Results 121 to 130 of about 1,989,151 (330)
Pan-urologic cancer genomic subtypes that transcend tissue of origin [PDF]
, 2017 Urologic cancers include cancers of the bladder, kidney, prostate, and testes, with common molecular features spanning different types. Here, we show that 1954 urologic cancers can be classified into nine major genomic subtypes, on the basis of ...
Bossé, Dominick +9 more
core +2 more sources
Cancer immunology research, 2020 Complex branched N-glycans are identified as glyco-immune checkpoints that are used by colorectal cancer cells to evade immune recognition. The data highlight how inhibiting this glycosylation could be a strategy to improve antitumor responses.
M. C. Silva +21 more
semanticscholar +1 more source
Molecular Oncology, EarlyView.We developed and validated a DNA methylation–based biomarker panel to distinguish pleural mesothelioma from other pleural conditions. Using the IMPRESS technology, we translated this panel into a clinically applicable assay. The resulting two classifier models demonstrated excellent performance, achieving high AUC values and strong diagnostic accuracy.
Janah Vandenhoeck +12 more
wiley +1 more source
Role of mTOR signaling in tumor microenvironment. An overview [PDF]
, 2018 The mammalian target of rapamycin (mTOR) pathway regulates major processes by integrating a variety of exogenous cues, including diverse environmental inputs in the tumor microenvironment (TME).
Bazzichetto, Chiara +8 more
core +2 more sources
Endocrine Toxicity of Cancer Immunotherapy Targeting Immune Checkpoints.
Endocrine reviews, 2018 Immune checkpoints are small molecules expressed by immune cells that play critical roles in maintaining immune homeostasis. Targeting the immune checkpoints cytotoxic T-lymphocyte-associated protein 4 (CTLA-4) and programmed death 1 (PD-1) with ...
Lee-Shing Chang +5 more
semanticscholar +1 more source
Molecular Oncology, EarlyView.We developed a cost‐effective methylation‐specific droplet digital PCR multiplex assay containing tissue‐conserved and tumor‐specific methylation markers. The assay can detect circulating tumor DNA with high accuracy in patients with localized and metastatic colorectal cancer.
Luisa Matos do Canto +8 more
wiley +1 more source
Alterations of immune response of non-small lung cancer with azacytidine [PDF]
, 2013 Innovative therapies are needed for advanced Non-Small Cell Lung Cancer (NSCLC). We have undertaken a genomics based, hypothesis driving, approach to query an emerging potential that epigenetic therapy may sensitize to immune checkpoint therapy targeting
Baylin, Stephen B +27 more
core +1 more source
Cancer Immunotherapy by Blocking Immune Checkpoints on Innate Lymphocytes
Cancers, 2020 Simple Summary The emergence of immunotherapy for cancer treatment bears considerable clinical promise. The role of NK cells in tumor immunosurveillance and their potential for successful cancer immunotherapy strategies is currently established. Specific
Silvia Pesce +14 more
semanticscholar +1 more source
TREX1, a predator for treating MSI‐H tumors?
Molecular Oncology, EarlyView.Immunotherapy benefits many patients; yet, some with MSI‐H tumors remain unresponsive despite their high immunogenicity. Xu et al. reveal that TREX1 enables immune evasion by degrading cytosolic DNA and suppressing cGAS–STING–IFN‐I signaling. TREX1 loss restores DNA sensing, increases CD8+ T and NK cell infiltration, and boosts antitumor immunity ...
Elena Benidovskaya +2 more
wiley +1 more source
Metabolic checkpoints in immune cell reprogramming: rewiring immunometabolism for cancer therapy
Molecular CancerImmune cell metabolism plays a pivotal role in regulating cellular proliferation, differentiation, and functional responses, collectively shaping immune responses within the tumor microenvironment (TME). Recent advancements increasingly highlight diverse
Yingying Lv +16 more
doaj +1 more source