunotherapy as a Promising Strategy to Overcome Immunotherapy Resistance: From Emergence to Next‐Generation Approaches

Advanced Science, EarlyView.
This review examines emerging combination immunotherapy strategies tailored to distinct tumor microenvironments and highlights next‐generation biomarkers that guide response prediction and treatment personalization. It integrates lessons from unsuccessful trials, addresses toxicity challenges, and outlines approaches for early biomarker discovery and ...
Asmita Pandey, Sudhir Kumar Rai, Li Ma, Lauren Higa, Vedbar Khadka, Hua Yang, Youping Deng   +6 more
wiley   +1 more source

A comprehensive review of mechanisms underlying resistance to immune checkpoint inhibitors. [PDF]

Front Immunol
Bertucci A, Taleb K, Billon E, Fernez T, Rochigneux P.   +4 more
europepmc   +1 more source

A Real-World Experience on the Efficacy of First-Line Treatment with Immune-Checkpoint Inhibitors in Non-Small-Cell Lung Cancer Patients with PD-L1 Expression ≥50%: The Role of KRAS Mutations

Lucia Motta, Samantha Epistolio, J. Pankovics, Francesca Molinari, Benjamin Pedrazzini, Alexandra Valera, Luca Giudici, Stefania Freguia, Miriam Patella, Martina Imbimbo, Giovanna Schiavone, Milo Frattini, Patrizia Froesch   +12 more
openalex   +1 more source

Reduced Maintenance DNA Methylation Thresholds Enable Sensitive Reporter Assays for UHRF1 and DNMT1 Inhibition

Advanced Science, EarlyView.
The authors engineer colorectal cancer cells with reduced redundancy of UHRF1 and DNMT1, key DNA methylation maintenance factors, lowering the maintenance threshold and sensitizing cells to inhibition. They develop reporter assays driven by endogenous tumor‐suppressor gene promoters with enhanced sensitivity and dynamic range to demethylating drugs ...
Cuicui Xia, Ying Cui, Jiongliang Wang, Wenjing Bai, Danyang Wang, Yao Chen, Huahui Guo, Liangyi Zong, Bing Qin, Xintong Cai, Jie Wang, Jing Huang, Scott B. Rothbart, Zufeng Guo, Stephen B. Baylin, Xiangqian Kong   +15 more
wiley   +1 more source

Association of Circulating T Cell and Tumor Microenvironment Profiles with Immune Checkpoint Blockade Outcomes in Sarcoma. [PDF]

Clin Cancer Res
Rosenbaum E, Ehrich F, Yosofvand M, Bradic M, Lee J, Adamow M, Movva S, Kelly CM, Avutu V, Banks LB, Chan JE, Chi P, Dickson MA, Gounder MM, Keohan ML, Maki RG, Reed DR, Fuentes P, Collins P, Desir R, Reiner A, Baranov O, Chernyshov K, Kotlov N, Subramanian A, Moding EJ, Qin LX, Wong P, Tap WD, Antonescu CR, Panageas KS, Shen R, D'Angelo SP.   +32 more
europepmc   +1 more source

Humanized and Charge‐Optimized CSPG4‐Specific CAR‐T Cells show Enhanced Efficacy against Head and Neck Squamous Cell Carcinoma

Advanced Science, EarlyView.
CSPG4 is identified as a high‐value, stemness‐associated target in HPV‐negative HNSCC. By implementing rational biophysical engineering, a humanized and charge‐optimized CAR is developed to overcome tonic signaling‐induced exhaustion. This strategy induces a profound transcriptomic shift toward a rejuvenated, stem‐like memory state, significantly ...
Xiang Xu, Shizhen Qiu, Zhitong Wang, Dan Li, Min Chen, Yinying Chu, Guangfei Li, Yi Fang, Changjiang Li, Fang Shi, Peijie He, Haitao Wu, Haopeng Wang, Jian Chen   +13 more
wiley   +1 more source

Clinical Analysis of Relapse Risk in Immune-Checkpoint-Inhibitor-Related Pneumonitis. [PDF]

J Clin Med
Maruyama K, Abe M, Kawasaki T, Horiuchi D, Sakuma N, Kitahara S, Ishii D, Ohno I, Takiguchi Y, Suzuki T.   +9 more
europepmc   +1 more source

Ecological and functional stratification of the stool microbiome predicts response to immune checkpoint inhibitors across cancer types

Vera Orletskaia, Evgenii I. Olekhnovich
openalex   +1 more source