Results 111 to 120 of about 1,252,407 (298)

Copine‐4 Paraneoplastic Autoimmune Encephalitis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT We characterize copine‐4 (CPNE4)‐IgG and report clinical associations. Among 844 samples with unclassified neural IgGs identified by mouse‐brain indirect immunofluorescence assay over 2 years, 5 samples (serum, 3; CSF, 2) from 3 patients produced a distinctive cerebrum‐restricted synaptic pattern.
Mimi S. Fang, Amy Ml Quek, Clement Yong, Amir Adeli, Gabrielle N. Conway, Connie E. Lesnick, Diana Anissian, Divyanshu Dubey, John R. Mills, Sean J. Pittock, Anastasia Zekeridou, Michael Gilligan, Andrew McKeon   +12 more
wiley   +1 more source

Extending Service Beyond Active Duty: Generalizability of Rheumatoid Arthritis Research Conducted Among US Veterans

Arthritis Care &Research, EarlyView.
Biomedical research involving US veterans continues to advance health care beyond the Veterans Health Administration. This is particularly true in rheumatoid arthritis (RA), where veteran‐centric research has uncovered novel insights into pathogenesis, risk factors, and disease manifestations, informing clinical care and research across both veteran ...
Austin M. Wheeler, Joshua F. Baker, Jennifer L. Barton, Maria I. Danila, Tate M. Johnson, Kamini Kuchinad, Kaleb Michaud, Amir A. Razmjou, J. Steuart Richards, Namrata Singh, Isaac D. Smith, Katherine D. Wysham, Grant W. Cannon, Bryant R. England, Amy Joseph, Deana Lazaro, Katherine P. Liao, Courtney Loecker, Andreas Reimold, Beth I. Wallace, Ted R. Mikuls   +20 more
wiley   +1 more source

The expression of immune checkpoints and the distribution of IC50 value.

The expression of immune checkpoints and the distribution of IC50 value.
Ruixia Guo (593499), Bowen Hu (3070770), Huanfei Ding (17952107)   +2 more
core   +1 more source

Figure S1 from Orchestration and Prognostic Significance of Immune Checkpoints in the Microenvironment of Primary and Metastatic Renal Cell Cancer

, 2015
Figure S1. Test of the specificity of anti-immune checkpoints : Immunohistochemical staining of immune checkpoints on sections from paraffin embedded cell pellets of untransfected and transfected cell lines used as negative and positive controls ...
Gordon J. Freeman (8747446), Diane Damotte (228307), Franck Pagès (10269071), Aurelie Cazes (14996417), Frederic Triebel (10338596), Virginie Verkarre (734368), Ivo Natario (14996414), Georgios Skliris (14996402), Etienne Becht (7374863), Laetitia Lacroix (14996411), Nicolas A. Giraldo (14996399), Arnaud Mejean (10711832), Nicolas Saint-Aubert (14996408), Stephane Oudard (14912130), Audrey Lupo (14914893), Catherine Sautès-Fridman (284683), Wolf H. Fridman (9467213), Yann Vano (14996405), Marco Alifano (375316), Marie-Caroline Dieu-Nosjean (228322)   +19 more
core   +1 more source

Bacteria‐Trained, MnO2‐Armored Dendritic Cells for Immunotherapy

Advanced Materials, EarlyView.
MnO2‐armored, bacteria‐trained dendritic cells undergo tumor‐responsive mechanical and immunological transformation. The nanocoating masks immune ligands and maintains a mechanically stiff, quiescent state during circulation, while the tumor microenvironment removes the armor and restores cellular deformability and immune accessibility.
Zhao Guo, Min Ge, Zesong Ruan, Tingwang Shi, Mahyar Mahmoudi, Soohwan An, Na Kong, Yunfeng Chen, Han Lin, Wei Tao   +9 more
wiley   +1 more source

Post-translational modifications of cancer immune checkpoints: mechanisms and therapeutic strategies

Molecular Cancer
Immunotherapies, particularly immune checkpoint inhibitors (ICIs), have revolutionized cancer clinical management, but low response rates and treatment resistance remain challenging.
Haiqing Jia, Lei Jiang, Xiaoyu Shen, Huinan Ye, Xinguang Li, Liwei Zhang, Yanyan Hu, Dandan Song, Hui Jia, Zhe Wang   +9 more
doaj   +1 more source

“Activation‐Resistance Elimination” Regulation by Lanthanide/Transition Metal Ion‐Coordinated Nanostructures Intensifies Cuproptosis and Tumor Immunotherapy

Advanced Materials, EarlyView.
The lanthanide/transition metal ion coordination nanoparticles, La‐Cu@Lap/IWR‐1, with optimized coordination, have been proven to achieve remarkable results in realizing comprehensive tumor cuproptosis through efficient cuproptosis activation and multidimensional resistance elimination, thereby synchronously realizing the synergistic antitumor effects ...
Junrong Wang, Mengqian Xu, Huaping Zhao, Yulin Xie, Guoqing Zhu, Haoze Li, Qianqian Sun, Yong Lei, Chunxia Li   +8 more
wiley   +1 more source

Proteostasis of immune checkpoint receptors

Biochemical Journal
Immunotherapy relies on the targeting of immune checkpoint receptors and their respective ligands by specific antibodies that bind to the cell surface proteins. The pace of this highly successful clinical advancement has outstripped our cell biological understanding of these receptors.
Pei Yee Tey, Sylvie Urbé, Michael J. Clague   +2 more
openaire   +3 more sources

Cardiotoxicity of immune checkpoint inhibitors

ESMO Open, 2017
Cardiac toxicity after conventional antineoplastic drugs (eg, anthracyclines) has historically been a relevant issue. In addition, targeted therapies and biological molecules can also induce cardiotoxicity. Immune checkpoint inhibitors are a novel class of anticancer drugs, distinct from targeted or tumour type-specific therapies.
VARRICCHI, GILDA, GALDIERO, MARIA ROSARIA, MARONE, GIANCARLO, CRISCUOLO, GJADA, TRIASSI, MARIA, BONADUCE, DOMENICO, MARONE, GIANNI, TOCCHETTI, CARLO GABRIELE   +7 more
openaire   +3 more sources

Profiling targetable immune checkpoints in osteosarcoma

OncoImmunology, 2018
Osteosarcomas are aggressive bone tumors for which therapeutic advances have not improved over several decades. Unlike most pediatric tumors, the osteosarcoma genome is remarkably unstable, characterized by numerous copy number alterations and ...
Troy A McEachron, Timothy J Triche, Laurie Sorenson, David M Parham, John D Carpten   +4 more
doaj   +1 more source